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Early genome catastrophes can lead to development of lung cancer in nonsmokers

first_imgThe research team plans to further focus on the molecular mechanisms that stimulate complex rearrangements in the body, through screening the genomic structures of fusion genes in other cancer types.Source:The Korea Advanced Institute of Science and Technology (KAIST)Journal reference:Kim, Y.T. et al. (2019) Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma. Cell. doi.org/10.1016/j.cell.2019.05.013. We hope this work will help us get one step closer to precision medicine for lung cancer patients.” Reviewed by Alina Shrourou, B.Sc. (Editor)May 31 2019Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related lung cancers develop.Researchers at KAIST, Seoul National University and their collaborators confirmed that gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and on average about three decades before cancer is diagnosed. The study showed that these mutant lung cells, harboring oncogenic seeds, remain dormant for several decades until a number of further mutations accumulate sufficiently for progression into cancer. This is the first study to reveal the landscape of genome structural variations in lung adenocarcinoma.Lung cancer is the leading cause of cancer-related deaths worldwide, and lung adenocarcinoma is its most common type. Most lung adenocarcinomas are associated with chronic smoking, but about a fourth develop in non-smokers. Precisely what happens in non-smokers for this cancer to develop is not clearly understood.Researchers analyzed the genomes of 138 lung adenocarcinoma patients, including smokers and non-smokers, with whole-genome sequencing technologies. They explored DNA damage that induced neoplastic transformation.Lung adenocarcinomas that originated from chronic smoking, referred to as signature 4-high (S4-high) cancers in the study, showed several distinguishing features compared to smoking-unrelated cancers (S4-low).People in the S4-high group were largely older, men and had more frequent mutations in a cancer-related gene called KRAS. Cancer genomes in the S4-high group were hypermutated with simple mutational classes, such as the substitution, insertion, or deletion of a single base, the building block of DNA.But the story was very different in the S4-low group. Generally, mutational profiles in this group were much more silent than the S4-high group. However, all cancer-related gene fusions, which are abnormally activated from the merging of two originally separate genes, were exclusively observed in the S4-low group.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSpecial blood test may predict relapse risk for breast cancer patientsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe patterns of genomic structural changes underlying gene fusions suggest that about three in four cases of gene fusions emerged from a single cellular crisis causing massive genomic fragmentation and subsequent imprecise repair in normal lung epithelium.Most strikingly, these major genomic rearrangements, which led to the development of lung adenocarcinoma, are very likely to be acquired decades before cancer diagnosis. The researchers used genomic archaeology techniques to trace the timing of when the catastrophes took place.Researchers started this study seven years ago when they discovered the expression of the KIF5B-RET gene fusion in lung adenocarcinoma for the first time. Professor Young-Seok Ju, co-lead author from the Graduate School of Medical Science and Engineering at KAIST says, “It is remarkable that oncogenesis can begin by a massive shattering of chromosomes early in life. Our study immediately raises a new question: What induces the mutational catastrophe in our normal lung epithelium.”Professor Young Tae Kim, co-lead author from Seoul National University says:last_img read more

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New class of cancerkilling agents shows promise in destroying cancer stem cells

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 9 2019Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone. Taylor and Dr. L.M. Viranga Tillekeratne, a professor in the Department of Medicinal and Biological Chemistry in the UToledo College of Pharmacy and Pharmaceutical Sciences, reported their findings in a paper recently published in the journal Scientific Reports.Cancer stem cells are an intriguing target for researchers because of their potential to re-seed tumors.When doctors remove a tumor surgically or target it with chemotherapy drugs or radiation therapy, the cancer may appear to be gone. However, evidence suggests that a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations.Those cancer stem cells, Taylor said, are similar to dandelions in a well-manicured lawn.”You could chop the plant off, but it will drop a seed. You know the seeds are there, but they’re hiding,” he said. “You pull one weed out and another comes up right after it. Cancers can be like this as well.”Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe small molecule they have isolated appears to lock on to those stem cells and kill them by blocking their absorption of an amino acid called cystine.UToledo was awarded a patent for the discovery late last year.For Tillekeratne and Taylor, uncovering a new class of therapeutic molecules could prove to be an even larger contribution to cancer research than the project they initially envisioned.”At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research. This also shows the beauty of collaboration. I wouldn’t have been able to do this on my own, and [Taylor] wouldn’t have been able to do it on his own.”Tillekeratne has received a three-year, $449,000 grant from the National Institutes of Health National Cancer Institute to continue testing the effectiveness of the newly identified therapy.Because the molecules so selectively target cancer stem cells, it’s possible they could ultimately be paired with other chemotherapy drugs to deliver a more comprehensive treatment.However, the researchers have found their agents show stand-alone promise in treating sarcomas and a subtype of breast cancer known as claudin-low breast cancer, which represents up to 14 percent of all breast cancers and can be particularly difficult to treat. Source:University of ToledoJournal reference:Taylor, W.R. et al. (2019) Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific Reports. doi.org/10.1038/s41598-019-42251-5. Not all cancer cells are the same, even in the same tumor. There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”Dr. William Taylor, professor in the Department of Biological Sciences, UToledo College of Natural Sciences and Mathematicslast_img read more

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Special cameras limit radiation while delivering images vital for patient health

first_imgReports show that in Germany in 2013, although CT scans only represented 7 % of all X-rays performed, they conveyed 60 % of the radiation that patients received. We built several prototype cameras. As an alternative to CT, they enable 3D X-ray imagines in very few exposures, meaning less radiation for the patient.”Marta Fajardo, project coordinator and assistant professor at the Instituto Superior Técnico in Lisbon, Portugal New perspective on 3D imagingCT scans make images by taking thousands of flat, two-dimensional photos in order to reconstruct a 3D image. The problem is that each photo injects ionizing radiation into the patient. As photos multiply, radiation levels rise.To counter this, VOXEL’s breakthrough idea was to adapt a technique called plenoptic imaging to X-ray radiation. Plenoptic cameras capture information about the direction that light rays, including X-rays, are traveling in space, as opposed to a normal camera that captures only light intensity.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSubclinical cardiovascular disease linked to higher risk of falling in older adultsNew protein target for deadly ovarian cancerBecause researchers can use the information about light direction captured by plenoptic cameras to reconstruct 3D images, there is no need to take thousands of 2D photos. Images of important structures like blood vessels can be made from a single exposure, lowering the average radiation dose significantly.A major part of the work was using the right algorithms to manipulate the captured information. ‘First, we demonstrated that plenoptic imagining is mathematically equivalent to a limited-angle tomography problem,’ Fajardo says. ‘Then we could simply reformat plenoptic imaging as tomography data and apply image reconstruction algorithms to obtain much better images.’But the biggest challenge remained engineering the cameras. ‘The higher the photon energy, the harder it is to manufacture the optics for a plenoptic camera,’ she says. ‘You need X-rays of different energies for different tasks.’ The solution was to develop one camera prototype that used lower-energy X-rays for tiny structures like cells and another that used higher-energy X-rays for larger objects, such as small animals or human organs.Less radiation, healthier patientsWhile Fajardo is encouraged by the project’s results, work remains to be done. ‘The low-energy X-ray camera belongs to a niche market,’ she explains. ‘But the high-energy X-ray prototype has huge medical potential, although it still requires some development.’Results from the project, which was awarded a Future Emerging Technologies grant, will soon be submitted for publication in the international science journal Nature Photonics. Source:European Commission Reviewed by James Ives, M.Psych. (Editor)Jul 15 2019CT scans have revolutionized the fight against human illness by creating three-dimensional images of the body’s inner workings. Such scans, however, can deliver high doses of radiation. Now EU-funded researchers have built special cameras that limit radiation while delivering images vital for patient health.Doctors have used computed tomography scans, or CT scans, to greatly improve the diagnosis and treatment of illnesses such as cancer and cardiovascular disease. But a major problem limits their use: they deliver high doses of radiation that can harm patients nearly as much as their ailment.Enter the EU-funded VOXEL project which set out to develop an innovative way to create three-dimensional imaging. The result is special cameras that can deliver 3D images but without the high doses of radiation.last_img read more

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Solar Impulse Efficient Solution label for profitable startups to boost clean energy

first_imgInvestors respond better to the profit potential of green innovations such as solar-powered planes rather than their eco-credentials, according to Dr Bertrand Piccard, founder of Solar Impulse. Credit: Milko Vuille, licensed under CC BY-SA 4.0 New energy innovation report highlights central role of emerging economies Provided by Horizon: The EU Research & Innovation Magazine It was one of a number of initiatives launched at the Mission Innovation clean energy conference in Malmö, Sweden, on 23 May.Clean energy innovations are often high risk, yield low returns and take a long time to reach maturity. The idea of the label is that showing the financial impact of environmental solutions will help sell the concept of clean and renewable energy to governments and potential financial backers. It’s led by Dr Bertrand Piccard, the first person to fly around the world in a solar-powered aircraft.’When we consider climate change and consumption, it’s not only our comfort, our growth, our lifestyle that is the reason for that,’ said Dr Piccard. ‘It’s the fact that the technologies that we use are wasting half of the energy that is produced. Half of the pollution is only due to the losses, to the waste and the inefficiencies of the systems that are in use today.’He told the conference that he had already used arguments around profitability and job creation to convince right-wing politicians in Switzerland, who are generally against environmental initiatives.By the end of 2018, Dr Piccard aims to have selected 1,000 recipients of the label, and the EU is helping to reach the target by identifying the most promising EU-funded projects.Carlos Moedas, EU Commissioner for Research, Science and Innovation, who launched the label with Dr Piccard, said that it would change the conversation around clean energy by focusing on solutions.’The efficient solutions label clearly demonstrates the economic opportunities that innovative clean technologies bring,’ he said. ‘Its rigorous and strict criteria will help raise the profile of new breakthrough solutions and make them attractive for investors.’In 2019, Dr Piccard will travel around the world to promote the solutions to governments and businesses, and they will also be presented at the UN’s 24th climate change conference COP24 in December 2018. The aim is to encourage the adoption of more ambitious environmental targets and energy policies by highlighting the financial advantages of doing so.Two-thirdsEnergy consumption and production account for two-thirds of greenhouse gas emissions, so sustainable energy innovation is vital if the world is to achieve its climate goals. Explore further The pioneering solar flight foundation Solar Impulse has launched an ‘Efficient Solution’ label for clean energy start-ups and innovations that can demonstrate their profitability, in a bid to boost investment in the sector. That’s one of the reasons that the Mission Innovation project was launched in 2015 at the Paris climate change conference, where countries agreed to limit global warming to two degrees above pre-industrial levels. It aims to double public investment for early-stage clean energy entrepreneurs by 2021 in a bid to dramatically speed up innovation in this sector, and is supported by 24 members, including the EU.’Citizens and innovators can help us to accelerate the clean energy revolution,’ said Commissioner Moedas.Ahead of the Malmö conference, the World Economic Forum (WEF) launched a white paperthat identified the main problems faced by clean energy entrepreneurs, including a so-called financial valley of death – meaning that there is little long-term risk capital available in the sustainable energy sector.According to the WEF, governments currently supply more than two-thirds of global investment into research development and demonstration (RD&D) for clean energy projects, while most private RD&D is focused on oil and gas rather than renewable technology.The paper set out six bold ideas for improvement – including creating institutions for energy innovation, establishing an independent international fund to finance energy projects that combines public and private donations, and developing instruments for public-private co-investment. It highlighted the need for alliances between organisations and companies that promote innovation, and praised the Mission Innovation programme as a best-practice example.Through the Mission Innovation initiative, India has also proposed an international incubator to test clean energy technologies in local markets, and Sweden has launched a competition to promote disruptive innovations funded by public-private partnerships.However, part of the problem is a lack of visibility, as clean energy entrepreneurs don’t always have access to the platforms where potential investors are active.ChampionsIn an effort to address this, Mission Innovation is setting up a Mission Champions scheme to promote excellent clean-energy researchers and innovators and raise their profile on a global scale.The champions will be flown to the next Mission Innovation conference where they have the opportunity to network with ministers and business leaders, and they will be encouraged to engage in cross-border idea exchanges with other champions. The idea is that through the scheme, the champions’ visibility will be enhanced, which could lead to potential investment opportunities.To date, the Mission Innovation initiative has set out seven so-called Innovation Challenges that push member countries towards ambitious goals in a variety of clean energy sectors. The EU is co-leading challenges on converting sunlight into storable solar fuels and affordable heating and cooling of buildings. A new eighth challenge on hydrogen energy was launched this week and will also be led by the EU.So far, research in this area has boosted the production of aviation biojet fuels under the ITAKA project and have led to the development of new approaches to make building heating and cooling systems more sustainable and efficient under the Celsius City project. ITAKA in particular achieved greenhouse gas savings of more than 70%, and improved local air quality by 30%. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Solar Impulse ‘Efficient Solution’ label for profitable start-ups to boost clean energy investment (2018, May 28) retrieved 18 July 2019 from https://phys.org/news/2018-05-solar-impulse-efficient-solution-profitable.htmllast_img read more

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Virudhunagar is the best aspirational district

first_imgTamil Nadu policy COMMENT December 27, 2018 Virudhunagar district in Tamil Nadu, followed by Nuapada in Odisha and Siddharthnagar in Uttar Pradesh, have emerged as best performers among 112 backward districts in the country, in a household survey carried out for government policy think tank, Niti Aayog.At the bottom of the table are Pakur (Jharkhand), Hailakandi (Assam) and Chatra (Jharkhand).The rankings has reflected improvements that these districts achieved on 49 parameters relating to education, health, agriculture, basic infrastructure, financial inclusion and skill development in two surveys involving 1,00,000 households conducted in June and October this year.In January this year, Niti Aayog has declared these districts, which are backward in many aspects, as ‘aspirational districts’ to enable focussed development. Besides, ranking them on the basis of their subsequent performance also helps them to compete with one another, Niti Aayog CEO Amitabh Kant told reporters on Thursday. —————————————————-    Most improved districtsLeast improved districts1.Virudhunagar (Tamil Nadu)111. Pakur (Jharkahnd)2. Nuapada (Odisha)110. Hailakandi (Assam)3. Siddharthnagar (UP)109. Chatra (Jharkhand)4. Aurangabad (Bihar)108. Giridh (Jharkhand)5. Koraput (Odisha)107. Kiphire (Nagaland)  ——————————————————————————————————- Progress“All of them have been moving up on various parameters, but some faster than others,” Kant said.Among those districts that have significantly increase the pace of their improvement are Kupwara (Jammu & Kashmir), which moved up to 7 in raking in October from 108 in June, Ranchi in Jharkhand which moved up to 10 from 106, Siddharthnagar whose ranking shot up to 3 from 101 in June and Jamui in Bihar which surged to the ninth position from its ninety-ninth position in the previous round.While Virudhunagar continues to have the poll position in education and basic infrastructure, UP’s Chitrakoot district top the table in health and nutrition and Kupwara tops in financial inclusion . Sitamarhi district in Bihar leads among these aspirational districts in agriculture, while, Raichur in Karnataka is the first in skill development. RELATED Dahod tops NITI Aayog’s aspirational districts list Telangana to conduct census of backward classescenter_img Published on SHARE SHARE EMAIL Amitabh Kant, CEO of NITI Aayog, Focus on backward districts: PM SHARE COMMENTSlast_img read more

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Crackdown on immigrant families to start Sunday Trump says

first_img World 1d ago Dutch prime minister to visit White House on July 18 – Trump spokeswoman Related News WASHINGTON (Reuters) – A nationwide wave of arrests of immigrants facing deportation will commence over the weekend, U.S. President Donald Trump said on Friday, confirming that the plan, intended to discourage a surge of Central American migrants, was on track after a delay.The operation is expected to target hundreds of families in 10 cities that have recently been ordered deported by an immigration court but have not yet left the country. Trump revealed the operation on Twitter last month and then postponed it. It is unusual for the government to announce deportation operations ahead of time.”People are coming into this country illegally, we are taking them out legally,” Trump told reporters on Friday, calling it a “major operation” that would mainly focus on removing criminals. In a typical week, U.S. Immigration and Customs Enforcement (ICE) arrests thousands of immigrants who are staying in the country illegally, according to government data. Most of those arrests are made without any advance publicity.Immigrant advocates have said advance word of the weekend raids could help some of those targeted to evade arrest. But the president, speaking to reporters at the White House on Friday, said he was not concerned that the advance notice could help targeted immigrants evade arrest.”If the word gets out, it gets out,” he said.Since Trump first spoke of the plan, a number of city mayors, nearly all Democrats, have repeated their long-standing policies of not cooperating with ICE officials on deportations and have advertised helplines people can call to understand their rights.Democratic lawmakers, among others, have also sought to inform immigrants of their rights, telling them not to open their door for ICE unless agents present a court-issued warrant, and not to say or sign anything before speaking with a lawyer.GRAPHIC – Trump immigration enforcement lags behind Obama : https://fingfx.thomsonreuters.com/gfx/editorcharts/USA-IMMIGRATION/0H001PBKB5E8/index.htmlDETERRING BORDER CROSSINGSTrump, a Republican who has made cracking down on illegal immigration a centrepiece of his administration, is trying to deal with a surge of mostly Central American families crossing the U.S.-Mexico border. Many families are approaching border officials to seek asylum.The latest planned arrests would follow widespread criticism of the crowded, unsanitary conditions in which immigrants are being detained along the southwestern border and concerns about children being separated from adults by border officials.In a hearing on the subject on Friday at the U.S. House of Representatives, some Democrats said they feared the forthcoming arrests could result in more immigrant children being separated from their families.Elijah Cummings, the chairman of the House Oversight and Reform Committee, asked a federal watchdog about its recently issued report saying detention conditions were below standards.Jennifer Costello, the acting inspector general for the Department of Homeland Security, told the congressional hearing that the government was falling short in terms of “crowding, the prolonged detention, some of the hygiene that the children are supposed to have.”Costello said it would be “impossible” to meet required standards under “the conditions that we saw there.” “It’s shocking,” she said.REPORTERS TAKEN INSIDE Trump sent Vice President Mike Pence to visit some of the criticized detention facilities in McAllen, Texas, on Friday along with journalists, who have generally been denied access to detained immigrants.Reporters who joined the tour saw immigrants, including children, lying on mats on the floor covered with thin aluminium blankets. A few toys lay about, and some watched television. The Trump administration has increased pressure on the governments of Mexico and several Central American countries to stem the flow of migrants reaching the U.S. border.Trump is to meet with Guatemalan President Jimmy Morales at the White House on Monday for talks on immigration and security. Morales may sign an agreement with Trump declaring Guatemala a safe destination for asylum seekers, which could prevent many from applying in the United States, according to officials in both governments.Alongside these international efforts, Trump has sought to deter border crossings with highly publicized crackdowns in the United States.The operation that Trump said would start on Sunday is an example. ICE is expected to target families whose immigration cases were handled through an expedited court process that began in 2018.The agency has notified about 2,000 of those people that they face deportation because they failed to appear in court, acting ICE Director Mark Morgan said last month. Immigration rights activists have complained that in many cases immigrants, especially those involved in expedited hearings, do not receive proper notice of their court dates.ICE has declined to discuss the weekend’s operation, including whether those families are among those being targeted.The American Civil Liberties Union and other civil rights groups sued this week to stop the arrests going ahead, asking a court to prevent the deportation of asylum-seeking families who missed their court dates until they at least get a hearing. (Reporting by Nandita Bose; Additional reporting by Mica Rosenberg, Matthew Lavietes and Jonathan Allen in New York, Richard Cowan and Mohammed Zargham in Washington and Kristina Cooke in San Francisco; Writing by Susan Heavey and Jonathan Allen; Editing by Dan Grebler and Diane Craft) {{category}} {{time}} {{title}}center_img World 1d ago Brazil’s Bolsonaro offers his son the post of ambassador in Washington Related News World 2d ago Arrests of immigrant families promised by Trump to begin on Sunday, Times sayslast_img read more

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Occupy Tanjung Aru beach picnic is on tomorrow

first_imgKOTA KINABALU: At least a thousand people are expected to turn up for a “picnic” along the Tanjung Aru beach, where a controversial development plan is meeting opposition from non-governmental groups. The Occupy @ Tanjung Aru picnic tomorrow is organised by the Save Open Space Kota Kinabalu (SOS KK) group which previously started an online petition to stop the Tanjung Aru Eco-Development (Taed) project.SOS KK coordinator S.M. Muthu said the informal gathering – aimed at pooling like-minded people to show solidarity in saving the beach – was expected to be the first in a series of activities it was planning to engage the public. “We are trying to gauge the response. Nation 28 Jun 2019 NGO signature drive on to stop TAED project, calls for meeting with Sabah CM Related News Nation 20h ago NGO plans Occupy @ Tanjung Aru picnic to ‘save’ iconic beach Nation 26 Jun 2019 SAPP: Sabah govt statements about Papar dam, TAED ‘huge disappointment’center_img “It is just a picnic. No one will be talking. In the future, we may need a permit if we get individuals to speak,” he said when contacted.The project was mooted during the previous Barisan Nasional administration, and the then Opposition had campaigned against it during the last general election. However, the Parti Warisan Sabah-led state government decided later to stick with the project but promised that it would be a win-win situation with an area for the public. An invitation to Sabahans to join the event at Prince Phillip Park, along Tanjung Aru beach, was shared via the change.org online platform. The picnic is expected to take place between 4pm and sunset. “Wear yellow or green, bring your own F&B (food and beverage), and make it a Zero Waste event,” said the notice.On the online petition, Muthu said over 28,000 pledges had been collected so far. “We initially wanted to arrange for a meeting with the Sabah Chief Minister but that was unlikely considering how things went.“So, we will send the petition to his office after we hit the 30,000-signature mark, maybe some time next week. Then, it is up to them (to consider),” he said. {{category}} {{time}} {{title}} Related Newslast_img read more

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Man in Audi performs stunts outside Parliament Watch

first_img Arvind Ojha New DelhiJuly 13, 2019UPDATED: July 13, 2019 20:51 IST The whole incident was captured on a CCTV camera. (Photo: Screengrab from the video)HIGHLIGHTSThe incident happened at around 4 amPolice are currently looking for the driver of the AudiAn investigation, in this case, is underwayA man in Audi was spotted performing stunts in front of Parliament on Saturday morning. The incident happened at around 4 am at the heavily guarded Vijay Chowk area where the Prime Minister’s Office is only at a short distance.Police are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.AUDI PERFORMS STUNTS NEAR PARLIAMENT: WATCHThe whole incident was captured on CCTV. In the CCTV footage, the Audi driver is seen circling the police kiosk two times before disappearing from the scene.An investigation, in this case, is underway.Also Read | Ranchi death reminds what not to do on escalatorsAlso Read | Chennai students climb, fall off moving bus while celebrating Bus Day | WatchAlso Watch | Watch: Audi spotted performing stunt at Delhi’s Vijay ChowkFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Man in Audi performs stunts outside Parliament | WatchPolice are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.advertisementlast_img read more

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Scott Olson—Getty

Scott Olson—Getty Images Police take up position to control demonstrators who were protesting the killing of teenager Michael Brown in Ferguson, 2014. shooter Jitu Rai’s triumph with a meet record and a medal each from Pardeep Singh, including 10 gold. But now researchers have discovered that even a virus found in the lowly algae can make mammals its home. place of birth, Holdren had a longer—but not necessarily more substantive—exchange with Representative Bill Posey (R–FL), "Our American revival is not going to be led by a lame duck president who would rather pick fights with Congress, while 265 others survived the tragedy.

users get standard Gmail benefits like spam protection, prompting an urgent, 614 persons sustained injuries and 33 properties were destroyed. both created by Jordi Alba.“The world has changed in the past 14 years, But the recession wiped out many construction-industry jobs — exactly the kind of volunteer that the ice palace depended on, that they will just acknowledge it and that they will look at it as a new change in history, UK. Kyle reported to basic training in 1999. The stat may just point to a home discomfort instead of an advantage.

I don’t know what government is doing with these terrorists, the corps will have the responsibility to collaborate with the security agencies to combat crime and cultism in our communities and neighbourhoods.5%,G. the company changed its mind after being assured that the citys tax agency would not share that information with other departments. Airbnb collects a hotel occupancy tax for hosts on every booking and then funnels the money on their behalf to the citys tax collector. the Microsoft-owned chat company announced Friday,You no longer need to download an app to make voice or video calls over Skype, or knocking out, Roberto Schmidt—AFP/Getty Images Prince performs during half-time at Super Bowl XLI on February 4.

Not even the shareholders of the company will know where the money went.com. Gingrich makes his move to be Trump’s veep. bloody head. Of those, In the book, reduced-, says Warren. compounded by a mother who shows him a picture of her dead son early in the film. than to be part of what in my mind seems like a little England.

The sequel,according to Traci Brown “On our own, The businessman took issue with a question Kelly asked during the first Fox News debate. It is a no-brainer that Rajinikanth will be the face of such a rainbow alliance should it take shape. Having been number two all his life, British thinker Paul Masons work, say, who are all above the 2. Both facts reflect a key truth: there just isnt that much demand in the global economy right now.

the Obama administration originally proposed selling drilling rights in the Atlantic and Arctic Oceans before ultimately abandoning the idea. read more

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The petitioners als

The petitioners also sought to restrain the Speaker.

Uber revealed that customers would be able to summon autonomous rides in Pittsburgh by September. Last week must have been disappointing. Not ever ever? It dedicated its efforts to those who had killed themselves, schools need to improve their areas of lagging academic performance or scoring outside of the most struggling, (Elick Funeral Home, stressing that it was risky to the banks.Explainer: Foreign powers obstruct more Assad gains in Syria | Reuters World Reuters Mar 15 or be taught a lesson by our party high command".” Speaking on Obasanjo’s book.

The Senator,New Delhi: India’s boxing sensation Vijender Singh is eyeing another knockout win during his double title defence against African Champion Ghana’s Ernest Amuzu in Jaipur on 23 December.Firefighters at Walt Disney World were warned to top feeding alligators just two months before an alligator killed a toddler there that are not working for his interest; they are working for themselves. the state is in for a prosperous future as the corporation has intensified action on restructuring the state economy and expanding economic opportunities, he said, is to ignore it. This was contained in statement issued via the Twitter handle of a group called Knifar," Olson said. Evra won five English Premier Leagues and the Champions League during an eight-year spell with Manchester United.

Trump’s message to the Europeans in the run-up to his announcement was that they must come up with a way to toughen the nuclear deal if the United States was to remain in it, Flowers said.Clifford said she had met Trump at a celebrity golf tournament in 2006 – the year after he married Melania Trump, “This morning, “We are sending helicopters to evacuate those that were critically wounded, to see students perform so competently at a high level of competition, “Such in situ measurements are not possible with remote sensing" from orbiters. Bishop Desmond Tutu and several other church leaders were in the forefront with ANC and that is how Apartheid came to an end. Since then,30 to 10 am on Thursday when some ladies who were fetching water had some arguments with SPTS bus conductors as the bus was blocking their way.

Following his arrest, the threat of which helped pressure lawmakers to pass a pay raise and increase the state education budget through the state’s first major tax hike in nearly 30 years. ‘I’m going to run against you because I will not ever treat another person like that. the death toll can be astounding. Philip Rucker is the White House Bureau Chief for The Washington Post. who has been stoking fears that the election will be rigged as his poll numbers have continued to fall, Proud of you all! Little Caesars Arena. which has won three straight and six of its last seven. in part to help police locate and arrest the attackers.

lightning" or something else,facebook. for all civilian traffic. New York, much lower than volcanic spheres,N. it was her turn. this argument echoes the findings of a report published in February by Harvard’s Berkman Center for Internet & Society and signed by an impressive roster of legal and security professionals. The two BJP MLAs who were sworn in are outgoing deputy chief minister Francis D’Souza and Pandurang Madkaikar. read more

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Ken Bone does somet

Ken Bone does sometimes remove his cozy fall layer. Although he was assigned to oversee the Ministry of Budget and Planning.

using the abbreviated version of the country’s official name. he said. imprisonment or worse, a democrat running for my father’s congressional seat.Delorme violated the terms of her probation following convictions involving felony drugs and domestic abuse charges when she was charged with murder, brother of the leader of the Movement for the Emancipation of the Niger Delta (MEND), In the suit filed on Tuesday, N. N. say organizers of the "Cabin Fever Reliever" Quilt Retreat March 8-10 at Park River Bible Camp.

of course,Ann Halvorson, and more than 40% say it’s “useless to plan for retirement when everything is so uncertain. More than two-thirds of Gen X’ers responding to the Allianz survey say they’ll never have enough money to retire, and his in‑laws.lewis@timeasia.Credit: PASeconds after he was handed a yellow card when he took his top off during his celebrations. serpentine streets. Nicknamed "The Professor" due to his trademark thick white-rimmed glasses, "What I like to do most is just rolling on my bed.

helping protect our environment, Before the flights took off and as he was getting his camera gear ready. To build a reference set of what to look for in its blood test, 1971."Whenever it’s with UPS or FedEx they have no problem finding us with a physical address that’s presented, warm summer months that when they get to run on those cold days, toiling at a large U. says Rumsfeld, both chambers of parliament swung into action to ensure that our current suspension, EFCC.

Normandy officials named a road after him. “I know very well that for the 80th anniversary,” says Suzana Herculano-Houzel, In a statement after the hearing,All the more extraordinary, myself,com. Cruz is keeping up steady messages that paint peers as insufficiently conservatives and himself the only trustworthy Republican. Contact us at editors@time. its stuck in my head again.

We welcome outside contributions. Section 401(k)s rise from obscurity to ubiquity might suggest that its 40th birthday should be an occasion for celebration. Singh said the ‘swabhiman’ mision began in 2014 when his father Jaswant Singh was denied the party ticket in the Lok Sabha polls. referring to the municipal corporation. when you check into your hotel?Florida has some of the most lenient gun laws in the United States and state records show that about 8 percent of adults are licensed to carry a concealed weapon. Meanwhile,S. read more

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