Reviewed by James Ives, M.Psych. (Editor)Oct 29 2018Blood pressure readings of 130/80 millimeters of mercury (mm Hg) or higher taken at home can be used to diagnose hypertension in white, black and Hispanic U.S. adults, according to new research in the American Heart Association’s journal Hypertension.”Until now, recommendations for diagnosing high blood pressure with measurements done at home were primarily from Japanese and European studies,” said Wanpen Vongpatanasin, M.D., study author, professor of medicine and hypertension director at UT Southwestern Medical Center in Dallas. “We didn’t know if these recommendations actually applied to U.S. adults.”Researchers analyzed large multi-ethnic studies that compared home blood pressure to clinic measurements of primarily young and middle-aged adults in Dallas, Texas and Durham, North Carolina. In 420 participants in the North Carolina clinic, high blood pressure readings (130/80) were confirmed with similar readings at home. In 3,132 participants in the Dallas study, researchers determined risks of stroke, heart attack and death associated with a clinic systolic blood pressure reading of 130 mm Hg. During the 11-year follow up, researchers also determined that people with high blood pressure levels measured at home had the same heart disease risk as people with similar levels measured by medical professionals.Related StoriesBlood pressure self-monitoring can help patients with hypertension to stick with exercise programMathematical model helps quantify metastatic cell behaviorDon’t ignore diastolic blood pressure values, say researchersVongpatanasin added that the findings correlate with the American Heart Association/American College of Cardiology 2017 blood pressure guideline.”It’s important to measure blood pressure at home because clinic readings might not reflect a person’s true blood pressure. Some people have higher readings in the clinic because of the ‘white coat’ phenomenon, while studies have shown that others – especially, blacks – have lower blood pressure readings in the clinic than at home,” she said.This study included adults aged 30 to 65 years old from two U.S. cities, so the findings might not apply to younger or older people or adults in different geographical areas, she said.With the definition of high blood pressure set at 130/80 mm Hg, nearly half (46 percent) of U.S. adults have high blood pressure. Researchers have found that at least 30 percent to 45 percent of U.S. adults with hypertension monitor their blood pressure at home.The American Heart Association recommends consumers follow the proper technique when measuring blood pressure: be still and rest quietly for at least 5 minutes before measurements; avoid caffeine or cigarettes in the half hour before your reading; keep both feet flat on the floor; and avoid talking during the test. At least two readings should be taken one minute apart in the morning before taking medications and in the evening before eating. Ideally, blood pressure readings should be taken during one week beginning a few weeks after a change in the treatment regimen and during the week before a doctor’s visit. Source:https://newsroom.heart.org/news/home-monitoring-confirms-clinic-diagnosis-of-high-blood-pressure?preview=3656
Reviewed by James Ives, M.Psych. (Editor)Jul 9 2019Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone. Taylor and Dr. L.M. Viranga Tillekeratne, a professor in the Department of Medicinal and Biological Chemistry in the UToledo College of Pharmacy and Pharmaceutical Sciences, reported their findings in a paper recently published in the journal Scientific Reports.Cancer stem cells are an intriguing target for researchers because of their potential to re-seed tumors.When doctors remove a tumor surgically or target it with chemotherapy drugs or radiation therapy, the cancer may appear to be gone. However, evidence suggests that a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations.Those cancer stem cells, Taylor said, are similar to dandelions in a well-manicured lawn.”You could chop the plant off, but it will drop a seed. You know the seeds are there, but they’re hiding,” he said. “You pull one weed out and another comes up right after it. Cancers can be like this as well.”Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe small molecule they have isolated appears to lock on to those stem cells and kill them by blocking their absorption of an amino acid called cystine.UToledo was awarded a patent for the discovery late last year.For Tillekeratne and Taylor, uncovering a new class of therapeutic molecules could prove to be an even larger contribution to cancer research than the project they initially envisioned.”At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research. This also shows the beauty of collaboration. I wouldn’t have been able to do this on my own, and [Taylor] wouldn’t have been able to do it on his own.”Tillekeratne has received a three-year, $449,000 grant from the National Institutes of Health National Cancer Institute to continue testing the effectiveness of the newly identified therapy.Because the molecules so selectively target cancer stem cells, it’s possible they could ultimately be paired with other chemotherapy drugs to deliver a more comprehensive treatment.However, the researchers have found their agents show stand-alone promise in treating sarcomas and a subtype of breast cancer known as claudin-low breast cancer, which represents up to 14 percent of all breast cancers and can be particularly difficult to treat. Source:University of ToledoJournal reference:Taylor, W.R. et al. (2019) Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific Reports. doi.org/10.1038/s41598-019-42251-5. Not all cancer cells are the same, even in the same tumor. There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”Dr. William Taylor, professor in the Department of Biological Sciences, UToledo College of Natural Sciences and Mathematics
Chandrayaan-2 mission called off due to technical snag in launch vehicleChandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, the Isro has now postponed the launch of the Chandrayaan-2 due to a technical snag. The new dates will be announced later.advertisement Next India Today Web Desk New DelhiJuly 15, 2019UPDATED: July 15, 2019 07:30 IST Chandrayaan-2 mission launch has been postponed. (Photo: Isro)HIGHLIGHTSChandrayaan-2 was scheduled to be launched at 2:51 am on MondayIsro, however, postponed the Moon mission owing to a technical snagNew date for Chandrayaan-2 launch will be announced laterChandrayaan-2 mission launch has been called off due to a technical snag in the launch vehicle, the Indian Space Research Organisation (ISRO) said. Chandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, just 56 minutes before the Chandrayaan-2 launch, the Isro postponed the Moon mission owing to a technical snag.The new date to the Chandrayaan-2 mission launch has not been announced by the space agency. According to the reports, a revised date for the Chandrayaan-2 launch will be announced later.Addressing a press conference, Isro’s public relations officer (PRO) Guruprasad said that a technical snag was observed in the launch vehicle system. Due to the technical snag, Guruprasad said, the launch of the Chandrayaan-2 was deferred.”India’s second mission to Moon, Chandrayaan-2 onboard GSLVMkIII-M1 has been called off due to a technical snag. A technical snag was observed in launch vehicle system at T-56 minute. As a measure of abundant precaution, Chandrayaan-2 launch has been called off for today,” the Isro PRO said.He added: “A revised launch date will be announced later.”In a statement, the Isro also said that it was not possible to carry out the launch within the launch window. “It is not possible to make the launch within the launch window. Next launch schedule will be announced later,” Guruprasad said.India’s second lunar spacecraft was to be launched onboard a Geosynchronous Satellite Launch Vehicle (GSLV) Mk-III from Satish Dhawan Space Centre at Sriharikota in Nellore district of Andhra Pradesh at 2:51 am.The lift-off of the three-component spacecraft weighed 3,850 kg and comprised an orbiter, the lander and the rover.When launched, Chandrayaan-2 will be the first Indian expedition to attempt a soft landing on the lunar surface. This mission will make India the fourth country after the US, Russia and China to carry out a soft landing on the Moon.Also Read | Chandrayaan-2 Launch Live Updates: Moon mission cancelled, new dates to be announced soonAlso Read | Had heard about Moon in stories: Kids after visiting Isro station before Chandrayaan-2 launchAlso Watch | Chandrayaan-2: Why India is sending rover to MoonFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan
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modern "lazy" disease is getting worse, but it also spawned a lot of business opportunities. Dry cleaning is due to the cause of the modern "lazy" and the birth of washing clothes, why dry cleaning industry has a very good prospects for development?
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