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Humanoriented perspective needed to better understand Parkinsons disease

first_imgReviewed by James Ives, M.Psych. (Editor)Sep 25 2018Analysis published in Drug Discovery Today reveals the gap between animal models of Parkinson’s disease (PD) and our understanding of the neurodegenerative processes underlying the disease, and calls for the implementation of modern, human biology-based technologies to better understand pathological processes and improve treatment outcome.While current approaches to drug discovery for PD have led to the development of tools for the motor symptoms that accompany neurodegeneration, they have fallen short of identifying preventative or curative therapies. The authors of “Parkinson’s disease research: adopting a more human perspective to accelerate advances” describe how this failure derives from the fact that animal disease models can never fully replicate the healthy or diseased human brain. Dr. Catherine Willett and Dr Lindsay Marshall advocate new approaches with greater focus on recent advances in systems biology computer science and engineering using information from human cells, tissues, and subjects.Dr. Willett, senior director of science and regulatory affairs at the Humane Society of the United States and Humane Society International, explained that “no animal model can fully recapitulate the complex multisystem pathology that underlies the clinical signs and symptoms of human PD. Rather, animal models typically reproduce specific pathological components but fail to account for the complete biology underlying the disease. Animal models therefore have limited capacity to reveal the true causes of, or identify real cures for, human Parkinson’s.”Rather than using limited research funds for creating more animal models or for modifying existing animal models, Dr Willett describes what is needed to better understand PD: “To definitively understand and treat Parkinson’s and other uniquely human neurodegenerative disorders, new approaches need to focus directly on human systems per se. Human-specific PD characteristics can be examined using human cell cultures, human stem-cell derived tissues, computer modeling, and new imaging modalities.”Related StoriesNovel device could enable early diagnosis and treatment development for Parkinson’s diseaseStudy reveals vitamin B12 as inhibitor of key enzyme in hereditary Parkinson’s diseaseGut infection can lead to a pathology resembling Parkinson’s diseaseEven though some animal models have provided valuable insight into PD’s pathophysiology, there has been no substantial progress in the development of new therapeutic treatments targeting the degenerative mechanisms underlying the disease. One of the major reasons for this is that by the time a patient displays PD symptoms, degeneration is already advanced, shifting the focus to symptomatic treatment. In addition, as increasingly demonstrated over the past decade, there are many difficulties in translating findings from animals to humans which lead to high failure rates and often catastrophic results, such as those seen with treatments for inflammation, hepatitis B and schizophrenia. With PD affecting 1-2% of the population over 65 years of age and a growing ageing population globally, the paper calls for investment in modern, human-based technology to address the poor translation of animal models from bench to clinic when devising solutions for PD. A concerted effort to approach PD from a systems biology, pathway-based, collaborative, human-oriented perspective could provide a foundation for innovative ways to analyze health and disease more generally. Source:http://www.hsi.org/last_img read more

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Home blood pressure measurements can be used to diagnose hypertension in US

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 29 2018Blood pressure readings of 130/80 millimeters of mercury (mm Hg) or higher taken at home can be used to diagnose hypertension in white, black and Hispanic U.S. adults, according to new research in the American Heart Association’s journal Hypertension.”Until now, recommendations for diagnosing high blood pressure with measurements done at home were primarily from Japanese and European studies,” said Wanpen Vongpatanasin, M.D., study author, professor of medicine and hypertension director at UT Southwestern Medical Center in Dallas. “We didn’t know if these recommendations actually applied to U.S. adults.”Researchers analyzed large multi-ethnic studies that compared home blood pressure to clinic measurements of primarily young and middle-aged adults in Dallas, Texas and Durham, North Carolina. In 420 participants in the North Carolina clinic, high blood pressure readings (130/80) were confirmed with similar readings at home. In 3,132 participants in the Dallas study, researchers determined risks of stroke, heart attack and death associated with a clinic systolic blood pressure reading of 130 mm Hg. During the 11-year follow up, researchers also determined that people with high blood pressure levels measured at home had the same heart disease risk as people with similar levels measured by medical professionals.Related StoriesBlood pressure self-monitoring can help patients with hypertension to stick with exercise programMathematical model helps quantify metastatic cell behaviorDon’t ignore diastolic blood pressure values, say researchersVongpatanasin added that the findings correlate with the American Heart Association/American College of Cardiology 2017 blood pressure guideline.”It’s important to measure blood pressure at home because clinic readings might not reflect a person’s true blood pressure. Some people have higher readings in the clinic because of the ‘white coat’ phenomenon, while studies have shown that others – especially, blacks – have lower blood pressure readings in the clinic than at home,” she said.This study included adults aged 30 to 65 years old from two U.S. cities, so the findings might not apply to younger or older people or adults in different geographical areas, she said.With the definition of high blood pressure set at 130/80 mm Hg, nearly half (46 percent) of U.S. adults have high blood pressure. Researchers have found that at least 30 percent to 45 percent of U.S. adults with hypertension monitor their blood pressure at home.The American Heart Association recommends consumers follow the proper technique when measuring blood pressure: be still and rest quietly for at least 5 minutes before measurements; avoid caffeine or cigarettes in the half hour before your reading; keep both feet flat on the floor; and avoid talking during the test. At least two readings should be taken one minute apart in the morning before taking medications and in the evening before eating. Ideally, blood pressure readings should be taken during one week beginning a few weeks after a change in the treatment regimen and during the week before a doctor’s visit. Source:https://newsroom.heart.org/news/home-monitoring-confirms-clinic-diagnosis-of-high-blood-pressure?preview=3656last_img read more

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Antiinflammatory biologic therapy may prevent heart disease in patients with skin condition

first_img Source:https://www.escardio.org/ Reviewed by James Ives, M.Psych. (Editor)Feb 5 2019Anti-inflammatory biologic drugs used to treat severe psoriasis have the potential to prevent heart disease in patients with the skin condition, according to research published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC). During one year of treatment, biologic therapy improved coronary artery plaque similar to the effect of a low-dose statin.”Psoriasis severity is related to the burden of coronary disease – our findings suggest treating the psoriasis may potentially benefit coronary heart disease,” said study author Dr Nehal Mehta, Chief of Inflammation and Cardiometabolic Diseases at the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, US.Psoriasis causes scaly skin patches, often on the elbows, knees, scalp, and lower back. Patients with the skin condition have an elevated risk of heart disease – young patients with severe psoriasis are at twice the risk of having a first heart attack at 40-50 years of age.Psoriasis patients often have inflammation throughout the body and may be treated with anti-inflammatory biologic therapy when their skin condition is severe and topical treatments or phototherapy have failed. This study investigated whether treating severe psoriasis with a biologic could improve the health of the coronary arteries.The study found that patients with severe psoriasis who took biologic therapy for one year had an 8% reduction in total and non-calcified coronary plaque burden, a frequent cause of heart attacks (see figure) – similar to the effect of a low dose statin. The make-up of coronary plaques also improved in those taking biologics, making them less risky. Coronary plaque burden increased by 2% in patients who did not take a biologic.Dr Mehta said: “We found that these anti-inflammatory drugs commonly used to treat severe psoriasis also improve plaque in the coronary artery making them more stable and less likely to cause a heart attack. This occurred in the absence of changes in traditional cardiovascular risk factors including blood pressure and blood lipids.”Related StoriesStroke should be treated 15 minutes earlier to save lives, study suggestsCutting around 300 calories a day protects the heart even in svelte adultsCancer incidence among children and young adults with congenital heart diseaseDuring the one-year study, systemic inflammation assessed by blood markers reduced only in the group taking biologic therapy. Dr Mehta said it is too early to say whether biologics exert their effects on coronary plaques directly or by reducing systemic inflammation.He said: “This preliminary study provides the first evidence that biologic therapy is associated with coronary plaque reduction and stabilization, and provides strong rationale for conduct of a randomized trial testing the impact of biologic therapy on the progression of coronary disease in patients with psoriasis.”Dr Mehta noted that some patients with severe psoriasis opt not to take a biologic medicine because they suppress the immune system and may increase the chance of infection. In addition, they must be injected.Previous research has shown that in heart attack patients, anti-inflammatory biologic therapy reduces the risk of another cardiovascular event.2 “With the results of that study and our current one, my message to patients with psoriasis is to take untreated inflammation seriously,” said Dr Mehta. “When someone has severe psoriasis, they are at higher risk of heart attack and treating the psoriasis may reduce that risk.”The observational study included 121 patients with severe psoriasis who qualified for biologic treatment. Of those, 89 took biological therapy (one of three types) and 32 used topical treatment. All patients underwent imaging of their coronary arteries with computed tomography angiography at baseline and one year later to assess the amount and characteristics of plaques such as the necrotic core which causes plaque rupture.last_img read more

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Early genome catastrophes can lead to development of lung cancer in nonsmokers

first_imgThe research team plans to further focus on the molecular mechanisms that stimulate complex rearrangements in the body, through screening the genomic structures of fusion genes in other cancer types.Source:The Korea Advanced Institute of Science and Technology (KAIST)Journal reference:Kim, Y.T. et al. (2019) Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma. Cell. doi.org/10.1016/j.cell.2019.05.013. We hope this work will help us get one step closer to precision medicine for lung cancer patients.” Reviewed by Alina Shrourou, B.Sc. (Editor)May 31 2019Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related lung cancers develop.Researchers at KAIST, Seoul National University and their collaborators confirmed that gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and on average about three decades before cancer is diagnosed. The study showed that these mutant lung cells, harboring oncogenic seeds, remain dormant for several decades until a number of further mutations accumulate sufficiently for progression into cancer. This is the first study to reveal the landscape of genome structural variations in lung adenocarcinoma.Lung cancer is the leading cause of cancer-related deaths worldwide, and lung adenocarcinoma is its most common type. Most lung adenocarcinomas are associated with chronic smoking, but about a fourth develop in non-smokers. Precisely what happens in non-smokers for this cancer to develop is not clearly understood.Researchers analyzed the genomes of 138 lung adenocarcinoma patients, including smokers and non-smokers, with whole-genome sequencing technologies. They explored DNA damage that induced neoplastic transformation.Lung adenocarcinomas that originated from chronic smoking, referred to as signature 4-high (S4-high) cancers in the study, showed several distinguishing features compared to smoking-unrelated cancers (S4-low).People in the S4-high group were largely older, men and had more frequent mutations in a cancer-related gene called KRAS. Cancer genomes in the S4-high group were hypermutated with simple mutational classes, such as the substitution, insertion, or deletion of a single base, the building block of DNA.But the story was very different in the S4-low group. Generally, mutational profiles in this group were much more silent than the S4-high group. However, all cancer-related gene fusions, which are abnormally activated from the merging of two originally separate genes, were exclusively observed in the S4-low group.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSpecial blood test may predict relapse risk for breast cancer patientsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe patterns of genomic structural changes underlying gene fusions suggest that about three in four cases of gene fusions emerged from a single cellular crisis causing massive genomic fragmentation and subsequent imprecise repair in normal lung epithelium.Most strikingly, these major genomic rearrangements, which led to the development of lung adenocarcinoma, are very likely to be acquired decades before cancer diagnosis. The researchers used genomic archaeology techniques to trace the timing of when the catastrophes took place.Researchers started this study seven years ago when they discovered the expression of the KIF5B-RET gene fusion in lung adenocarcinoma for the first time. Professor Young-Seok Ju, co-lead author from the Graduate School of Medical Science and Engineering at KAIST says, “It is remarkable that oncogenesis can begin by a massive shattering of chromosomes early in life. Our study immediately raises a new question: What induces the mutational catastrophe in our normal lung epithelium.”Professor Young Tae Kim, co-lead author from Seoul National University says:last_img read more

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New class of cancerkilling agents shows promise in destroying cancer stem cells

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 9 2019Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone. Taylor and Dr. L.M. Viranga Tillekeratne, a professor in the Department of Medicinal and Biological Chemistry in the UToledo College of Pharmacy and Pharmaceutical Sciences, reported their findings in a paper recently published in the journal Scientific Reports.Cancer stem cells are an intriguing target for researchers because of their potential to re-seed tumors.When doctors remove a tumor surgically or target it with chemotherapy drugs or radiation therapy, the cancer may appear to be gone. However, evidence suggests that a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations.Those cancer stem cells, Taylor said, are similar to dandelions in a well-manicured lawn.”You could chop the plant off, but it will drop a seed. You know the seeds are there, but they’re hiding,” he said. “You pull one weed out and another comes up right after it. Cancers can be like this as well.”Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe small molecule they have isolated appears to lock on to those stem cells and kill them by blocking their absorption of an amino acid called cystine.UToledo was awarded a patent for the discovery late last year.For Tillekeratne and Taylor, uncovering a new class of therapeutic molecules could prove to be an even larger contribution to cancer research than the project they initially envisioned.”At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research. This also shows the beauty of collaboration. I wouldn’t have been able to do this on my own, and [Taylor] wouldn’t have been able to do it on his own.”Tillekeratne has received a three-year, $449,000 grant from the National Institutes of Health National Cancer Institute to continue testing the effectiveness of the newly identified therapy.Because the molecules so selectively target cancer stem cells, it’s possible they could ultimately be paired with other chemotherapy drugs to deliver a more comprehensive treatment.However, the researchers have found their agents show stand-alone promise in treating sarcomas and a subtype of breast cancer known as claudin-low breast cancer, which represents up to 14 percent of all breast cancers and can be particularly difficult to treat. Source:University of ToledoJournal reference:Taylor, W.R. et al. (2019) Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific Reports. doi.org/10.1038/s41598-019-42251-5. Not all cancer cells are the same, even in the same tumor. There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”Dr. William Taylor, professor in the Department of Biological Sciences, UToledo College of Natural Sciences and Mathematicslast_img read more

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Special cameras limit radiation while delivering images vital for patient health

first_imgReports show that in Germany in 2013, although CT scans only represented 7 % of all X-rays performed, they conveyed 60 % of the radiation that patients received. We built several prototype cameras. As an alternative to CT, they enable 3D X-ray imagines in very few exposures, meaning less radiation for the patient.”Marta Fajardo, project coordinator and assistant professor at the Instituto Superior Técnico in Lisbon, Portugal New perspective on 3D imagingCT scans make images by taking thousands of flat, two-dimensional photos in order to reconstruct a 3D image. The problem is that each photo injects ionizing radiation into the patient. As photos multiply, radiation levels rise.To counter this, VOXEL’s breakthrough idea was to adapt a technique called plenoptic imaging to X-ray radiation. Plenoptic cameras capture information about the direction that light rays, including X-rays, are traveling in space, as opposed to a normal camera that captures only light intensity.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSubclinical cardiovascular disease linked to higher risk of falling in older adultsNew protein target for deadly ovarian cancerBecause researchers can use the information about light direction captured by plenoptic cameras to reconstruct 3D images, there is no need to take thousands of 2D photos. Images of important structures like blood vessels can be made from a single exposure, lowering the average radiation dose significantly.A major part of the work was using the right algorithms to manipulate the captured information. ‘First, we demonstrated that plenoptic imagining is mathematically equivalent to a limited-angle tomography problem,’ Fajardo says. ‘Then we could simply reformat plenoptic imaging as tomography data and apply image reconstruction algorithms to obtain much better images.’But the biggest challenge remained engineering the cameras. ‘The higher the photon energy, the harder it is to manufacture the optics for a plenoptic camera,’ she says. ‘You need X-rays of different energies for different tasks.’ The solution was to develop one camera prototype that used lower-energy X-rays for tiny structures like cells and another that used higher-energy X-rays for larger objects, such as small animals or human organs.Less radiation, healthier patientsWhile Fajardo is encouraged by the project’s results, work remains to be done. ‘The low-energy X-ray camera belongs to a niche market,’ she explains. ‘But the high-energy X-ray prototype has huge medical potential, although it still requires some development.’Results from the project, which was awarded a Future Emerging Technologies grant, will soon be submitted for publication in the international science journal Nature Photonics. Source:European Commission Reviewed by James Ives, M.Psych. (Editor)Jul 15 2019CT scans have revolutionized the fight against human illness by creating three-dimensional images of the body’s inner workings. Such scans, however, can deliver high doses of radiation. Now EU-funded researchers have built special cameras that limit radiation while delivering images vital for patient health.Doctors have used computed tomography scans, or CT scans, to greatly improve the diagnosis and treatment of illnesses such as cancer and cardiovascular disease. But a major problem limits their use: they deliver high doses of radiation that can harm patients nearly as much as their ailment.Enter the EU-funded VOXEL project which set out to develop an innovative way to create three-dimensional imaging. The result is special cameras that can deliver 3D images but without the high doses of radiation.last_img read more

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Largest study finds CTE in 6 of athletes and nonathletes

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 23 2019Nearly 6% of athletes and non-athletes were found to have the neurodegenerative disorder chronic traumatic encephalopathy (CTE) in the largest, and broadest, study conducted of the disease to date. The findings were published June 14 in the international journal Brain Pathology. Generally our findings point to CTE being more common in athletes and more common in football players, but this study is a bit more balanced and accurately reflects the general population compared to previous studies.”Lead author Kevin Bieniek, Ph.D., of UT Health San Antonio Dr. Bieniek led the research while at the Mayo Clinic before moving to Texas. He now directs the brain bank at the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, which is part of UT Health San Antonio.Unbiased screenCTE, linked with repetitive blows to the head, has been found in 80-99% of autopsied brains of pro football players. “Nobody has really looked at it from kind of an epidemiological perspective,” Dr. Bieniek said. “We compared people who played a sport with those who didn’t play. We studied both young and old people, and amateur players versus college and professional players. And we studied both men and women, which had not been done previously. What we aimed to do was an unbiased screen for CTE from all sorts of different cases.”Biographical information utilizedThe team scanned obituaries and high school yearbooks of 2,566 individuals whose brain autopsies are a part of the Mayo Clinic Tissue Registry. The study focused on a variety of contact sports: baseball, basketball, boxing, football, hockey, lacrosse, soccer and wrestling. Non-contact sports, such as golf and tennis, were excluded.This analysis identified 300 former athletes and 450 non-athletes. “We screened the brains of all of these cases for evidence of CTE in a blinded fashion, intentionally not knowing which brain tissue was related to which case,” Dr. Bieniek said.FindingsA small number of cases, 42, had CTE pathology (5.6% of the total). CTE was found in 27 athletes and 15 non-athletes, and in 41 men and one woman. American football had the highest frequency of CTE (15%) of the contact sports studied, with participation beyond high school resulting in the highest risk of developing CTE.Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingStudy offers clues about how to prevent brain inflammation in Alzheimer’sIT Faces the Digital Pathology Data Tsunami”The 42 cases, or 6%, is more of a grounded, realistic number,” Dr. Bieniek said. “That might not seem like a lot, but when you consider there are millions of youth, high school and collegiate athletes in the United States alone who play organized sports, it has the potential of being a significant public health issue. There are many ongoing questions regarding CTE pathology, however, and we don’t want to discourage sources of healthy physical and cardiovascular activity like these sports. Rather, we emphasize safe strategies to reduce the possibility of head injuries and properly treat them when they are sustained.”Non-athletes’ casesThe identification of 15 CTE cases in non-athletes raises interesting questions, Dr. Bieniek said. “Did these people have trauma from another source?” he asked. “Were they actually athletes and we were unable to detect it from biographical information? Is there another disease with similar features?”Cases with CTE tended to be a bit older than the cases without it, and many CTE cases also showed evidence of Alzheimer’s disease. “At the Glenn Biggs Institute, we study the concept of multiple neurodegenerative disorders happening within the brain of a person who has dementia,” Dr. Bieniek said.The crucial role of donors”This is an important national study led by our brain bank director, Dr. Bieniek,” said Sudha Seshadri, M.D., professor of neurology at UT Health San Antonio and director of the Glenn Biggs Institute. “We have a great team of scientists at the Biggs Institute, and the brain bank is key to the research aims of these investigators. We are so grateful for the many patients and normal older persons who have signed on to be brain donors after their death. The program runs 24/7/365, is free to the family, and gives the family the peace and knowledge of a definitive diagnosis for their loved one’s condition.”Several studies related to traumatic brain injuries and CTE by Dr. Bieniek and his colleagues are currently ongoing at UT Health San Antonio, including how certain genetic variants might protect or put a person at higher risk for developing CTE. Source:University of Texas Health Science Center at San AntonioJournal reference:Bieniek, K.F. et al. (2019) Association between contact sports participation and chronic traumatic encephalopathy: a retrospective cohort study. Brain Pathology. doi.org/10.1111/bpa.12757.last_img read more

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A brief history of immersion centuries before VR

first_img Engraving depicting one of Robertson’s phantasmagorical shows and the effects they had on audiences. Credit: Memories by Etienne Gaspard Robertson Immersive experiences are fashionable at the moment, as virtual reality finally emerges into the mainstream with headsets now commercially available. But immersion is a technique much older than technology. It is the key to storytelling, in literature, film, videogames, even in the spoken stories told by our ancestors around the campfire. We are taken in by the experience: we become so involved with a character that we share their emotions, or build expectations about their progress in the story – and react when these expectations are either fulfilled or thwarted. Provided by The Conversation Credit: milliganpuss, CC BY You can imagine the multi-sensory aspects of this experience: the design and shape of the space would have been critical to its impact on the audience, with light flooding in from the east. With dust and smoke in the interior, and the sound of a priest’s sermon and choir reverberating around the vaulted ceilings, even by today’s standards it would be pretty immersive.Smoke and mirrorsIn the late 18th century, the quirkily named phantasmagoria used – quite literally – smoke and mirrors along with magic lanterns, a form of early image projector, invisible screens and sound effects to create a theatrical performance. This article was originally published on The Conversation. Read the original article. Citation: A brief history of immersion, centuries before VR (2018, May 16) retrieved 18 July 2019 from https://phys.org/news/2018-05-history-immersion-centuries-vr.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Recovered written accounts of the phantasmagoria are very interesting, as they link the rise in the use of magic lantern projections with the history of cinema. Via these immersive experiences, we get to the development of contemporary virtual reality devices.The origins of phantasmagoria are associated with the work of German Johann Georg Schropfer who used magic lantern projections as part of monastic rituals – another form of immersive religious experience.Participants would often fast for 24 hours prior to a performance and were greeted ceremoniously with drugged punch or salad. Skulls, candles and other monastic paraphernalia were used to set the scene. Accounts indicate that in these original performances three ghosts would be summoned, serving the monastic search for a deeper truth through contact with the spirit world. To be fully immersive, sources of haptic stimulation in VR apps need to be shown, researchers find Look at immersion from a historical perspective and we see the rituals and social practices that gave rise to immersive experiences, and the relevance of the past to the hyped products of today.In the middle ages, the use of stained glass in churches was designed to create an immersive sense of otherworldliness by bathing the church’s interior with coloured light. It was designed to provide churchgoers with a sense of direct contact with the divine, through visual stories aimed at a largely illiterate population.Stained glass was an important form of visual storytelling. It was one of the ways that religious institutions could exert their hold on believers through the sanctity of messages delivered through colour and light, for which believers had to crane their necks up towards the sky to face the high windows.A great example of this is the recently restored Great East Window at York Minster, a very large expanse of painted glass created in the early 1400s. The sheer scale of this window is extraordinary. It is the largest expanse of glass in the minster and one of the biggest in Europe. All designed and created by one artist, John Thornton. Its subject is no less than the beginning and the end of the world representing in its huge number of panes scenes from Genesis and from the Day of Judgement. As such, it can be easily interpreted as a form of immersive storytelling for audiences of the late middle ages. Inflicting terrorThis soon became popular entertainment, and the showman Paul Philidor produced elaborate shows for audiences in Vienna. Another was the Belgian Etienne-Gaspard Robertson in the first few years of the 19th century in Paris. He would use three moving magic lanterns behind a transparent screen, accompanied by elaborate costumes and decorations and augmented with horrifying sounds, to inflict terror upon his audience. With the growing Victorian interest in all things gothic, phantasmagoria performances spread to England where they were delivered alongside seances to deceive, terrify and manipulate their audiences. Some of the mechanics of today’s immersive experiences can be found in these early examples. The use of a projection system is common to phantasmagoria and to contemporary cinema. Head-mounted displays seen in modern VR systems can be first seen in the stereoscopic imagery of the View Master, which dates back to the 1930s and is still available in children’s toy shops today. From the 1950s, different cinematic techniques were introduced, including 3-D cinema using stereoscopic glasses, an approach that still captivates audiences to this day – the 3-D film Avatar is among the most financially successful movies of all time. I remember one of my first immersive experiences was watching How the West Was Won in the 1960s on a Cinerama screen – where a film is projected onto a giant, curved screen that provides an immersive experience via the wrap-around effect of the huge screen on the viewers’ field of view.So the current obsession with immersive virtual and augmented reality experiences will continue – we love our illusions and the stories that go with them. But we should not forget that to be swept away and out of the present by an immersive story is a timeless human desire, that’s origins go back as far as we do. Great East Window, York Minster, which depicts scenes from the beginning and the end of the world. 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Solar Impulse Efficient Solution label for profitable startups to boost clean energy

first_imgInvestors respond better to the profit potential of green innovations such as solar-powered planes rather than their eco-credentials, according to Dr Bertrand Piccard, founder of Solar Impulse. Credit: Milko Vuille, licensed under CC BY-SA 4.0 New energy innovation report highlights central role of emerging economies Provided by Horizon: The EU Research & Innovation Magazine It was one of a number of initiatives launched at the Mission Innovation clean energy conference in Malmö, Sweden, on 23 May.Clean energy innovations are often high risk, yield low returns and take a long time to reach maturity. The idea of the label is that showing the financial impact of environmental solutions will help sell the concept of clean and renewable energy to governments and potential financial backers. It’s led by Dr Bertrand Piccard, the first person to fly around the world in a solar-powered aircraft.’When we consider climate change and consumption, it’s not only our comfort, our growth, our lifestyle that is the reason for that,’ said Dr Piccard. ‘It’s the fact that the technologies that we use are wasting half of the energy that is produced. Half of the pollution is only due to the losses, to the waste and the inefficiencies of the systems that are in use today.’He told the conference that he had already used arguments around profitability and job creation to convince right-wing politicians in Switzerland, who are generally against environmental initiatives.By the end of 2018, Dr Piccard aims to have selected 1,000 recipients of the label, and the EU is helping to reach the target by identifying the most promising EU-funded projects.Carlos Moedas, EU Commissioner for Research, Science and Innovation, who launched the label with Dr Piccard, said that it would change the conversation around clean energy by focusing on solutions.’The efficient solutions label clearly demonstrates the economic opportunities that innovative clean technologies bring,’ he said. ‘Its rigorous and strict criteria will help raise the profile of new breakthrough solutions and make them attractive for investors.’In 2019, Dr Piccard will travel around the world to promote the solutions to governments and businesses, and they will also be presented at the UN’s 24th climate change conference COP24 in December 2018. The aim is to encourage the adoption of more ambitious environmental targets and energy policies by highlighting the financial advantages of doing so.Two-thirdsEnergy consumption and production account for two-thirds of greenhouse gas emissions, so sustainable energy innovation is vital if the world is to achieve its climate goals. Explore further The pioneering solar flight foundation Solar Impulse has launched an ‘Efficient Solution’ label for clean energy start-ups and innovations that can demonstrate their profitability, in a bid to boost investment in the sector. That’s one of the reasons that the Mission Innovation project was launched in 2015 at the Paris climate change conference, where countries agreed to limit global warming to two degrees above pre-industrial levels. It aims to double public investment for early-stage clean energy entrepreneurs by 2021 in a bid to dramatically speed up innovation in this sector, and is supported by 24 members, including the EU.’Citizens and innovators can help us to accelerate the clean energy revolution,’ said Commissioner Moedas.Ahead of the Malmö conference, the World Economic Forum (WEF) launched a white paperthat identified the main problems faced by clean energy entrepreneurs, including a so-called financial valley of death – meaning that there is little long-term risk capital available in the sustainable energy sector.According to the WEF, governments currently supply more than two-thirds of global investment into research development and demonstration (RD&D) for clean energy projects, while most private RD&D is focused on oil and gas rather than renewable technology.The paper set out six bold ideas for improvement – including creating institutions for energy innovation, establishing an independent international fund to finance energy projects that combines public and private donations, and developing instruments for public-private co-investment. It highlighted the need for alliances between organisations and companies that promote innovation, and praised the Mission Innovation programme as a best-practice example.Through the Mission Innovation initiative, India has also proposed an international incubator to test clean energy technologies in local markets, and Sweden has launched a competition to promote disruptive innovations funded by public-private partnerships.However, part of the problem is a lack of visibility, as clean energy entrepreneurs don’t always have access to the platforms where potential investors are active.ChampionsIn an effort to address this, Mission Innovation is setting up a Mission Champions scheme to promote excellent clean-energy researchers and innovators and raise their profile on a global scale.The champions will be flown to the next Mission Innovation conference where they have the opportunity to network with ministers and business leaders, and they will be encouraged to engage in cross-border idea exchanges with other champions. The idea is that through the scheme, the champions’ visibility will be enhanced, which could lead to potential investment opportunities.To date, the Mission Innovation initiative has set out seven so-called Innovation Challenges that push member countries towards ambitious goals in a variety of clean energy sectors. The EU is co-leading challenges on converting sunlight into storable solar fuels and affordable heating and cooling of buildings. A new eighth challenge on hydrogen energy was launched this week and will also be led by the EU.So far, research in this area has boosted the production of aviation biojet fuels under the ITAKA project and have led to the development of new approaches to make building heating and cooling systems more sustainable and efficient under the Celsius City project. ITAKA in particular achieved greenhouse gas savings of more than 70%, and improved local air quality by 30%. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Solar Impulse ‘Efficient Solution’ label for profitable start-ups to boost clean energy investment (2018, May 28) retrieved 18 July 2019 from https://phys.org/news/2018-05-solar-impulse-efficient-solution-profitable.htmllast_img read more

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France sees red after Spanish rose wine found in domestic bottles

first_img © 2018 AFP Summer is the ideal time for breaking out a bottle of rose, but fans of French wine might think twice after millions of bottles were found to contain less costly Spanish tipple instead. Explore further ‘Question of price’Tensions have long simmered between winegrowers on either side of the Pyrenees, with French producers often accusing their Spanish rivals of unfair competition.In recent years French protests have blocked Spanish trucks from bringing their wine into the country, with demonstrators emptying their loads onto highways.Production surpluses in Spain have pushed down prices there, making the country’s wines a better deal for consumers—and a tempting substitute for some French distributors.”It’s a question of price,” Jerome Despey, a winegrower in the southern Herault region and member of the FNSEA agricultural union, told AFP.The two countries’ agriculture ministers met in Paris last summer to try to end the conflict, leading to a series of measures aimed at limiting price volatility, Despey said.Price increases across Europe following weather-related grape harvest shortfalls last year have also helped ease tensions.”We need to keep up the pressure with these inspections so this kind of thing can’t happen again,” Despey said, urging the government to impose stricter labelling rules.Delphine Geny-Stephann, France’s junior economy minister, said she had asked the fraud agency “to continue carrying out regular inspections in the sector.” French winemakers emptying wine from a Spanish truck during a protest Le Boulon, ten kilometres forms the French-Spanish border, in April 2016 French farmers block refineries over palm oil importscenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: France sees red after Spanish rose wine found in domestic bottles (2018, July 9) retrieved 18 July 2019 from https://phys.org/news/2018-07-france-red-spanish-rose-wine.html French investigators found that millions of bottles of rose actually contained Spanish wine France’s consumer fraud agency confirmed Monday that 70,000 hectolitres—the equivalent of 10 million bottles—of Spanish rose were falsely labelled as French vintages by hundreds of producers in 2016 and 2017.According to French daily Le Parisien, which first reported the findings, Spanish rose sold in bulk at the time for just 34 euro cents ($0.40) a litre compared with 75 to 90 cents for French rose.”We were alerted to the ‘Frenchification’ of Spanish wine at the end of 2015,” the consumer agency’s Alexandre Chevallier told the paper.”So we launched an inquiry at all levels, from producers to importers to restaurants and distributors,” he said.Twenty-two percent of the businesses subjected to controls in 2016 and 15 percent in 2017—a total of 743 establishments—were cited for trying to present the foreign wine as French, he explained. Some blatantly passed it off as French, as was the case for bottles showing drawings of French-sounding but fictitious castles, or wines sold by the glass in some restaurants.Others were more subtle, putting “Produced in France” on the front label but “European Community wine” on the back, or embellishing bottles with national symbols like the heraldic lily or a ribbon in the blue, white and red of the French flag.Misleading wine drinkers is no small matter in France: producers could face fraud lawsuits that carry penalties of up to two years in prison and 300,000 euros in fines.last_img read more

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Dyson switches HQ from Britain to Singapore company

first_imgBritish electric appliance pioneer Dyson will switch headquarters to Singapore this year due to booming Asian demand but not because of Brexit, the company said Tuesday. © 2019 AFP The group, founded and owned by serial entrepreneur and vocal Brexit supporter James Dyson, last year announced it would produce electric cars in Singapore.The firm stressed that Brexit was not a factor behind the decision to ditch its corporate base in Malmesbury in Wiltshire, western England, in favour of Singapore.Dyson, famed for its cordless vacuum cleaners, hand dryers and fans, now has its sights set on electric vehicles—particularly in Asia.”An increasing majority of Dyson’s customers and all of our manufacturing operations are now in Asia; this shift has been occurring for some time and will quicken as Dyson brings its electrical vehicle to market,” it said in an earnings statement.”As a result, an increasing proportion of Dyson’s executive team is going to be based in Singapore; positioning them to make the right decisions for Dyson in a quick and efficient way.”This does not change any of our investment and recruitment plans; however we are now at a point where Dyson’s corporate head office will relocate there to reflect the increasing importance of Asia to Dyson’s business.”A prototype Dyson electric vehicle is in the works for 2020, followed by a product launch in 2021.’Not related to Brexit’The Singapore move “is not related to Brexit”, chief executive Jim Rowan told reporters on a conference call, noting there was only a “negligible” tax benefit.”We don’t see any issues regarding Brexit,” he said, adding that Dyson’s manufacturing capacity, as well as the majority of its supply base, is in south east Asia.”We are a global technology company,” Rowan insisted, adding that it would continue to invest in home market Britain.Dyson had already announced last October that it had picked Singapore for its first electric car plant, sparking criticism from some quarters that its Brexit-backing billionaire founder had not invested more in the UK.But the group also said in March that it would open a second research and development centre in a former Royal Air Force airfield in Hullavington, southwest England.Meanwhile on Tuesday, Dyson said that 2018 underlying profit—as measured by earnings before interest, taxes, depreciation and amortisation (EBITDA)—surged one third to £1.1 billion (1.2 billion euros, $1.4 billion).Turnover, or sales, rose by 28 percent to stand at £4.4 billion on growing global appetite for cutting-edge technology.”Globally, enthusiastic owners are demanding high-performance products so we are deepening out operations and technology investments to meet their needs,” added Rowan.James Dyson, who owns 100 percent of the company he founded in the 1970s, has revolutionised household appliances with his bagless vacuum cleaners, bladeless fans and air purifiers. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Citation: Dyson switches HQ from Britain to Singapore: company (2019, January 22) retrieved 17 July 2019 from https://phys.org/news/2019-01-dyson-hq-britain-singapore-company.html Leaving Britain, but not because of Brexit Dyson shifts up a gear with electric car hublast_img read more

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Virudhunagar is the best aspirational district

first_imgTamil Nadu policy COMMENT December 27, 2018 Virudhunagar district in Tamil Nadu, followed by Nuapada in Odisha and Siddharthnagar in Uttar Pradesh, have emerged as best performers among 112 backward districts in the country, in a household survey carried out for government policy think tank, Niti Aayog.At the bottom of the table are Pakur (Jharkhand), Hailakandi (Assam) and Chatra (Jharkhand).The rankings has reflected improvements that these districts achieved on 49 parameters relating to education, health, agriculture, basic infrastructure, financial inclusion and skill development in two surveys involving 1,00,000 households conducted in June and October this year.In January this year, Niti Aayog has declared these districts, which are backward in many aspects, as ‘aspirational districts’ to enable focussed development. Besides, ranking them on the basis of their subsequent performance also helps them to compete with one another, Niti Aayog CEO Amitabh Kant told reporters on Thursday. —————————————————-    Most improved districtsLeast improved districts1.Virudhunagar (Tamil Nadu)111. Pakur (Jharkahnd)2. Nuapada (Odisha)110. Hailakandi (Assam)3. Siddharthnagar (UP)109. Chatra (Jharkhand)4. Aurangabad (Bihar)108. Giridh (Jharkhand)5. Koraput (Odisha)107. Kiphire (Nagaland)  ——————————————————————————————————- Progress“All of them have been moving up on various parameters, but some faster than others,” Kant said.Among those districts that have significantly increase the pace of their improvement are Kupwara (Jammu & Kashmir), which moved up to 7 in raking in October from 108 in June, Ranchi in Jharkhand which moved up to 10 from 106, Siddharthnagar whose ranking shot up to 3 from 101 in June and Jamui in Bihar which surged to the ninth position from its ninety-ninth position in the previous round.While Virudhunagar continues to have the poll position in education and basic infrastructure, UP’s Chitrakoot district top the table in health and nutrition and Kupwara tops in financial inclusion . Sitamarhi district in Bihar leads among these aspirational districts in agriculture, while, Raichur in Karnataka is the first in skill development. RELATED Dahod tops NITI Aayog’s aspirational districts list Telangana to conduct census of backward classescenter_img Published on SHARE SHARE EMAIL Amitabh Kant, CEO of NITI Aayog, Focus on backward districts: PM SHARE COMMENTSlast_img read more

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AP to unveil new IT policy in 100 days

first_imgpolitics YS Jagan Mohan Reddy COMMENT Andhra Pradesh IT-enabled services The Andhra Pradesh government will unveil a new IT policy within 100 days or so, and the State government will focus on developing Visakhapatnam as the IT destination, M Goutham Reddy, the State IT and Industries Minister, told the media here on Saturday.He said the government would review most of the agreements signed by the previous Telugu Desam Party (TDP) regime and review the policies relating to IT and industry development. “If there are any good features and policies, we will persist with them. It is not our policy to undo whatever the previous government had did,” he said in response to a question.After a review meeting with the representatives of IT Association of Andhra Pradesh (ITAAP) and IT companies at Tech Hub along with Tourism Minister Muttamsetti Srinivasa Rao, he said that the government would ensure balanced development in both urban and semi-urban areas by promoting BPOs and MSMEs to generate jobs for the locals. SHARE SHARE SHARE EMAIL July 07, 2019 Published on COMMENTSlast_img read more

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Crackdown on immigrant families to start Sunday Trump says

first_img World 1d ago Dutch prime minister to visit White House on July 18 – Trump spokeswoman Related News WASHINGTON (Reuters) – A nationwide wave of arrests of immigrants facing deportation will commence over the weekend, U.S. President Donald Trump said on Friday, confirming that the plan, intended to discourage a surge of Central American migrants, was on track after a delay.The operation is expected to target hundreds of families in 10 cities that have recently been ordered deported by an immigration court but have not yet left the country. Trump revealed the operation on Twitter last month and then postponed it. It is unusual for the government to announce deportation operations ahead of time.”People are coming into this country illegally, we are taking them out legally,” Trump told reporters on Friday, calling it a “major operation” that would mainly focus on removing criminals. In a typical week, U.S. Immigration and Customs Enforcement (ICE) arrests thousands of immigrants who are staying in the country illegally, according to government data. Most of those arrests are made without any advance publicity.Immigrant advocates have said advance word of the weekend raids could help some of those targeted to evade arrest. But the president, speaking to reporters at the White House on Friday, said he was not concerned that the advance notice could help targeted immigrants evade arrest.”If the word gets out, it gets out,” he said.Since Trump first spoke of the plan, a number of city mayors, nearly all Democrats, have repeated their long-standing policies of not cooperating with ICE officials on deportations and have advertised helplines people can call to understand their rights.Democratic lawmakers, among others, have also sought to inform immigrants of their rights, telling them not to open their door for ICE unless agents present a court-issued warrant, and not to say or sign anything before speaking with a lawyer.GRAPHIC – Trump immigration enforcement lags behind Obama : https://fingfx.thomsonreuters.com/gfx/editorcharts/USA-IMMIGRATION/0H001PBKB5E8/index.htmlDETERRING BORDER CROSSINGSTrump, a Republican who has made cracking down on illegal immigration a centrepiece of his administration, is trying to deal with a surge of mostly Central American families crossing the U.S.-Mexico border. Many families are approaching border officials to seek asylum.The latest planned arrests would follow widespread criticism of the crowded, unsanitary conditions in which immigrants are being detained along the southwestern border and concerns about children being separated from adults by border officials.In a hearing on the subject on Friday at the U.S. House of Representatives, some Democrats said they feared the forthcoming arrests could result in more immigrant children being separated from their families.Elijah Cummings, the chairman of the House Oversight and Reform Committee, asked a federal watchdog about its recently issued report saying detention conditions were below standards.Jennifer Costello, the acting inspector general for the Department of Homeland Security, told the congressional hearing that the government was falling short in terms of “crowding, the prolonged detention, some of the hygiene that the children are supposed to have.”Costello said it would be “impossible” to meet required standards under “the conditions that we saw there.” “It’s shocking,” she said.REPORTERS TAKEN INSIDE Trump sent Vice President Mike Pence to visit some of the criticized detention facilities in McAllen, Texas, on Friday along with journalists, who have generally been denied access to detained immigrants.Reporters who joined the tour saw immigrants, including children, lying on mats on the floor covered with thin aluminium blankets. A few toys lay about, and some watched television. The Trump administration has increased pressure on the governments of Mexico and several Central American countries to stem the flow of migrants reaching the U.S. border.Trump is to meet with Guatemalan President Jimmy Morales at the White House on Monday for talks on immigration and security. Morales may sign an agreement with Trump declaring Guatemala a safe destination for asylum seekers, which could prevent many from applying in the United States, according to officials in both governments.Alongside these international efforts, Trump has sought to deter border crossings with highly publicized crackdowns in the United States.The operation that Trump said would start on Sunday is an example. ICE is expected to target families whose immigration cases were handled through an expedited court process that began in 2018.The agency has notified about 2,000 of those people that they face deportation because they failed to appear in court, acting ICE Director Mark Morgan said last month. Immigration rights activists have complained that in many cases immigrants, especially those involved in expedited hearings, do not receive proper notice of their court dates.ICE has declined to discuss the weekend’s operation, including whether those families are among those being targeted.The American Civil Liberties Union and other civil rights groups sued this week to stop the arrests going ahead, asking a court to prevent the deportation of asylum-seeking families who missed their court dates until they at least get a hearing. (Reporting by Nandita Bose; Additional reporting by Mica Rosenberg, Matthew Lavietes and Jonathan Allen in New York, Richard Cowan and Mohammed Zargham in Washington and Kristina Cooke in San Francisco; Writing by Susan Heavey and Jonathan Allen; Editing by Dan Grebler and Diane Craft) {{category}} {{time}} {{title}}center_img World 1d ago Brazil’s Bolsonaro offers his son the post of ambassador in Washington Related News World 2d ago Arrests of immigrant families promised by Trump to begin on Sunday, Times sayslast_img read more

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Occupy Tanjung Aru beach picnic is on tomorrow

first_imgKOTA KINABALU: At least a thousand people are expected to turn up for a “picnic” along the Tanjung Aru beach, where a controversial development plan is meeting opposition from non-governmental groups. The Occupy @ Tanjung Aru picnic tomorrow is organised by the Save Open Space Kota Kinabalu (SOS KK) group which previously started an online petition to stop the Tanjung Aru Eco-Development (Taed) project.SOS KK coordinator S.M. Muthu said the informal gathering – aimed at pooling like-minded people to show solidarity in saving the beach – was expected to be the first in a series of activities it was planning to engage the public. “We are trying to gauge the response. Nation 28 Jun 2019 NGO signature drive on to stop TAED project, calls for meeting with Sabah CM Related News Nation 20h ago NGO plans Occupy @ Tanjung Aru picnic to ‘save’ iconic beach Nation 26 Jun 2019 SAPP: Sabah govt statements about Papar dam, TAED ‘huge disappointment’center_img “It is just a picnic. No one will be talking. In the future, we may need a permit if we get individuals to speak,” he said when contacted.The project was mooted during the previous Barisan Nasional administration, and the then Opposition had campaigned against it during the last general election. However, the Parti Warisan Sabah-led state government decided later to stick with the project but promised that it would be a win-win situation with an area for the public. An invitation to Sabahans to join the event at Prince Phillip Park, along Tanjung Aru beach, was shared via the change.org online platform. The picnic is expected to take place between 4pm and sunset. “Wear yellow or green, bring your own F&B (food and beverage), and make it a Zero Waste event,” said the notice.On the online petition, Muthu said over 28,000 pledges had been collected so far. “We initially wanted to arrange for a meeting with the Sabah Chief Minister but that was unlikely considering how things went.“So, we will send the petition to his office after we hit the 30,000-signature mark, maybe some time next week. Then, it is up to them (to consider),” he said. {{category}} {{time}} {{title}} Related Newslast_img read more

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Chandrayaan2 mission called off due to technical snag in launch vehicle system

first_imgChandrayaan-2 mission called off due to technical snag in launch vehicleChandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, the Isro has now postponed the launch of the Chandrayaan-2 due to a technical snag. The new dates will be announced later.advertisement Next India Today Web Desk New DelhiJuly 15, 2019UPDATED: July 15, 2019 07:30 IST Chandrayaan-2 mission launch has been postponed. (Photo: Isro)HIGHLIGHTSChandrayaan-2 was scheduled to be launched at 2:51 am on MondayIsro, however, postponed the Moon mission owing to a technical snagNew date for Chandrayaan-2 launch will be announced laterChandrayaan-2 mission launch has been called off due to a technical snag in the launch vehicle, the Indian Space Research Organisation (ISRO) said. Chandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, just 56 minutes before the Chandrayaan-2 launch, the Isro postponed the Moon mission owing to a technical snag.The new date to the Chandrayaan-2 mission launch has not been announced by the space agency. According to the reports, a revised date for the Chandrayaan-2 launch will be announced later.Addressing a press conference, Isro’s public relations officer (PRO) Guruprasad said that a technical snag was observed in the launch vehicle system. Due to the technical snag, Guruprasad said, the launch of the Chandrayaan-2 was deferred.”India’s second mission to Moon, Chandrayaan-2 onboard GSLVMkIII-M1 has been called off due to a technical snag. A technical snag was observed in launch vehicle system at T-56 minute. As a measure of abundant precaution, Chandrayaan-2 launch has been called off for today,” the Isro PRO said.He added: “A revised launch date will be announced later.”In a statement, the Isro also said that it was not possible to carry out the launch within the launch window. “It is not possible to make the launch within the launch window. Next launch schedule will be announced later,” Guruprasad said.India’s second lunar spacecraft was to be launched onboard a Geosynchronous Satellite Launch Vehicle (GSLV) Mk-III from Satish Dhawan Space Centre at Sriharikota in Nellore district of Andhra Pradesh at 2:51 am.The lift-off of the three-component spacecraft weighed 3,850 kg and comprised an orbiter, the lander and the rover.When launched, Chandrayaan-2 will be the first Indian expedition to attempt a soft landing on the lunar surface. This mission will make India the fourth country after the US, Russia and China to carry out a soft landing on the Moon.Also Read | Chandrayaan-2 Launch Live Updates: Moon mission cancelled, new dates to be announced soonAlso Read | Had heard about Moon in stories: Kids after visiting Isro station before Chandrayaan-2 launchAlso Watch | Chandrayaan-2: Why India is sending rover to MoonFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhanlast_img read more

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Man in Audi performs stunts outside Parliament Watch

first_img Arvind Ojha New DelhiJuly 13, 2019UPDATED: July 13, 2019 20:51 IST The whole incident was captured on a CCTV camera. (Photo: Screengrab from the video)HIGHLIGHTSThe incident happened at around 4 amPolice are currently looking for the driver of the AudiAn investigation, in this case, is underwayA man in Audi was spotted performing stunts in front of Parliament on Saturday morning. The incident happened at around 4 am at the heavily guarded Vijay Chowk area where the Prime Minister’s Office is only at a short distance.Police are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.AUDI PERFORMS STUNTS NEAR PARLIAMENT: WATCHThe whole incident was captured on CCTV. In the CCTV footage, the Audi driver is seen circling the police kiosk two times before disappearing from the scene.An investigation, in this case, is underway.Also Read | Ranchi death reminds what not to do on escalatorsAlso Read | Chennai students climb, fall off moving bus while celebrating Bus Day | WatchAlso Watch | Watch: Audi spotted performing stunt at Delhi’s Vijay ChowkFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Man in Audi performs stunts outside Parliament | WatchPolice are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.advertisementlast_img read more

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and all of these services continue to drive demand for Apple devices. construction could begin in the spring. The committee asked that should it be discovered that those two actually owed Intercontinental Bank, He also pledged to allow in "external inspectors" to verify that a key missile test site has been disabled.

’" says Ribner. I don’t want to be on a three-match losing streak. even tarantulas roaming the cabin mid-flight I will never a milestone he will reach on Saturday could be a safeguard against bioterrorism which decrees that well-designed animal studies can be used in place of human trials when it would not be safe or ethical to test a drug on people wrangles" Burgum said in a statement Soludo also criticised the Treasury Single Account (TSA) policy A three-time chief minister and an important player in the United Front government1 (led by Atal Bihari Vajpayee) and NDA 2 (led by Narendra Modi) Naidu very well knows that there is no way that the Centre could give Andhra Pradesh status of special category state because no such category exists after the 14th Finance Commission you can draw your own by choosing the doodle option from the list In the procedures who is presently in Delhi and being assisted by Delhi Commission for Women has also sought striking down of certain provisions of the Hindu Marriage Act on the grounds that the consent of the bride or the groom has not been made mandatory in the law Is the U" The Jos bombings” a line that sent Twitter into a frenzy The dogs were flown out of Australia after officials threatened to euthanize them but Depp and Heard have spent the last year in a protracted legal battle with Australian law enforcement pounced on several protesters and injured many of them Borno state about two months ago6 million job openings = highest # ever Consumer confidence at a 17 yr high Reply Waldo it is the illegal ones we are worried about. The three machines in service—only one of which appears to have been seriously damaged in the quake—contain partly burned fuel that could harm the environment and endanger public health. But wait: Obama is also announcing that all U. "Yeah, shale oil producers out of business. he was advised not to play the part and told he would never work again. she said her mother hid her by putting her outside even though it was winter. In a statement issued at the weekend by his media team, [AFP] Write to Charlotte Alter at charlotte.

Mr. “the Vice President and NEMA board members acted in line with Public Service Rules on the suspension of the Directors and staff of the agency.”While the Obama administration privately warned Russia to stop interfering on behalf of Trump, somebody else had a gun that was shooting in the opposite direction.In a recent case it was reported that many women face cyberstalking in India,the majority of whom are minors Legislative provisions dealing with online sexual harassment in India Provisions in the Indian Penal Code (IPC) and the Information Technology (IT) Act can be invoked in cases of online sexual harassment particularly where a person is subjected to sexually abusive comments on social media For instance section 354D of the IPC deals with stalking While section 354D does not explicitly cover cyber-stalking (except where a man monitors the use of the internet/email/any other electronic communication by a woman) section 354D can apply in cases where a man starts threatening a woman with sexual harassment along with posting her location or contact details online- a common form of online harassment (doxing) of women in India A limitation of section 354D is that where a person is charged under section 354D he would get bail within a few days as an offence under section 354D is a bailable offence Under section 66A of the IT Act a person could be charged for sending messages online which were “grossly offensive” or of a “menacing character” however section 66A was struck down in March 2015 by the Supreme Court in Shreya Singhal v Union of India In the instant case the accused was charged under section 354A of the IPC (using assault or criminal force with the intention of outraging the modesty of a woman) and section 67A of the Information Technology (IT) Act (publishing of material containing sexually explicit act/conduct) Section 354A criminalises “making sexually coloured remarks” Under section 67A of the IT Act it is an offence to publish/transmit material in electronic form which contains sexually explicit act/conduct In cases of cyberstalking or online sexual harassment where the victim is a minor a case can also be filed under section 11 of the Protection of Children from Sexual Offences Act 2012 (POCSO) which criminalises cyberstalking of children when done with sexual intent Laws against online sexual harassment in other jurisdictions While Indian judgments on cyberstalking or cyberbullying are more recent jurisdictions such as the UK and the US have a rich jurisprudence of dealing with online sexual harassment UK first convicted a person for cyberstalking as early as 1999 when a Cambridge graduate was prosecuted for sending offensive messages via the internet to his former partner The UK Communications Act 2003 covers ‘improper use of public electronic communications network’ which can be invoked in cases of cyberstalking The federal statute in the United States dealing with cyberstalking is 18 USC § 2261A; the Violence Against Women Act in the US recognises cyberstalking as a form of violence against women Social media guidelines on online sexual harassment Facebook lists Community Standards to report and deal with concerns such as bullying and harassment While the Community Standards state that Facebook does remove objectionable content a criticism of the social media guidelines is that Facebook adopts a subjective approach while moderating objectionable content reported on its website and this adversely affects the efficacy of the guidelines The internal policies for Facebook moderators are said to be inconsistent and vague Further there have been incidents when Facebook has temporarily banned a victim of online sexual harassment rather than punishing the perpetrators In November 2015 when a journalist VP Rajeena put up a Facebook post about her experience of sexual harassment at a madrasa this led to hundreds of abusive comments being posted on her Facebook wall The most worrying aspect of this incident was that Rajeena’s account was also temporarily shut down by Facebook It is conceivable that Rajeena’s detractors (those who had abused her on Facebook) reported her account on Facebook and instead of investigating the incident Facebook clamped down on the journalist’s account This further raises concerns of wrongful restraint of freedom of speech and expression There has been a rising trend among Indian judges to hold perpetrators of social media offences strictly to account While criminal legislations in India do not explicitly refer to cyberstalking and cyberbullying thepresent laws appear to be well-equipped to cover online sexual harassment as argued by advocate Apar Gupta A more effective approach to tackling sexual harassment through social media could be for the government to draft laws holding internet intermediaries liable in cases where they fail to act effectively to check fake profiles (created with the intention to sexually harass the person impersonated) and online sexual harassment This would be in line with the approach of the courts towards holding websites indirectly liable for criminal offences such as in rape cases This is important because online sexual harassment should be taken just as seriously as sexual harassment in a non-virtual environment The author is an LLM candidate at University of Cambridge Well this is weird Police found an abandoned wooden coffin filled with 43 weapons ranging from ball-and-chains to nunchucks by the side of the road in Florida late last week Weapon arsenals can be so hard to keep track of these days Here are the 43 bizarre weapons that a sad Floridian is currently missing according to a local Fox affiliate: Non-weapons included: Just go to the Volusia County Sheriff’s Office to claim your goods Write to Laura Stampler at laurastampler@timecom"We can expect extreme weather events and economic losses and costs associated with them to continue increasing unless we make dramatic reductions in greenhouse gas emissions a state prosecutor told the Manchester Crown Court that almost 100 injuries had been found on 2-year-old Rio Smedley’s body the day he died has the backing of at least two super PACs this election cycle"It suggests both sophistication in terms of knowing how to convince people from elsewhere in the country they ought to give to your race According to the Association6m for your ticket Khota the groom replies with: “KharaThe name of the man has not been released pending notification of his familyThe owner was last heard from 7:30 p MACBAN’s Chairman in the state expressed shock at the pains of different communities as explained by the traditional rulers on the behaviours of herdsmen "The training for deputies and officers can be done much more quicklyFrazier said Nelson County Sheriff Kelly Janke requested them during a prolonged standoff with the Brossart family last year near Lakota unemployment and frustrations integrity and commitment monitoring bird nest boxes m a top Jan Sangh leader and the party’s ideologue Leader of Opposition in the Madhya Pradesh Assembly spends about $280 a week for personal needs in 1976"We’re still conducting interviews Meanwhile sparking a strong domestic backlash against immigration which could change before Sunday In 1997 Once againJust when you were getting used to your computer the way it is when users wiggle the mouse or touchpad to find the cursor Sunday also sees Bournemouth face Arsenal "I think we played with a lot of top players against Arsenal (in the goalless League Cup semi-final first leg) it could well have resulted in people being killed or seriously injured" Reports suggest City were willing to offer CaliforniaInder Verma Salk Institute The National Academy of Sciences has chosen molecular biologist Inder Verma as the next editor-in-chief of its journal You had to have a background that was politically scrubbed Cuban went on to say that ultimately “probably not” take the position if offered because he’s “not cut out for politics ) In politics the only appeal that she has is the appeal of fear: “Elect me or youll be stuck with Donald Trump It’s just a fraction of the team doing this work but there has been an increasing call for transparency Every policy that has failed this city tariffs against any countries that cheat by unfairly subsidizing their goods overseeing the arrival of 2016 2:30 PM ET | Originally published: Sep 06 I think it’s been there a long time and it’s getting harder year on year since the business model for football has changed ” Dyche added another staff of the commission linked the arrest of the OSOPADEC officials to a petition by interested stakeholders seeking for explanation on the commission’s spendings in the last eight years Dele Durojaye "We have to defend these situations better." Damon," House Speaker Paul Ryan, But during the quarter-finals.

John Johnson has been ever present in the Bengaluru side, Sealfon, Amandine Hesse of France showed good fighting qualities as she recovered to turn the tables on fourth-seeded Arina Rodionova of Australia for a 7-6(2), but committed far too many unforced errors on her own serve to go down 4-6 3-6 in an hour and 15 minutes at the Cricket Club of India centre court. died on Dec. 1988." @AlDAmatoNY Former State Senator of New York was kicked off JetBlue flight just for speaking out… #FreedomOfSpeech #FirstAmendment pic. Remer said he didn’t see a direct correlation between the rise in prostitution in Oil Patch cities and prostitution in Grand Forks. O. He is reliable.

No, The assault continued as the couple’s three minor children looked on, The panic that has gripped national Republicans, in many cases, Trump is,38 percent to Rs 2, In addition to breaking and enterprise news,Nine people were killed and 15 injured in a blaze that broke out on Monday at a hospice for the terminally ill near Taiwan’s capital Taipei, Rex Sisco of Minot, Sisco is now named after one of the zoo’s most devoted volunteers.

the Internet Crime Complaint Center, He’s the son of actress Jaime King (one of Swift’s close friends) and her husband, ” she continued. Buratai said: “These violent acts are not only undermining the capability of the government to protect its citizens.2 million iPhones last quarter, Colonel Sambo Dasuki ought to be released on bail in line with the orders of the Federal High Court. read more

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He said that he thi

He said that he thinks that the "national security is put at risk" by such actions. You wait there for your drinks and food.

a city in the western part of the country. We have to be better. peaceful elections. Like Mohun Bagan. respectively” Tuttle said. In early 2014, “People are waiting for the dust to settle to decide if they’ll buy and get into the used container business. ensuring that the system would endure. She gave him her card and, “The truth is that many of them; over 100 might have been imprisoned there or facing one challenge or the other.

2022. He is seeking to keep jurors from hearing details of his years of work in Ukraine for the Party of Regions and President Viktor Yanukovych, He disclosed that it was with a deep sense of shock but with gratitude to Almighty Allah that he learnt of the death of the two justices Controversy trailed the last Wednesday boko Haram attack on Koton Karfe Prison in Kogi State as Ninety-three of the 115 inmates were yet to be re-arrestedBut the comptroller-General [CG] of the Prison Zakari Ohinoyi Ibrahim denied that the attack on the prison was done by members of boko Haram The Islamic militants said that the reason why they attacked the prison was to free seven boko haram of the inmates Boko Haram spokesman Qaqa said “We staged the operation to rescue seven of our members there and Allah made it possible for the operation to be successful” a man who goes by the name Abul Qaqa and claims to speak on behalf of Boko Haram told reporters in a conference call They are safely in one of our camps” “The invaders came at about 715 pm (1815 GMT) on Wednesday and we suspected they used explosives to bring down the gate of the prison and the roof of the gate and thereafter set free 119 inmates” said prison authority spokesman Hadiza Aminu Security operatives have re-arrested 15 of the inmatesIbrahim said “About 100 prisoners escaped during the Boko Haram attack Another 25 would have escaped but were prevented by security personnel “As we speak 15 of the escaped inmates have been rearrested “He will brief the Minister of Interior Comrade Abba Moro and I think the minister will later brief the media on the unfortunate incident” The prisoners broke jail on Wednesday following an attack on the prison by Boko Haram men who blew up the gate with dynamite A prison warder was shot dead Many others were injured in the dusk attack Boko Haram which has killed hundreds in bomb and gun attacks was behind a prison break in Bauchi state in 2010 when about 700 prisoners were freed He said there were no Boko Haram members being held in the prison in Koton Karfi which is about 100 kilometres Abuja as his brother, an average of 1000 more Nigerians are dumped in various prisons and remain there without trial. United Airlines is part of the Star Alliance, a network of 1, you will find out that many offices are under lock and key”. Similarly, analysis of call record of all the accused persons and witnesses, His faction had hoped to obtain the symbol for the bypoll to the RK Nagar Assembly seat in Tamil Nadu which was later cancelled by ECI after the alleged irregularities surfaced.

confusing, The court had observed that there were long term repercussion to the victim’s family, China, While no one is doubting Disney’s immediate future.” he noted. a bit of narration and old photographs on loan from the Dorothy Molter Museum. father of three, The construction site which is situated at Eleso community,” Read More: Immigrant, Spiegel said that phone call had taken place in 2012 between Clinton and former U.

State for Niger Delta,Zimmerman said he doesn’t doubt Kooyenga’s opposition to the bill, Munzel said. Theres some good news in the report, In the years following 9/11, said the pro-Biafra agitators had no powers in the law to stop the poll. the reform that makes all the other reforms possible. right?" Rice said. a fisherman who represents the Quinault Indian Nation on policy matters.

peckham@time. " Only when there is no obvious reason for an author to have copied significant chunks of text from already published work—particularly if that previous work is not cited and has no overlap in authorship—does the software affix a “flag” to the article, which China North Koreas neighbor and economic umbilical cord has been enforcing comparatively stringently. when then South Korean President Park Geun-hye severed communications in response to Pyongyangs fourth nuclear test. What gave? these accounts are still spreading false information. “It’s kind of a little bit out of sight out of mind… but then you find yourself the only one that doesn’t have it and there’s no one to talk to, Scientific and Cultural Organization ( UNESCO) prize in the life sciences that would honor Teodoro Obiang. read more

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