Tag: 上海419论坛

Merrimack Valley Acappella Chorus To Collect Soft Goods For Savers Fundraiser This

first_imgWILMINGTON, MA — The Wilmington-based Merrimack Valley Acappella Chorus is collecting donations of soft items to this Saturday, September 29, 2018, from 9:30am to 11am, at the Wilmington Arts Center (219 Middlesex Avenue).Soft items include clothes, shoes, hats, bags, and linens/towels. In conjunction with Savers of Wilmington, every bag dropped off at the Arts Center will help raise money for the chorus to help cover the costs of rehearsal space, costuming, coaching, music, transportation, and more.(NOTE: The above announcement is from the Merrimack Valley Acappella Chorus.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedThe Wilmington Insider For September 29, 2018In “5 Things To Do Today”Merrimack Valley A Cappella To Perform At Wilmington Farmers Market On July 21In “Community”Merrimack Valley A Cappella To Run FREE Workshops For Middle School & High School Female Singers In WilmingtonIn “Community”last_img read more

Read More

Taj Mahal Worlds most photographed monument

first_img“It’s a matter of pride to be photographed with the Taj Mahal,” said Denis, a tourist from Australia. These days, with almost every one in possession of a mobile or a digital camera, you can see people taking selfies or posing for a group photograph with friends or relatives. Now with the Taj Mahal getting its own Twitter handle and the monument complex equipped with WiFi facility, no one misses the once-in-a-lifetime opportunity to shoot and share. The Taj has not lost its charm. It continues to remain the delight of photographers from all over the world.  Also Read – ‘Playing Jojo was emotionally exhausting’Lonely Planet’s ‘ultimate travel list’ includes the Taj in the top five tourist destinations in the world. The Taj Mahal is annually visited by over six million people. Unofficial figures are 10 million, as children below 15 do not have to purchase a ticket to enter.Each day hordes of photographers — both amateurs and professionals — shoot pictures of the white marble mausoleum, bringing joy and excitement to those who pose against its backdrop. “Many feel it’s a fulfilment of a long-cherished dream,” said Amit Sishodia of Agra Beats travel agency. Also Read – Leslie doing new comedy special with Netflix“It’s the architecture, the perspective and the unique backdrop that includes the Yamuna and a whitish skyline that appears to extend to eternity that I find most appealing,” said a city photographer Hemant. Ramesh Chandra Khandelwal, aged 90 plus, Agra’s oldest photographer who runs the more than a century old firm of Priya Lal and Sons, said the Taj Mahal will never lose its fascination and awe.“It is one building with immaculate, Nayaab dimensions, perfect lighting conditions, such variety of angles and contrasts, what else could a photographer want? And if you take into account its history and the romanticism associated with it, who would not like to be photographed with it,” said Khandelwal.  Wildlife photographer Lalit Rajora, who began his journey 18 years ago from the Taj Mahal, still cannot delink himself from the grand Mughal monument.“The grand Taj Mahal, with its enticing beauty, has an eternal fascination for me. Its aesthetic beauty, pristine craftsmanship and grandeur attracts me as a photograph does. As a photographer, when this attraction converted into an unfading romance and passion is difficult to tell. All I can say is that the Taj, under the seasonal hues of the sky enkindles my soul, gives wings to my imagination and meaning to my expression and creativity,” said Rajoria.Vijay Goyal, owner of the Speed Colour Lab, who spent 20-odd years at the Taj Mahal, shooting pictures for tourists and VIPs, said “I recall the statement of a lady tourist long back. She reacted: ‘Oh my god, this looks much better than the photograph I saw back home’.”Goyal said the Taj Mahal faces south. “The sun rises from the east on the left and traverses the whole distance to the right (west) providing different contrasts, shades and colours —never a dull moment. Each angle is different, its symmetry and geometry is perfect and flawless. There is a mix of colours — red sand-stone juxtaposed with white marble and a profusion of green vegetation, while the shades of blue and white. Rare is a man-made structure in the world that provides such a spectacular variety and mind you, there is no artificial lighting anywhere as for the Eiffel Tower or many other monuments.”last_img read more

Read More

Youth hit on the head for abuse protest

first_imgKolkata: A youth from Sonarpur in South 24-Parganas sustained head injuries after being hit on his head by a local miscreant. The incident occurred on Saturday morning when the victim protested against the accused as he was hurling abusive language at his wife. The accused has been arrested. Police said the victim, identified as Susanta Mondal protested against the accused, Madan Mondal who had allegedly abused his wife. A heated altercation broke out between the two when the victim demanded an apology from the accused. The altercation soon led to a scuffle following which the accused youth hit him on his head with a rod. One of the victim’s associates, Ram Naskar, who came to his rescue also received injuries in the incident. The accused fled the spot immediately after the incident but he was later arrested. The locals rushed both the injured victims to a nearby healthcentre. The locals told the police that the accused has been involved in various anti-social activities and often used to abuse women. A case has been initiated after the family members of the victims lodged complaints.last_img read more

Read More

TMC office ransacked Suvendu says BJP is very nervous

first_imgKolkata: The Trinamool Congress party office in Contai was ransacked and some vehicles parked outside set ablaze by alleged BJP supporters on Tuesday evening.Suvendu Adhikari, the state Transport minister, stated that BJP supporters, after attending Amit Shah’s rally, ransacked the party office along with several nearby shops. Some bikes were also set on fire. There were long queues of cars on Contai bypass and the miscreants broke the windscreens of many of them that were caught up in the traffic jam. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killed”We do not believe in violence. Or else, we could have taught them a lesson. Such incidents are uncalled for and unfortunate. BJP is losing ground everywhere and such incidents reflect the nervousness of the party,” said Suvendu. He further added: “The BJP should first concentrate on defending its government at the Centre. The people of this country have already made up their mind to vote them out.” “They (BJP) should stop lecturing others on democratic values and people’s rights. Had they provided good governance, they would not have been voted out in three Hindi heartland states (Rajasthan, Chhattisgarh and Madhya Pradesh in the December Assembly polls)”, he said. Meanwhile, Trinamool MP Sisir Adhikari alleged that the CPI(M) supporters who have recently joined the saffron party were behind the Contai ransack. The TMC will take out a rally condemning the incident on Wednesday.last_img read more

Read More

Four Tools for Improving Office Collaboration

first_img Laptops, smartphones, tablets and web-based apps let groups collaborate from virtually anywhere around the globe. But in-person collaboration has largely remained tech-resistant. Until now, that is.Say goodbye to disengaged team members who zone out when asked to stare at non-interactive presentation tools. A growing number of collaborative display devices are being designed to help promote teamwork and more productive meetings.Here are four tools to help you transform your conference room into a true collaborative space:The Steelcase media:scape table and teleconferencing tool1. Build an interactive environment.For some entrepreneurs, the traditional conference room setup of a big table and projector is no longer the best way to manage a team of employees and their mobile devices. Another option is to create a collaborative environment that lets you work more comfortably and conveniently from a variety of locations.For screen sharing, consider using a large display that everyone can see clearly and that can be easily connected to a variety of devices. Grand Rapids, Mich.-based Steelcase specializes in tech and team-friendly office arrangements. The company’s collaborative table and teleconferencing tool called media:scape lets up to four users plug in and share their own device screens — and audio — on a central display simply by pushing a button.Related: Five Ways to Boost Productivity with New Tech ToolsIn addition to the full-size conference style version, Steelcase comes in mini and mobile versions. Prices vary by configuration. How Success Happens The 3M Multi-Touch Display2. Get more hands-on.Large format touchscreens can be useful collaboration tools for side-by-side computer work. Touch displays, including the Multi-Touch Display from St. Paul, Minn.-based 3M, can turn any computer session into a shareable iPad-like experience. Touch-enabled monitors such as the 18.5-inch 3M Multi-Touch Display (about $1,175) allow multiple users to manipulate content on the screen without surrendering the mouse or keyboard.While it’s probably not practical for two or more people to work on one screen all the time, touch functions can be useful for graphic designers and other creative workers when they’re brainstorming on the same document.Related: Why Next-Gen Displays Might Be Your Next Point-of-Sale Marketing ToolA SMART interactive whiteboard system3. Try an interactive white board.Interactive whiteboards from companies such as Calgary, Canada-based SMART are similar to touch-based monitors, but large enough to allow groups to collaborate on digital content, including web pages and PDF files.These tools take the traditional white board up several notches. Groups can write directly on the display — mark up documents, make highlights or take notes — and the smart board will capture the changes.Basic interactive whiteboards from SMART start at about $1,000.The Samsung SUR40 ‘smart’ table4. Turn your conference table into a computer.Technology companies have transformed staid conference room tables into “smart” tables that can act as giant tablet computers. Simply pull up documents, images and other content directly to the table’s screen, and people can manipulate the items with their hands.Take for instance the Samsung SUR40, developed in collaboration with Microsoft. This device was designed as a customer engagement and marketing tool, but it also has potential as a next-generation collaboration platform.Related: Three Wild Tools from Tech EntrepreneursWhile smart conference tables can be useful for group review of content or face-to-face presentations in small groups, they aren’t inexpensive. The Samsung SUR40 retails for about $9,000.Bottom line: For businesses looking to fundamentally change the way they collaborate, these tools now make that possible. If any of them can turn just one good idea into a great one, the benefits can more than offset the initial cost. Listen Now 4 min readcenter_img February 29, 2012 Opinions expressed by Entrepreneur contributors are their own. Hear from Polar Explorers, ultra marathoners, authors, artists and a range of other unique personalities to better understand the traits that make excellence possible.last_img read more

Read More

Live News traffic and weather updates for North Staffordshire South Cheshire on

first_img Video Loading Video Unavailable Watch Next StokeonTrentLive – we’re #localandproud Share this video Click to playTap to play StokeonTrent Live – we’re #localandproudStokeonTrent Live – we’re #localandproudVideo Player is loading.Play VideoPauseUnmute0:00/1:20Loaded: 0%Progress: 0%Stream TypeLIVE-1:20 SharePlayback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedSubtitlessubtitles settings, opens subtitles settings dialogsubtitles off, selectedAudio Trackdefault, selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMute0:00/0:00Loaded: 0%Progress: 0%Stream TypeLIVE0:00 Playback Rate1xFullscreenClose Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.  Click for Soundcenter_img Watch again Video will play in  We pay for stories! Send your videos to video@trinitymirror.comHello and welcome to Stoke-on-TrentLive’s breaking news service bringing you all the latest updates from Stoke-on-Trent and North Staffordshire on Monday, November 12. Our team of reporters will be updating this live service with all the latest on the traffic and travel and weather updates – as well as news and entertainment through the day. We’ll be bringing you the very latest updates in our live news feed below. For the latest news and breaking news visit www.stokeontrentlive.co.uk Get all the big headlines, pictures, analysis, opinion and video on the stories that matter to you. Follow us on Twitter @SOTLive – the official Sentinel account – real news in real time. We’re also on Facebook – your must-see news, features, videos and pictures throughout Stoke-on-Trent, North Staffordshire & South Cheshire. Want to tell us about something going on where you live? Let us know – Tweet us @SOTLive or message us on our Facebook page . And if you have pictures to share, tag us on Instagram at StokeonTrentLive . 17:59All lanes reopenedAll lanes have now reopened.17:56Traffic held due to accident on M6A Highways England spokesman said:M6 northbound between J21 and J21A we have all traffic stopped due to a collision between a car and HGV. Delays building quickly on the approach. Please allow plenty of extra journey time. will keep you updated. “17:20Broken down vehicle causing delays on M6One lane blocked and slow traffic due to broken down vehicle on M6 Southbound between J18 A54 Middlewich Road (Middlewich / Holmes Chapel) and J17 A534 Old Mill Road (Sandbach / Crewe). In the roadworks area.Lane one (of three) is blocked.17:09Three remain in hospital two days after A53 horror crash killed 64-year-old womanPolice are appealing for witnesses or anyone with dashcam footage to come forward. More here.16:13Incident in Wolstanton involves minor injuries onlyWest Midlands Ambulance Service have confirmed they are treating two patients after an accident on High Street in Wolstanto – although neither are believed to have been seriously injured.A spokeswoman said:We were called just after 3.30pm. We had two ambulances and a paramedic officer on scene. Now there is just one ambulance and we are treating two patients.” 16:09Accident in Wolstanton involves car and pedestrianSlow traffic due to accident, pedestrian and vehicle involved on A527 High Street at B5368 Silverdale Road.Sources confirm there is no blockage on the road however delays remain in both directions. 15:56Accident in WolstantonA527 High Street partially blocked, slow traffic due to accident at B5368 Silverdale Road. (Image: Inrix)15:26Haslington councillor John Hammond diesHe had served on the council since 2008. More here.Councillor John Hammond represented Haslington at Cheshire East Council (Image: Cheshire East Council)12:46One lane closed due to broken down vehicle on M6 Southbound between J15 A500 (Stoke-On-Trent) and J14 A5013 (Stafford North). In the roadworks area. Lane two (of three) is closed. 12:44 (Image: Staffordshire Police)Detectives are hunting for the owner of a rare antique knife after it was stolen from a Staffordshire town over the weekend.The antique carving knife was found in the North Walls area of Stafford at around 2pm on Saturday afternoon (November 10) and officers are keen to reunite it with its owners.Staffordshire Police believe the knife could have been taken from its original owner due to its rarity.Read more.12:07 One lane blocked and heavy traffic due to broken down car on M6 Northbound from J18 A54 Middlewich Road (Middlewich / Holmes Chapel) to J19 A556 Chester Road (Knutsford). In the roadworks area. Lane one (of three) is blocked.11:24Heavy traffic on Brownhills Road / Davenport Street / Newcastle Street between A500 (Porthill Bank) and Tunstall. 11:11Queuing traffic due to the problems on the M6 on A534 Old Mill Road Northbound from B5079 / Crewe Road (Wheelock Roundabout) to M6 J17 (Sandbach / Crewe).10:57Slow traffic on A52 Werrington Road Westbound before A52 Leek Road (Lime Kiln Traffic Lights). 10:5410:54One lane closed and queueing traffic due to broken down car on M6 Northbound from J16 A500 (Stoke-On-Trent / Crewe) to J17 A534 Old Mill Road (Sandbach / Crewe). In the roadworks area. Lane two (of three) is closed. Breakdown has occurred within the residual delays on an earlier accident.10:37 A500 Northbound exit slip road partially blocked, slow traffic due to accident at M6 J16 (Stoke-On-Trent / Crewe). Lane one (of two) closed. Around Stoke-on-Trent.10:28A motorcyclist suffered suspected life changing injuries following a collision involving a car this morning.Police officers reported a collision between a bike and a car on Within Lane, Stafford , at around 9am today (November 12).The Staffordshire and West Midlands Serious Collision Investigation Unit had asked people to avoid the area as the road had to be closed off.Read more.10:22A34 Newcastle Road busy but moving between Springfield Retail Park and A500 D Road (Hanford Interchange). 10:08All M6 lanes are now reopen.The vehicles have now been moved into the Smart Motorway roadworks and all lanes reopened. There are delays of around 4.5 milies.09:53M6 lane reopenOne lane is now reopen following a collision on the M6.09:42Updates: Traffic held on M6 due to two-vehicle collision (Image: Highways England)Traffic has been held on the M6 in Cheshire because of a collision between a HGV and a car.The nortbound carriageway between junction 16, Crewe, and junction 17, Sandbach, was closed off shortly after 9.30am today (November 12).North West Motorway Police and Highways England are currently on the scene.Read more09:2909:24 A527 Porthill Road busy but moving at A500 D Road / Longbridge Hayes Road / Longbridge Hayes Road (Porthill Bank). 09:23Delays likely as THIS wide-load travels through the region today (Image: Staffs Police TST)Motorists have been told they face delays this morning as a 405ton, 69m long electrical transformer travels through Staffordshire and Cheshire.The transformer will be leaving GE, Lichfield Road, Stafford, at 9.30am today and will travel along Weston Road towards Beaconside, Redhill, and the A34 towards Stone and then Newcastle.It will then travel towards Talke where Staffordshire Police will hand over to colleagues in Cheshire at around midday today.The slow moving transformer will stop at Browns Bank, Congleton, around 90 minutes later.Read more.09:00Weather updates08:50 Traffic returned to normal on M6 Northbound from J18 A54 Middlewich Road (Middlewich / Holmes Chapel) to J19 A556 Chester Road (Knutsford). 08:19 Advance Warning – Abnormal load travelling from A34 Red Bull traffic lights. The load will continue through Congleton until it reaches Browns Bank on the A54. From 9:30 until 11:00 on 12th November. 08:12 Queuing traffic on A527 Biddulph Road coming from Brindley Ford Southbound at A5272 High Lane roundabout. Travel time is five minutes. 08:11 Slow traffic on A34 Newcastle Road between Springfield Retail Park and A500 D Road (Hanford Interchange). Travel time is four minutes. The video will start in 1Cancel Play nowlast_img read more

Read More

Virtuosos 2017 Incubator lineup includes Travelweeks Explor VR

first_imgTags: Virtual Reality, Virtuoso, Xplr VR Monday, April 24, 2017 Posted by David Thompson NEW YORK — Explor VR has been handpicked by Virtuoso to take part in the luxury retail organization’s Virtuoso Incubator tech start-up program, one of five companies chosen for the 2017 lineup. Explor VR is Travelweek’s virtual reality platform that launched nation-wide last fall, with free Explor VR headsets going out to travel agencies across Canada.Virtuoso Incubator is aimed at fostering technology that improves the travel advising process and overall client experience. It’s the industry’s first formal program focused on nurturing new technology solutions specifically for travel advisors. Incubator companies receive real-world input from Virtuoso advisors who test the product and suggest improvements so it will better serve the needs of travel agencies, consultants and clients.Each company receives a dedicated panel composed of Virtuoso advisors. More than 60 of them are volunteering in this capacity, with a member of Virtuoso’s Technology Committee acting as each panel’s liaison to the Incubator program. The Technology Committee also assists with vetting applicants and approving the companies that are offered Virtuoso preferred partner status.“Virtuoso Incubator was founded to fill a void in the travel advising industry,” said David Kolner, Senior VP, Global Member Partnerships at Virtuoso. “Our objective was to seek out business solutions for our travel agency members and create a real-life use case scenario for companies that were developing the technology we needed. The value to these tech companies is tremendous because we’re giving them access to their future customers, who are also providing feedback in real time. What we’re getting in return is the opportunity to create customized technology options for agencies ranging from just a couple of people to hundreds.”More news:  Sunwing offers ultimate package deal ahead of YXU flights to SNU, PUJThis year’s five Virtuoso Incubator participants are:Explor VR:  Travelweek’s app-based virtual reality platform tailored for the travel industry. It guides users on an immersive, emotionally engaging journey through a destination, leading to dramatically increased sales conversion rates and foot traffic. In addition, it educates advisors on destinations.Approach Guides: Its Trip Reads destination content service – featuring inspirational and thought-provoking videos, articles, books and podcasts – highlights cultural aspects of places around the world.TravelContact (formerly Alanna): A CRM technology that includes a client and provider database, email and newsletter marketing platform, smart multichannel communication, beginning-to-end trip builder, interactive client portal and a smart dashboard where advisors can see daily tasks.Tagible: Software that extracts keywords, making the words interactive and overlaying curated content such as YouTube, Google Maps and Pinterest. Drives engagement and increase conversion rate and time on site by keeping visitors on the agency’s website.tripFiles: A free private social network where travelers can store all their videos and photos at no charge, safely share trips, and never need to email/text photos to their travel companions.More news:  Sunwing to further boost Mazatlán service with new flights from OttawaVirtuoso Incubator also has a new partnership with Phocuswright, the global travel market research company. Phocuswright is referring innovative travel technology startups to the program, and sharing its research into the sector with Virtuoso as well as attendees at its exclusive network events.For more information see virtuoso.com/incubator.center_img Virtuoso’s 2017 Incubator lineup includes Travelweek’s Explor VR About Latest Posts David Thompson Latest posts by David Thompson (see all) Virtuoso’s 2017 Incubator lineup includes Travelweek’s Explor VR – April 24, 2017 << Previous PostNext Post >>last_img read more

Read More

Celestyal slashes summer cruise fares to Havana by 50

first_imgCelestyal slashes summer cruise fares to Havana by 50% Tags: Celestyal Cruises Friday, June 9, 2017 Travelweek Group TORONTO — Celestyal Cruises is turning up the heat this summer season with a new all-inclusive seven-day cruise promotion to Cuba.The offer features 50% off the cruise-only fare on all summer sailings until and including Aug. 21, 2017. Furthermore, kids younger than 12 sail for free.With promos and savings applied, rates start at US$1,171 per adult (embarking in Havana), based on double occupancy and includes:Seven-day Cuba Cruise featuring two days in Havana, one day in Cienfuegos, one day in Santiago de Cuba, and one day in Montego Bay, JamaicaIntimate 960 passenger capacity with yacht-like experienceInteractive shore excursion program in all portsAll meals onboardUnlimited beverage package, including alcoholic and non-alcoholic beveragesOnboard entertainmentGratuities and port chargesRemaining applicable 2017 sailing dates include: Montego Bay-Montego Bay (June 16, 23 & 30; July 7, 14, 21 & 28; Aug. 4 & 11); and Havana-Havana (June 12, 19 & 26; July 3, 10, 17, 24 & 31; Aug. 7, 14 & 21).More news:  Beep, beep! Transat hits the streets with Cubamania truckThe 50% off cruise fare offer is valid on new bookings made by July 31 for select sailings through August 2017. Reservations are based on a first-come, first-serve basis.Celestyal Cruises is celebrating its fourth year of cruise operation in Cuba, with cruises embarking every Monday from Havana and every Friday from Montego Bay, Jamaica. Posted by << Previous PostNext Post >>last_img read more

Read More

South African public broadcaster the SABC has seal

first_imgSouth African public broadcaster the SABC has sealed a deal for TV rights to the national football team’s games.The deal between the SABC and the South African Football Association took over a year to negotiate and covers the games played by the senior team and the under 23 side.Separately, the SABC is inaugurating a Production and Content Advisory Board, which will advise the public broadcaster on local content provision as it seeks to roll out new channels as the country completes its digital switchover.last_img read more

Read More

Swisscoms pay TV arm Teleclub has secured the rig

first_imgSwisscom’s pay TV arm Teleclub has secured the rights to Champions League and Europa League football in Switzerland and will air public broadcaster SRG’s coverage of the World Cup in 4K UHD TV.Champions League and Europa League games will be shown on Teleclub from August 21 and every match from both competitions will be available to Swisscom viewers.Some matches will be aired unencrypted on the Teleclub Zoom channels, which will be the only Swiss channel to air the Champions League final.Swisscom is working closely with SRG to provide 4K UHD coverage of the World Cup, including HDR. Swisscom TV customers will be able to follow the tournament on SRG’s channels SRF, RTS and RSI.Swisscom will provide additional background information on fixtures before and during games, such as background reports, team line-ups, information on individual players and other tournament developments, on its EPG.“It’s as if you’re actually sat watching the game in the stadium. HDR creates an effect that is similar to the jump in quality from analogue TVs to HD TVs, particularly for football broadcasts,” said Dirk Wierzbitzki, head of products and marketing and a member of the group executive board of Swisscom.last_img read more

Read More

Several readers have asked why I use CDs in so man

first_imgSeveral readers have asked why I use CDs in so many examples. With good reason, they wondered if I was suggesting buying CDs, which made them question my wisdom and sanity. If anyone thinks that’s what I’m recommending, I must have been remiss in conveying my message. On that note, I’d like to make one thing clear: I am absolutely opposed to buying any CD denominated in US dollars. (And since we’re clearing things up, I should also mention again that I am wholly opposed to TIPS.) When I use CDs in examples, I am usually referring to a lost time when they paid around 6% – a time when retirees could sail along on CDs and top-rated bonds without much worry. Since the first TARP bill passed in 2008, we’re hard pressed to find a CD paying more than about 1.2%, which is 0.5% below the government-reported inflation rate. It’s also 6.8% below the Money Forever Reader Poll Inflation Rate. Declining interest rates have hit retirees’ investment income hard; for many folks it’s dropped 50-80% from just a few years ago. So why would anyone want to make a long-term investment that is not keeping up with inflation and likely won’t catch up anytime soon? I certainly wouldn’t, and I strongly urge all readers to find other places to put their hard-earned money. Here is the bottom line: Before the 2008 crash, retirees could earn a decent yield on relatively safe investments. For many, this investment income was three to five times more than their Social Security checks, which allowed for a comfortable retirement low on financial stress. Now those same secure investments might bring in income equal to about half of your Social Security check. Before my wife Jo and I were married, we made one of our wisest investments: pre-marriage counseling. We had both been married before, and we wanted to make sure this marriage would be our last. One of our counseling assignments was to write down what we each wanted to be doing in 10 and 20 years. Our counselor also asked us to describe what “enjoying our golden years” meant to us. We took our assignments seriously, and as luck would have it, our dreams meshed quite well. We still consider ourselves truly blessed 25 years later. Some of the things we wanted were no-brainers. We wanted good health and enough money to not have to worry about it. While jetting around the world would be nice, our needs for happiness were much simpler. She grew up on a farm and my dad delivered mail; cool stuff is a bonus but not mandatory. We also wanted companionship to enjoy many things together and freedom to enjoy a few things apart. You get the point; we wanted the same things most ordinary people want. Nevertheless, having enough money to not have to worry about it turned into a trickier challenge than we’d expected. I retired at age 62. For the first six years, it was a dream. We lived in a motor home for a year and traveled extensively, nary a care in the world. Quite frankly, Jo and I were having a blast! That changed overnight, when the banks called in our high-yield, secure CDs. As I received more and more questions from readers about why I write about CDs so often, the more I realized what they had represented to us: freedom. Today we have enough money, but most of our capital is in riskier investments than FDIC-insured CDs. What investment could be more worry-free than a government-insured CD paying three times the rate of inflation? Moreover, it wasn’t just the yield that made us comfortable; safety was also key. If our government collapsed it was all over anyway, at least that was our thinking. The only folks I know who still have that same level of emotional comfort are retired federal employees. I can report that I now sleep much better than I did in 2008. However, it is still a far cry from our carefree joyride when I first retired. I know Jo and I are not alone. The Employee Benefit Research Institute (EBRI) does an annual survey on retirement confidence. Its 2012 survey reports that in 2005, 40% of retirees felt “very comfortable” that they had enough money to live on throughout their retirement years. Forty percent reported they were “somewhat comfortable.” In 2012 those numbers changed to 21% and 42% respectively. Also, in 2005, 7% reported they were “not at all” comfortable; that figure jumped to 19% in 2012. Here are some other interesting tidbits from that report: Americans’ retirement confidence has plateaued at the lowest levels seen over the last two decades. With her marriage, she got a new name … and a dress.  A will is a … dead giveaway. And my favorite: Police were called to a daycare where a three-year-old was … resisting a rest. Until next week… Twenty-five percent of those currently working say the age at which they expected to retire changed in the last year. In 1991, 11% of workers said they expected to retire after age 65, and by 2012 that grew to 37%. Baby boomers are now retiring at a rate of 10,000 per day and will continue to do so for the next 19 years. For decades, through economic ups and downs, they formed their retirement expectations. Now, in a few short years those expectations have been drastically altered.Back to the Future Thanks to the reader feedback I mentioned earlier, I have come to another conclusion: baby boomers on either side of the retirement cusp understand the problem, but they don’t all know what to do about it. Retirees have to make a detour; a bridge is out, and it won’t be repaired anytime soon. I can talk about 6% CDs all day long, but the truth is, they no longer exist. How can we achieve our retirement dreams in the current environment? Our retirement goals have not changed. We still want enough money to not have to worry about it. How we go about getting there, however, has been changed dramatically. So let’s focus on the task at hand. Personally, I advocate a three-pronged approach. First, we have little choice but to put a whole lot more of our nest egg at risk. We need to beat our current, high rate of inflation and earn enough to adequately supplement our Social Security checks. This means continuing to learn about and monitor our investments much more than we had to in the past. We have to diversify our investments to minimize the overall risk to our portfolios, and look into alternative investments and strategies. An uneducated or passive investor is setting himself and his family up for disaster. Second – and this is the part no one likes – we have to modify our lifestyles. That means different things for different people, but no matter how much money you have, we all have to live within our means. That’s just good, old-fashioned common sense. I’ve noticed that folks who accept the reality of our economic problems have an easier time making adjustments. They made sensible cutbacks early on and are damn happy they did. On the other hand, our friends who thought we were in an 18-month recession are hitting some real rough patches. Third and finally, we need to redefine “don’t have to worry about it” to fit today. When Jo and I were traveling the country in our motorhome, Internet connections were spottier than they are today. We would check into a campground and ask if they had an Internet hookup. If they did, we would check our email and update our brokerage account. If not, no big deal; hopefully we would find one at the next campground. That was the epitome of not worrying about it. Not worrying looks a lot different today. We know and understand where our money is invested, and we continue to learn every day. While I would use the word “comfortable” to describe our situation, it’s still a far cry from our carefree, passive attitude of yesteryear. That was a dream… and a whole lot of fun while it lasted. Nevertheless, an educated, confident investor can still sleep very well. If you’re up counting sheep and worrying about your portfolio, skip the Ambien. Instead, I invite you to learn about Miller’s Money Forever and take advantage of our no-risk, premium subscription. If you decide it’s not for you, just call or email within the first 90-days and receive a 100% refund. And if you do decide to stick with Miller’s Money Forever, it’s still less expensive than a lifelong Ambien prescription. As the EBRI survey pointed out, in 2005 40% of those surveyed said they were “very comfortable.” By 2012 the number had dropped to 21%. Our goal at Miller’s Money Forever is to make sure our subscribers all fall into the 21% who are “very comfortable.”On the Lighter Side I saw that Danica Patrick won the pole position for the Daytona 500. I suspect that will add a few million viewers to the race next week. While she was born in Beloit, Wisconsin, she grew up in Roscoe, Illinois, right across the state line. We have friends who lived there, and she is certainly a hometown hero. Our Florida weather has been a bit cool over the last few days; the forecast for the race day is in the low 70s. Let’s hope it’s a good and safe race. —- My friend Rob – of We Buy Gold fame – and I went to a coin show over the weekend. There was no junk silver to be found, and Silver Eagles were also in short supply. After speaking with several dealers, they felt the current downturn in the price of metals will be short lived. And finally… Our friends Ed and Sarah sent us some clever puns. When the smog lifts in Los Angeles … U.C.L.A.  The batteries were given out … free of charge.  A dentist and a manicurist married … They fought tooth and nail. The percentage of workers expecting to retire before age 65 has decreased from 50% in 1991 to 24% in 2012.last_img read more

Read More

Saudi Arabia

first_img Saudi Arabia The United States has the largest refining capacity in the world and is still by far the largest consumer of oil in the world (though China is beginning to catch up), and its refineries require 15 million barrels of oil a day. That means even though, due to the shale revolution, domestic production has dramatically increased to about 8 million barrels, the US still has to import between 7 and 8 million barrels of expensive foreign oil a day. Let’s take a look at who the US buys the imported oil from. (Now that I finally figured out my way around the new Windows 8—which, by the way, really sucks—I can even add some color to my tables.) Canada 2.5–3 Millions of barrels exported to US per day Top 10 Things You Didn’t Know Use Compounds Made from Crude Oil Golf balls Toothpaste Soap Aspirin Life jackets Louis Vuitton knock-offs Guitar strings Shoes Soccer balls Pantyhose 0.8 0.8–1.0 Venezuela Mexico But really, I’ve had a pretty good run. Here is my audited return since January 1, 2012 (green column on the left). 1.2–1.5 While the White House spied on Frau Merkel and Obamacare developed into a slow-moving train wreck, while Syria was saved from all-out war by the Russian bell and the Republicrats fought bitterly about the debt ceiling… something monumental happened that went unnoticed by most of the globe. The US quietly surpassed Saudi Arabia as the biggest oil producer in the world. You read that correctly: “The jump in output from shale plays has led to the second biggest oil boom in history,” stated Reuters on October 15. “U.S. output, which includes natural gas liquids and biofuels, has swelled 3.2 million barrels per day (bpd) since 2009, the fastest expansion in production over a four-year period since a surge in Saudi Arabia’s output from 1970-1974.” After the initial moment of awe, pragmatic readers will surely wonder: Then why isn’t gasoline dirt-cheap in the US? There’s indeed a good explanation why most Americans don’t drive up to the gas pump whistling a happy tune (and it has nothing to do with evil speculators). Let’s start with the demand side of this equation. Crude oil consists of very long chains of carbon atoms. The refineries take the crude and essentially “crack” those long chains of carbon atoms into shorter chains of carbon atoms to make various petroleum products. Some of the products that are made from petroleum may surprise you. Good day in the markets Bad day in the markets 0.3–0.5 Country Kuwait Canada is blue because it is not only friendly with the US, but also has the ability to increase oil production. The other countries are red because they either have decreasing oil production, or the country is not on good terms with the US government, or the production may be at risk for various reasons. The “red countries” all sell oil to the US at higher prices than does Canada. As I said, the US imports about 7 million barrels of oil a day, and our top 5 exporters make up between 5.6 and 6.8 million barrels while the rest is split among other countries. This means that even though the US has significantly increased its oil production in the past five years, a good chunk of oil has to be imported at much higher prices. And higher crude oil prices for refineries means higher prices at the gas pump. But that’s not the only issue: The “new oil” produced from the shale oil fields in the Bakken and Eagle Ford formations isn’t cheap. Both the Bakken and Eagle Ford have been hugely successful, and an average well in either region can produce over 400 barrels of oil per day. That may sound like a lot, but drilling thousands of meters into the ground (both vertically and horizontally), then casing and fracking the well, costs millions of dollars. And the trouble doesn’t end once the well has been drilled: oil and gas production can drop as much as 50% in the first year. Think of it as running on a treadmill—but the incline gets steeper and steeper the longer you run. That’s the current reality of America’s oil production. Now, these areas also have to deal with declining legacy oil production (“legacy” meaning older oil wells that produced before fracking became popular) due to depletion rates. Freeze-offs, and even hurricane season can affect the legacy oil wells’ production decline. As the old wells begin to deplete, they need to be replaced by unconventional wells with horizontal drilling and hydraulic fracturing. Even though these new wells provide an initial burst of production, they decline very quickly. That means you need to drill even more wells just to keep up—and the vicious cycle continues. The costs, as you can imagine, are forbiddingly high. Even in known oil-rich regions like the Bakken and Eagle Ford, the all-in cost of extracting a barrel of oil from the ground can cost as much as US$75 per barrel (for comparison, Saudi Arabia can produce oil for as low as US$1 per barrel). To put it in simple terms: cheap oil in North America is a thing of the past. So, the US produces expensive oil and relies on imports of even more expensive oil. And since the refiners need to make money as well, this means higher prices at the pumps. Who loses? The US consumer, of course. What would help lower gas prices? Building more pipelines to deliver cheaper Canadian oil to refineries in the US and decreasing the refineries’ dependence on expensive foreign oil. Until these new and much safer pipelines are built, rail has to pick up the slack. Almost 400,000 railcars full of oil are expected to be shipped in 2013, compared with just 9,500 railcars in 2008, a whopping 41-fold increase. But rail is not the answer. In fact, transporting oil by rail is much more dangerous than transporting it by pipeline. Just last week, we wrote about two recent accidents, one of which claimed 47 lives. Federal and state taxes at every step of the gasoline-making progress make the pain at the pump even worse. The US government already takes more than 60% of the divisible income from every barrel of oil produced… and another 50 cents per gallon at the pump. Then there’s the matter of Obama’s supposed “Green Revolution” and how America would be saved through the use of alternative energies. Obama wrote massive checks to different renewable energy firms that went belly-up, the most famous of them all being solar panel manufacturer Solyndra, whose bankruptcy cost American taxpayers more than $500 million. Obama is also a heavy supporter of ethanol (his home state of Illinois, after all, is the third-largest ethanol-producing state) and has increased the targets for the use of ethanol in transportation. Someone has to pay for all of these subsidies, so why not get the dirty, evil oil companies to pay for them? Keep in mind, though, that the oil companies have enough lobbyists and lawyers to keep the government at bay—so the higher prices will be passed on to the consumers. To sum up why the price of gasoline is so high even though the US is producing so much more oil than before: The high cost of American oil production Even higher costs due to imported (non-Canadian) oil Obama not allowing cheaper Canadian oil to flow to the refineries via pipelines such as the Keystone XL The taxes on crude are used to fund Obama’s green dream—his green-energy “legacy”—and his love for ethanol and the taxes at the pump will not decrease So what does this mean for you, the consumer? You have two options: You can gripe about high gas prices… or you can choose to profit from the situation, no matter how dire. If you’re the former type, so long, and I hope you enjoyed my missive today. If you’re the latter, let’s talk money. Who am I? Well, I kinda look like this guy… I stand by my performance and offer anyone reading this article a guarantee: if you try the Casey Energy Report today and do not think that it’s the absolute best energy newsletter in the business, you get all your money back, no questions asked. I’m not saying I’m perfect (my wife reminds me daily that I’m not ), but I’m willing to put myself out there and offer you a challenge to expand your knowledge and become a better investor. All of my past newsletters, going back to 2006, are up on the Casey website, and I want you to check them out. I have lost money on investments (anyone who says they haven’t is a liar), but I made sure I learned something from every harsh experience. And overall, I’ve made much more than I’ve lost. Our energy portfolio has been delivering +50% gains since January 1, 2012. Right now, I’m the first to publish on what I think is going to send my track record to the moon. I’m on to an investment theme that I believe has the potential to make 10-fold returns for investors who play it right. That theme is the European Energy Renaissance. Doug Casey and I are convinced that new technologies applied in the Old World will bring huge New World profits. But don’t take my word for it—I challenge you to try out my research. Click here to take me up on my 100% money-back guarantee. Additional Links and Reads OPEC Warning of $150 Oil Price If Member Countries Cut Investment (The National) What people often forget about the oil and gas sector is that it is a very capital-intensive business. If companies (or countries) do not consistently re-invest in their production, the amount that comes out of the fields inevitably drops lower and lower. To make matters worse, the demand for oil within petroleum-exporting countries is increasing due to population growth. This means much less will be available for exports, leading to higher oil prices worldwide. Pirates Abduct Two Americans on Oil Ship Off Nigeria Coast (New York Times) Piracy is still a very real concern worldwide when it comes to shipping, adding yet another layer of risk in the global oil and gas trade. Though the phenomenon has died down somewhat in Somalia, we see that piracy is still alive and well in other parts of the world. In the latest event, two American citizens have been abducted in Nigeria. This could be the beginning of a worrying trend of increased piracy around parts of Africa. Final Keystone Review Assesses Potential of Oil-by-Rail Transport (Globe and Mail) US officials are currently considering whether transporting oil by rail is a viable alternative to the pipeline. However, as we have mentioned in previous issues of the CDD, they will soon find that despite the fact that it’s theoretically possible to ship the oil by rail, it will be much more expensive and much less safe. If it comes down to a clash of the lobbyists, however, who knows what could happen?last_img read more

Read More

In This Issue   Markets think the elections ar

first_imgIn This Issue. *  Markets think the elections are good for the U.S. *  Gold loses $28 and probably more as the day goes on! *  Canada gets a renminbi hub! *  U.S. Trade Deficit soars to $43 Billion! And Now. Today’s A Pfennig For Your Thoughts. Currencies & Metals Get Ambushed! Good Day!…  And a Wonderful Wednesday to you! Right from the top this morning (and before I have a senior moment) I want to say a GREAT BIG HAPPY BIRTHDAY to the lovely Rachel Butler. Oldest son, Andrew’s lovely bride, Rachel. I always think of the first time I met Rachel, it was at the Annual Butler Christmas Party, and I thought, she’s perfect for Andrew! And so it was, a few years later, they were married! Now, she’s a Butler, and a big part of our family. Happy Birthday, sunshine. Well, there’s no sunshine for the currencies and metals this morning, and guess what’s getting blamed for this ambush this morning. The results of the mid-term elections in the U.S. last night, which saw the Republicans gain the Senate for the first time in long time, and the markets are all giddy about this prospect.  It seems they think that this will grease the tracks for clearer decision-making to take place. Hey! I didn’t say that, the pundits out there in writer-land did! I’m just reporting what they are associating the ambush on the currencies and metals this morning with. Of course, I could very easily say to them, if they would hear me now and listen to me later, that this is no panacea for debt cutting, and budget balancing. For, when this dollar weak trend began we had the same scenario, expect the President was from the other party. Remember that? So, I guess what I’m saying is that there’s no guarantee that business will recover because of the party in charge. And that’s all I’m saying about this political stuff, because it gets me nowhere, I’ll tick off half the readers, and make the other half not so happy because I didn’t jump up and down in an euphoric dance!  But, the damage to the currencies and metals this morning is UGLY. They aren’t just getting hit with the UGLY stick, they are having the whole forest hit them! Gold is down $26 this morning, and looking like it could go even lower. Last night I was reading a report from Casey Research, and the headline of the story read: Sellers Waterboard Gold – Is The Price Torture Over?  Well, the markets are answering them this morning, and saying not no, but Hell No! I saw another conspiracy thought yesterday regarding who’s behind this latest drive to get Gold cheaper. The thought centered around the Swiss Gold Referendum. Saying that the Swiss are behind this move to get Gold cheaper, for they believe they will lose the resistance to the Referendum, thus requiring them to buy 1,700 tonnes of Gold, as I explained last week. Well, if they have to start buying, wouldn’t it be better to start at a cheaper price? Of course it would be. But let me ask this question, and don’t get me wrong, the idea is solid, just not the player. Do they really think the Swiss National Bank (SNB)  have enough intestinal fortitude to do this? I don’t.  But then they did pull of that devaluation of the franc two years ago, and the markets barely batted an eye. Well, this is no fun. watching Gold get ambushed day after day by the paper trades. As I told you yesterday, Koos Jansen reported that China has an insatiable demand for physical Gold, and Russia, and Turkey, and Brazil, I could go on, but just about every county in the East and Middle East are adding to their Gold reserves. Are they doing this for the hell-of-it? Or, are they doing so, because they see something coming down the pike that’s going to be UGLY. Even uglier than this ambush of the currencies and metals this morning by the dollar bugs. But you know. I told you months ago that I thought the dollar was ready to have a short period of strength, and could drive the euro down to below 1.20. I just didn’t think it would come this quickly, which leads me to believe that we could very well see a bounce that’s based on the drop in the currencies was too far, too fast. We usually see that. I’m just saying. OK. on Monday I told you the Big News regarding the direct convertibility of the Chinese renminbi, with Singapore dollars. Well, it was Big News as far as I’m concerned, and let me remind you that in 2008, I began writing about the currency swap agreements that China was signing with one country at a time, and thought that too was Big News, even if most news outlets didn’t see it that way.   And then yesterday, in the Canadian National Post, was more Big News. Apparently, this coming weekend, when Canadian PM Stephen Harper visits China, both he and the Chinese will use the visit as an opportunity to announce that Canada (Toronto) will become a trading hub for the renminbi, thus allowing Canadian firms to trade directly in the local Chinese currency, rather than converting loonies in U.S. dollars to do business in China.   This is the culmination of the currency swap agreement that was signed last year between the two countries, where they agreed to swap each country’s currency, thus leaving out the U.S. dollar, in the terms of trade between the two countries.  Now there is a Hub in Canada, for depositing renminbi, by Canadian firms doing business in China. It just keeps growing bigger and bigger all the time folks. The Chinese drive to gain a wider distribution of the renminbi, which is the number one requirement of a reserve currency! I don’t know of any other way I can emphasize the importance of the news regarding the renminbi this week. I can no longer do handstands or cartwheels (I was a on the “tumbling team” as a young man in elementary school, yes, I know, look at me now, go ahead and laugh, that’s OK, I know that somewhere in this extra-large body is the Chuck that was quite, what my dad used to call, a country athlete)  But I digress.   What I’m saying is this is absolutely crazy that no news outlets are of the same mind as me and believe this news is important. UGH! I told you yesterday that the Reserve Bank of Australia (RBA) left rates unchanged, and didn’t take their meeting as an opportunity to deep six the Aussie $ (A$). But today, the A$ has lost over 1-full cent. Why? Wasn’t the fall from $1.04 to the low 90-cent range, tied to the weak prices in commodities, namely iron ore? And then the fall from the low 90-cent range to 88-cents due to RBA jawboning the currency lower? And then what’s to blame for this next downward move?  I really think the interest rate differential narrowing talk in favor of the U.S. dollar is getting overblown. But it is what it is, right? We have to deal with it. until someone has a V-8 head slap moment, and realize they have been premature with their thoughts about rates in the U.S.. That could take some time, folks, for these knuckleheads have very thick skulls! Or, it could last until the next round of QE is announced. Yes, I know that’s not carved in stone, and it might never happen, but as I said the other day, if it doesn’t ever happen, then I’ll believe that pigs can fly.  So, I guess it would be good to talk about when I suspect the next round will come. They were discussing the timing of the next round of QE (QE4) in the 5 Minute Forecast / The “5” last Thursday, and they said that James Rickards pointed out that” the time between the end of QE1 and the start of QE2 was 17 months. The time between the end of QE2 and the start of QE3 was 15 months. So, expect QE4 in late 2015″.  And I thought, no, no, no, that can’t be, I see the lack of liquidity and the drop in inflation happening far before that. And then The “5” went on to say that they have this “Oh Sh*t” Graph, that tracks inflation. And funny thing, every time, since 2009, that inflation dropped below 2.2%, the Fed has embarked on another round of QE, and guess what the graph is telling us now?  “Uh-Oh, the line has been breached!  Inflation has dropped below 2.2% again. Come again, I hear you saying. Are you telling me that we could expect QE4 at any time now? Ahhh, grasshopper, not quite yet. the Fed will have to see that all their hard word of the past 6 years is being undone for sure first.   Because consumer inflation can be volatile, but we should continue to look for this to happen. And when it does, all this talk of dollar strength will be reversed, or at least that’s how I see it, it’s my opinion and I could be wrong! Well, the U.S. Trade Deficit widened by an amount that was not seen or forecast by the experts in September, and guess what the culprit was? Well, first let’s talk about the size of the Trade Deficit, which printed at $43 Billion in September, up from $40 Billion in August.  The deterioration came from exports falling 1.5% and imports remaining unchanged.  So, guess what the culprit was?  The relatively stronger dollar.  Just another unintended consequence of a strengthening currency on a country that depends so much on exports to offset the imports that are usually quite high.  Of course, exports could have been held down too, by the slowing economies of the world. But, these countries still need capital goods, no matter how slow their economies are, just like here in the U.S. we import things like Oil no matter how slow the economy is. The U.S. Data Cupboard was busy yesterday with the Trade Deficit print, and the ugly -.6% negative print of Factory Orders, which wasn’t as bad as August’s -10% print, but ugly nonetheless.  The NY regional ISM (manufacturing index) fell from 63.7 to 54.8. That’s a HUGE drop, but these regional reports can be volatile, and I grew tired of reporting on them because they never seemed to have any bearing whatsoever on the National ISM, but this one stuck out like a man with a hatchet in his forehead! Today’s Data Cupboard will begin to get us ready for the Jobs Jamboree on Friday, when the ADP Employment Change report for Rocktober. This report is expected to show that 220,000 jobs were added in Rocktober.  The song: The Walker, by Fitz and the Tantrums is playing, and I have the speakers turned up so loud, it’s a good thing I’m here by myself! This is a real  wiggle and bounce in your chair song!  I had a laugh the other day, when the National ISM report and the Markit version of ISM printed for Rocktober.  One showed a HUGE gain in the index up to 59, and the other showed a lower number of 55. Now remember this printed on Monday before the elections yesterday, so guess which one the Gov’t is responsible for printing and which one is a public company. Are you laughing out loud with me on this? That gain to 59 was so trumped up that it made it look ridiculous! The size of the, no wait I can’t say that. I’ll just say that the boys and girls printing that number were brave, eh? I read a story on the Bloomberg this morning that pretty much sums up the data prints in the U.S..  Let’s see what the Bloomie has to say.. “Paul Singer’s Elliott Management Corp. said optimism on U.S. growth is misguided as economic data understate inflation and overstate growth, and central bank policies of the past six years aren’t sustainable. Nobody can predict how long governments can get away with fake growth, fake money, fake jobs, fake financial stability, fake inflation numbers and fake income growth,” New York-based Elliott wrote. “When confidence is lost, that loss can be severe, sudden and simultaneous across a number of markets and sectors.” Amen brother! I think this is bang on, folks. and I’m glad I happened to see it, as I was looking through stuff on the Bloomie this morning. My email box was loaded with emails from the WSJ and Washington Post this morning, giving me the results of the all the races, as if I really wanted to see all those! UGH!, so I spent part of the morning, deleting over 100 emails!  Gold isn’t the only metal getting ambushed this morning by the dollar. Silver has a $15 handle, Platinum has lost $25, and Palladium has lost $42 since yesterday morning. OMG! (oh my goodness!) This is crazy folks, just downright crazy! For What It’s Worth. There’s something happening here, what it is, ain’t exactly clear.  Yes, I’ve waited a long time to use that line after the FWIW beginning. and today’s piece works out perfectly, for we have some numbers, but it’s just not clear what to make of them yet.  I saw the headline on Ed Steer’s letter, and so I went to the site at Newsmax.com to find the story. Are you ready? Yes, I’m ready. “The portion of home purchasers who are first time buyers dropped to 33 percent for the 12 months through June, the lowest since 1987, and down from 38 percent a year earlier, according to a survey by the National Association of Realtors. The average since 1981 is 40 percent. “Rising rents and repaying student loan debt makes saving for a down payment more difficult, especially for young adults who’ve experienced limited job prospects and flat wage growth since entering the workforce,” Lawrence Yun, the NAR’s chief economist, said in a statement. Average hourly wages for all workers rose only 2 percent in the 12 months through September. “Adding more bumps in the road is that those finally in a position to buy have had to overcome low inventory levels in their price range, competition from investors, tight credit conditions and high mortgage insurance premiums,” Yun said.” Chuck again. Chris and I were talking about housing and housing loans yesterday, and in the previous day, we discussed with one of our mortgage guys in Jacksonville, who told us that there is more pressure on banks to give loans to low credit rating borrowers. Chris and I said, isn’t that what got us in this crazy financial meltdown to begin with?  And then Mike Meyer chimed in and said, ” Yes, and when it all crashes like it did before, who are they going to blame? The Banks for giving the low credit borrowers loans!”  I shake my head in disgust that this is happening again. To recap. The currencies and metals are getting ambushed by the dollar this morning, and it’s all due, according to the stories on the wires, to the Republicans winning the Senate which gives them the ability to set the course for the President’s last two years, and the markets believe this will be clear decision-making. Of course Chuck pointed out that we’ve seen this before, about 12 years ago at the beginning of the weak dollar trend. so, he’s questioning their thought process. (but isn’t Chuck always questioning the markets’ thought processes? HA!) Gold is down $28 as I write, and looks like it could be one of those really ugly days for the shiny metal. Canada will have a hub for renminbi to facilitate trade and allow the direct exchange of loonies and renminbi in the terms of trade. This is HUGE news folks, but don’t tell the news agencies, or the markets, they can’t seem to find their rear end with both hands. Currencies today 11/5/14. American Style: A$.8620, kiwi .7735, C$ .8740, euro 1.2480, sterling 1.5905, Swiss $1.0365,  . European Style: rand 11.1495, krone 6.8845, SEK 7.3840, forint 247.45, zloty 3.3940, koruna 22.2830, RUB 44.18, yen 114.70, sing 1.2955, HKD 7.7525, INR 61.41, China 6.1503, pesos 13.63, BRL 2.5200, Dollar Index 87.53, Oil $76.96, 10-year 2.35%, Silver $15.24, Platinum $1,200, Palladium $757.80, and Gold. $1,141.35 That’s it for today. Well, did you get out and vote? It was an ugly rainy day here, so getting out to vote took effort, but I did my part despite the weather. It’s difficult for me on days like this when everything that I believe about economics, markets, and trading is shattered, shaken, and left for dead. But about 7 years ago, after being told I had Stage 4 cancer, I began to have a different outlook about those things I couldn’t control. I have no control over the markets, or the people that make up numbers for economic reports, or created Trillions of dollars with one stroke on a keyboard, so I work diligently to not let these things get to me. Instead I attempt to focus on what’s important. like Rachel Butler’s birthday today! I understand that we’re going to dinner tonight to celebrate Rachel’s birthday, so that should be fun!  Shooting Star is playing their hit song: Last Chance, on the IPod, man that was a big song in the 80’s. They were a Kansas City, Mo band, so they got a lot of air time here in St. Louis.  See, there, a little rock history on top of all the other things we talked about today, where else can you get such a wide array of information in one place. Like the Wide World of Sports. Spanning the Globe. And then the sky jumper falls off the ramp.   Good and bad. just like the everything else. But the good today is that it is Rachel’s Birthday! YAHOO!  And. our catcher, Yadier Molina won his seventh consecutive Gold Glove! WOW!  Ok. time to get out of your hair today. that is if you have any left after seeing the ambush. I hope you have a Wonderful Wednesday! Chuck Butler President EverBank World Marketslast_img read more

Read More

Download Entrepreneur Magazines App for Apple and Android

first_imgEntrepreneur Corporate Communications Download Entrepreneur Magazine’s App for Apple and Android 3 min read Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business –shares Image credit: Entrepreneur Access the latest issues of Entrepreneur and enjoy the latest news, videos and how-to articles-in one place, on any of your Apple or Android devices, and on your own terms. Entrepreneur Media Corporate Communications Here at Entrepreneur, we are always seeking ways to make it easier for you to get the information you need to boost your business productivity. We know you’re busy—and reading and viewing the latest business advice, trends and tips should be a bright spot in your day.To improve your Entrepreneur experience, we are excited to announce the latest evolution of our mobile app. In one seamless experience, you’ll find an ongoing stream of the latest news, how-to articles, exclusive interviews and videos from Entrepreneur.com. If you’re a magazine subscriber, you can access the newest issue of Entrepreneur magazine, plus your favorite archived issues, in a new mobile-optimized display that auto adjusts across your devices.Download the Entrepreneur magazine app on your iOS or Android device and enjoy:More Content: View the latest news and videos including trending articles, exclusive interviews, infographics, and more from Entrepreneur.com. Plus, access the latest issues of Entrepreneur magazine.Interactive Features: Now use 3D Touch, Interactive Push Notifications and Save for Later, which allows you to save content and read it later offline on your preferred device (syncs user content across multiple devices) for efficient, practical reading.Easy Read, Optimized Display : Enjoy the same fluid reading experience found right here on our website, no matter what you’re reading (our magazine articles are no longer bound to a fixed PDF layout) or what you’re reading on (the presentation will auto adjust to the device and screen orientation).In short, you can now effortlessly enjoy our magazine and digital content—in one place, on any of your Apple or Android devices, and on your own terms.How Does This Work?Our improved app will retain the Entrepreneur magazine name and we will be phasing out the Entrepreneur Daily app. Here’s how you get it:If you use the Entrepreneur Magazine app on iOS or Android: You don’t need to do anything. Depending on your settings, the app update will automatically update on your device or you may be required to activate the update. That’s it!If you use the Entrepreneur Daily app on IOS: You will need to download the new Entrepreneur magazine app. If you use the Entrepreneur Daily app on Android: You will need to download the new Entrepreneur magazine app. Note: While you will have still access to all our great digital-only content, the full digital magazine articles is only available to subscribers. You can easily upgrade within the app.Thank you for your past and continued readership. We look forward to bringing you the business productivity content you need in an easy-to-read format you’ll enjoy.Download the Entrepreneur magazine app on your iOS or Android device now. Add to Queue Register Now » May 26, 2017 Learn how to successfully navigate family business dynamics and build businesses that excel. Opinions expressed by Entrepreneur contributors are their own.last_img read more

Read More

What to Expect at Apple WWDC 2017

first_imgApple This story originally appeared on PCMag 2019 Entrepreneur 360 List June 5, 2017 The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue Apple’s annual Worldwide Developer Conference (WWDC) kicks off Monday in San Jose, where we expect to hear about the new versions of iOS and MacOS, and perhaps One More Thing.We’ll have hands-on coverage from the event floor that day, but for now, here are some of the most prominent rumors and likely announcements making the rounds in the lead up to the keynote.iOS 11 and MacOS 10.13The only true surefire bets for WWDC are new versions of Apple’s mobile and computer software platforms. Most Apple consumers will end up with some or all of the announced features depending on which products they use, and developers are eager to hear what they’ll have to work with, so these will be the stars of the show.Expect the usual updates to core apps like Safari and Mail, with productivity enhancements across the board. Exact feature additions will read more like a wish list since little is known or confirmed currently, but maybe we’ll see announcements like conference calls in FaceTime.Improvements for watchOS and tvOS should also be on display, mainly in the form of more integration into the two main platforms. Increased Siri functionality and unification across the platform might play a big part in the conference, too, especially if the next rumor turns out to be true.Siri speakerApple’s answer to Alexa (and more recently, Google Home) has been long expected, and it seems like this could be the year we finally see one.Whether this is something consumers are itching for remains to be seen — no doubt many interested in a voice assistant have given in and purchased an Amazon Echo or Google Home by now, but the Apple ecosystem could be enough of an incentive to buy. Either way, Bloomberg reports that a Siri speaker has already entered production, so there’s a good chance we see it on Monday.That said, Apple could wait to debut the speaker later in the year, which would be closer to its expected shipping date. If reports are true, it will differentiate itself from the Echo and Google Home with features like virtual surround and, as mentioned, integration with the already ubiquitous lineup of Apple products in millions of homes.MacBook and MacBook Pro refreshesThe standard MacBook and MacBook Pro lines were given some love in 2016 with modest redesigns and, in the case of the Pro, the introduction of the Touch Bar. As such, any announcements about these two lines at WWDC will likely include minor component updates, such as the latest generation Intel processors, rather than major physical or feature changes.There have been some industry rumblings to support this speculation, but it may turn out this traditionally software-focused event saves its MacBook overhaul for a product that might need it a little more attention.New MacBook Air?The Air remains an all-time favorite laptop for many, despite Apple’s relatively infrequent updates to the line. It’s appealing as the cheapest (comparatively) entry in Apple’s laptop line, and did not receive the 2016 refresh its counterparts did. An “if it ain’t broke, don’t fix it” approach makes some sense here, but the most recent MacBook Air was released in 2015, and if Apple skips another upgrade, 2018 is an awfully long wait in computer time.If it does arrive, expect a USB-C only approach, since even the “thicker” 2016 MacBook dropped the larger standard USB ports. The 1,440-by-900-display resolution would almost definitely receive a boost, since it was already on the low side in 2015, and its great battery life may very well creep even closer to 20 hours.Refined iPad ProIf the existing 9.7- and 12.9-inch iPad Pro models don’t do it for you, how does something in the middle sound? Thanks in part to analyst expectations (as reported by Mac Rumors), there’s plenty of buzz suggesting a 10.5-inch iPad Pro will be revealed at WWDC that similar in size to the 9.7-inch model.The extra screen space will be made possible by much thinner bezels — nearly edge-to-edge — so that Apple can fit a larger screen in a smaller body. In fact, it may replace the 9.7-inch version altogether, since it’s essentially the same size with a bigger display. Odds are this won’t be the only upgrade: The usual component updates like better cameras, a new processor, and maybe a new Apple Pencil would fill out the rest of this announcement. Apply Now » Matthew Buzzicenter_img Next Article Check out the most prominent rumors and speculation about WWDC ahead of Monday’s keynote. Writer Image credit: via PC Mag 4 min read What to Expect at Apple WWDC 2017 –shareslast_img read more

Read More

Facebook May Take Extra Steps to Remove AntiVaccine Misinformation

first_img Facebook is “exploring additional measures” to fight anti-vaccine disinformation, according to Bloomberg. Content discouraging parents from vaccinating their children has been rampant on the site, particularly in Facebook Groups, and may have contributed to a measles outbreak in Washington State. That caught the attention of U.S. Representative Adam Schiff, who wrote a letter to Facebook and Google asking them to address the problem.Schiff noted that Facebook is surfacing and recommending messages that may pose a threat to public health. For instance, the Guardian recently reported that Facebook was accepting and promoting ads from anti-vax groups. “Repetition of information, even if false, can often be mistaken for accuracy,” he wrote. “The algorithms which power these services are not designed to distinguish quality information from misinformation.”Facebook said that it’s “exploring additional measures to best combat the problem,” including “reducing or removing this type of content from recommendations, including ‘Groups You Should Join,’ and demoting it in search results, while also ensuring that higher quality and more authoritative information is available.”The resurgence of measles is of serious concern, with extended outbreaks occurring across regions, and particularly in countries that had achieved, or were close to achieving measles elimination.Google recently said YouTube would restrict video recommendations that “could misinform users in harmful ways,” including anti-vaccine videos. It also said recently that would provide links alongside videos on “historical and scientific topics that have often been subject to misinformation.” Until recently, anti-vax videos topped results for “vaccine” searches, but the top results now appear to be from sites like Last Week Tonight attempting to dispel vaccination myths. However, Robert F. Kennedy’s widely debunked anti-vax documentary is still in the top 10.The CDC notes that vaccines have been proven safe and effective and only result in minor side effects. However, avoiding them can put not just your own children but others at risk, particularly small babies who have yet to be inoculated. “Without urgent efforts to increase vaccination coverage … we risk losing decades of progress in protecting children and communities,” said Unicef’s Dr. Soumya Swaminathan. Add to Queue 2 min read Next Article Register Now » –shares Image credit: Fred Tanneau | Getty Images via engadget Facebook Steve Dent February 15, 2019 Facebook May Take Extra Steps to Remove Anti-Vaccine Misinformation Learn how to successfully navigate family business dynamics and build businesses that excel. This story originally appeared on Engadget Conspiracy theories on the site may have contributed to a measles outbreak. Free Webinar | July 31: Secrets to Running a Successful Family Businesslast_img read more

Read More

Consumer Reports Drops Its Tesla Recommendation

first_img Consumer Reports said it would no longer recommend Tesla’s Model S sedan due to reliability concerns, in a blow to the luxury electric-powered car initially awarded the highest-ever score in the U.S. magazine’s performance ratings.The decision, based on the influential publication’s annual survey of vehicle reliability, sent shares of Tesla Motors Inc reeling and underscored the risk of introducing cutting-edge fuel-saving technology and digital multimedia systems in vehicles.Consumer Reports found “an emerging trend of increased troubles” with a broad range of vehicles that use new transmission technology to boost mileage. The survey was presented by the magazine’s editors at a meeting of Detroit’s Automotive Press Association on Tuesday.The findings illustrate automakers’ challenges as consumers and regulators demand more innovation. Groundbreaking technology comes with a heightened risk of malfunctions over the life of a vehicle, compromising the reliability car owners enjoy from more mature technology.Tesla’s stock fell as much as 11.4 percent before closing down 6.6 percent to $213.03 after the magazine said Tesla owners reported “an array of detailed and complicated maladies” in their Model S sedans.Still, 97 percent of Tesla owners would buy another Model S, the magazine found, citing quick responsiveness on repairs from the Palo Alto-based company “with a minimum of fuss to owners.”One of the most technologically adventurous cars on the market, the Model S registered a worse than average reliability score based on survey responses from 1,400 owners.The battery-powered Model S P85D was lauded in August for racking up the best scores ever in the magazine’s performance tests. But owners complained of rattles, leaks, and problems with the charging equipment, drivetrain and center console displays, Consumer Reports said.”Close communication with our customers enables Tesla to receive input, proactively address issues, and quickly fix problems,” a Tesla spokesperson said. “Over-the-air software updates allow Tesla to diagnose and fix most bugs without the need to come in for service. In instances when hardware needs to be fixed, we strive to make it painless.”Complaints about balky multimedia infotainment systems continue to plague several major automakers, including Ford Motor Co, Nissan Motor Co, Fiat Chrysler Automobiles NV and General Motors Co, the magazine found.Honda Motor Co’s Acura luxury brand fell seven places to No. 18 in the magazine’s ranking of 28 brands because of problems with transmissions and in-car entertainment systems.Overall, Toyota Motor Corp’s Lexus brand was the top-ranked brand in the magazine’s reliability survey. The highest-ranked Detroit brand was GM’s Buick, at No. 7.Fiat Chrysler Automobiles NV’s Fiat brand came in last.(Additional reporting and writing by Alexandria Sage; editing by Bernard Orr, Christian Plumb and Phil Berlowitz) October 21, 2015 Reuters Tesla Next Article Image credit: Olivier Le Queinec / Shutterstock.com Add to Queue The only list that measures privately-held company performance across multiple dimensions—not just revenue.center_img Consumer Reports Drops Its Tesla Recommendation This story originally appeared on Reuters Apply Now » 2019 Entrepreneur 360 List –shares 3 min readlast_img read more

Read More

Demystifying Predictive Analytics

first_imgDemystifying Predictive Analytics Jamie SchisslerApril 26, 2019, 4:00 pmJuly 22, 2019 What if you had a crystal ball that could tell you which leads are sales-ready and which need some nurturing? Or what type of content will most engage a specific visitor; which customers are most likely to purchase which products and through which channel; or how much demand will increase during peak holiday time?This is predictive analytics: The statistical analysis and identification of attributes that have a direct correlation to a future event or condition. There’s been so much hype about predictive analytics recently that it’s easy to forget it’s been around for over 50 years — from weather forecasting and flight planning to consumer credit scoring and fraud detection. From a marketing perspective, the accuracy it provides and the predictive opportunities it creates can substantially minimize risk while driving tremendous efficiency and performance gains.  What is new is the availability of predictive analytics. Once the luxury and secret sauce for only the largest brands staffed with deep data and analytics teams, expertise, and infrastructure, PA is available to organizations and business of all sizes.So, how can marketers drive adoption, establish predictive analytics competency, and use it to create better outcomes for businesses and experiences for customers? Let’s break down some of the basics. Recognize the power of segmentationTraditional marketing segmentation is about grouping audiences by historical attributes like age, gender, geography, etc. The emphasis of this approach is on understanding what individual consumers have done in the past and/or who they are at this moment in order to better focus and calibrate the brand’s sales and marketing efforts.Predictive analytics can also be thought of as a segmentation strategy. The difference is it employs algorithmic models against much of the same underlying data in order to identify and group customers by what they are likely to do or prefer. As such, it’s useful to think of and approach predictive analytics as a segmentation strategy to identify customers by future behavior, such as those who are likely to travel soon, renew a lease, upgrade, or refer a friend.Read More: How AI will Change the Game for Influencer MarketingDefine specific business cases and develop effective strategiesThinking of it as a segmentation strategy, it’s helpful to begin by defining those groups that represent the greatest opportunities or needs for your business. Perhaps your primary goal is lead velocity. Or maybe it’s churn reduction or lifetime value. Focus on one or two to start, otherwise, you’ll get overwhelmed quickly.After you’ve defined your business and use cases, you’ll need to develop a strategy for how you are going to engage that audience. It’s one thing to be able to identify customers who are likely to do something. It’s another to figure out what that means for your business and how you are going to act on it. Both elements – identification and treatment strategy — are essential.Identify the right data Before rolling up your sleeves and diving into the data science and algorithms, identify the data required for your model. In some cases, you may find you simply don’t have the attributes or volume to create the segment with the degree of probability required. Focus on what you can do with the data you currently have, while simultaneously working on a longer-term roadmap and action plan, complete with business cases.Read More: 3 Ways Mobile Technology is Changing the Brick-and-Mortar ExperiencePrioritize consumer trust and respectA few years ago a Target employee infamously used individual purchase data to build a model that would predict, with tremendous accuracy, which of its customers was likely pregnant. The audience was then subtly targeted with specific relevant products via direct mail. This example provides several important lessons when embarking upon predictive analytics. It underscores the potency and accuracy of predictive analytics while demonstrating that it doesn’t take a huge staff to develop and implement (though it does require a lot of data). More importantly, it demonstrates that in all things, trust and respect matter. The creep factor, invasiveness, and breach of privacy and trust in this application was a bridge too far.To avoid such pitfalls, marketers should ensure there is governance and oversight in how predictive segments are defined and utilized. Socialize internally the segments the organization seeks to create and why, balancing out the needs of the business with customer preference, perception, privacy, and experience.The power of predictive analyticsThe predictive analytics landscape is an incredible opportunity to streamline the customer journey, deliver better experiences and value to your audiences, and boost overall business performance. Brands such as Netflix, through its recommendation engine, and Marriott are using PA to deliver messages at key decision points. Marriott uses it for better insight on the types of travelers likely to stay at their properties; for insight on and understanding of what attracts travelers to it over other brands; and to better understand the unique travel patterns and needs of those who travel for business versus those who travel for pleasure.What’s really exciting is not just what brands can do with PA, but that the variety of PA technologies and solutions available today make it accessible to every organization. Plan carefully and deliberately, advance incrementally, and implement governance that reflects your organizational values and goals and you’ll be on your way to delivering exceptional customer experiences and accelerating growth.Read More: Eye Rolls at Pre-Rolls: How to Escape the Trap of Annoying Ads customer experienceMarketing TechnologyMarriottNetflixpredictive analytics Previous ArticleWhy Senior Business Leaders Should Care About CX DataNext ArticleWhy Measurement is the Secret to Agency Successlast_img read more

Read More

Early genome catastrophes can lead to development of lung cancer in nonsmokers

first_imgThe research team plans to further focus on the molecular mechanisms that stimulate complex rearrangements in the body, through screening the genomic structures of fusion genes in other cancer types.Source:The Korea Advanced Institute of Science and Technology (KAIST)Journal reference:Kim, Y.T. et al. (2019) Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma. Cell. doi.org/10.1016/j.cell.2019.05.013. We hope this work will help us get one step closer to precision medicine for lung cancer patients.” Reviewed by Alina Shrourou, B.Sc. (Editor)May 31 2019Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related lung cancers develop.Researchers at KAIST, Seoul National University and their collaborators confirmed that gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and on average about three decades before cancer is diagnosed. The study showed that these mutant lung cells, harboring oncogenic seeds, remain dormant for several decades until a number of further mutations accumulate sufficiently for progression into cancer. This is the first study to reveal the landscape of genome structural variations in lung adenocarcinoma.Lung cancer is the leading cause of cancer-related deaths worldwide, and lung adenocarcinoma is its most common type. Most lung adenocarcinomas are associated with chronic smoking, but about a fourth develop in non-smokers. Precisely what happens in non-smokers for this cancer to develop is not clearly understood.Researchers analyzed the genomes of 138 lung adenocarcinoma patients, including smokers and non-smokers, with whole-genome sequencing technologies. They explored DNA damage that induced neoplastic transformation.Lung adenocarcinomas that originated from chronic smoking, referred to as signature 4-high (S4-high) cancers in the study, showed several distinguishing features compared to smoking-unrelated cancers (S4-low).People in the S4-high group were largely older, men and had more frequent mutations in a cancer-related gene called KRAS. Cancer genomes in the S4-high group were hypermutated with simple mutational classes, such as the substitution, insertion, or deletion of a single base, the building block of DNA.But the story was very different in the S4-low group. Generally, mutational profiles in this group were much more silent than the S4-high group. However, all cancer-related gene fusions, which are abnormally activated from the merging of two originally separate genes, were exclusively observed in the S4-low group.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSpecial blood test may predict relapse risk for breast cancer patientsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe patterns of genomic structural changes underlying gene fusions suggest that about three in four cases of gene fusions emerged from a single cellular crisis causing massive genomic fragmentation and subsequent imprecise repair in normal lung epithelium.Most strikingly, these major genomic rearrangements, which led to the development of lung adenocarcinoma, are very likely to be acquired decades before cancer diagnosis. The researchers used genomic archaeology techniques to trace the timing of when the catastrophes took place.Researchers started this study seven years ago when they discovered the expression of the KIF5B-RET gene fusion in lung adenocarcinoma for the first time. Professor Young-Seok Ju, co-lead author from the Graduate School of Medical Science and Engineering at KAIST says, “It is remarkable that oncogenesis can begin by a massive shattering of chromosomes early in life. Our study immediately raises a new question: What induces the mutational catastrophe in our normal lung epithelium.”Professor Young Tae Kim, co-lead author from Seoul National University says:last_img read more

Read More

New class of cancerkilling agents shows promise in destroying cancer stem cells

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 9 2019Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone. Taylor and Dr. L.M. Viranga Tillekeratne, a professor in the Department of Medicinal and Biological Chemistry in the UToledo College of Pharmacy and Pharmaceutical Sciences, reported their findings in a paper recently published in the journal Scientific Reports.Cancer stem cells are an intriguing target for researchers because of their potential to re-seed tumors.When doctors remove a tumor surgically or target it with chemotherapy drugs or radiation therapy, the cancer may appear to be gone. However, evidence suggests that a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations.Those cancer stem cells, Taylor said, are similar to dandelions in a well-manicured lawn.”You could chop the plant off, but it will drop a seed. You know the seeds are there, but they’re hiding,” he said. “You pull one weed out and another comes up right after it. Cancers can be like this as well.”Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe small molecule they have isolated appears to lock on to those stem cells and kill them by blocking their absorption of an amino acid called cystine.UToledo was awarded a patent for the discovery late last year.For Tillekeratne and Taylor, uncovering a new class of therapeutic molecules could prove to be an even larger contribution to cancer research than the project they initially envisioned.”At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research. This also shows the beauty of collaboration. I wouldn’t have been able to do this on my own, and [Taylor] wouldn’t have been able to do it on his own.”Tillekeratne has received a three-year, $449,000 grant from the National Institutes of Health National Cancer Institute to continue testing the effectiveness of the newly identified therapy.Because the molecules so selectively target cancer stem cells, it’s possible they could ultimately be paired with other chemotherapy drugs to deliver a more comprehensive treatment.However, the researchers have found their agents show stand-alone promise in treating sarcomas and a subtype of breast cancer known as claudin-low breast cancer, which represents up to 14 percent of all breast cancers and can be particularly difficult to treat. Source:University of ToledoJournal reference:Taylor, W.R. et al. (2019) Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific Reports. doi.org/10.1038/s41598-019-42251-5. Not all cancer cells are the same, even in the same tumor. There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”Dr. William Taylor, professor in the Department of Biological Sciences, UToledo College of Natural Sciences and Mathematicslast_img read more

Read More