MOST READ Ateneo, La Salle gather momentum for coming crucial clash Ed Daquioag and Rey Nambatac heeded that call and mounted sterling performances, and led the Painters to a 91-85 decision of the Batang Pier at Mall of Asia Arena to become the first semifinalists in the PBA Philippine Cup.No. 1 Phoenix Pulse later followed suit, destroying eighth-ranked Alaska, 91-76, in the nightcap.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsJason Perkins scored a career-high 31 points that went with nine rebounds as the Fuel Masters posted the one-sided win for the franchise’s first semifinal stint.“Before the game started, I told the players that the only thing I’m worried about is our first quarter,” Garcia told reporters, citing that they haven’t played any competitive basketball—even a tuneup at that—since defeating Meralco in their final elimination round game on March 15. The winner of the Ginebra-Magnolia series advances to the survivor of the Phoenix Pulse-Alaska quarterfinal, which the Fuel Masters are trying to wrap up at press time.Rain or Shine drew significant contributions from old reliables Beau Belga, who had 13 points, and Gabe Norwood, who finished with eight.Sports Related Videospowered by AdSparcRead Next Private companies step in to help SEA Games hosting Daquioag and Nambatac had solid outings coming off the bench, with Daquioag finishing with a team-best 15 points on an efficient 71 percent shooting.Nambatac, meanwhile, chipped in with 14 more.“They were guarding James (Yap) throughout the whole game so it paved the way for the other players to step up,” Garcia said. “We know how dangerous the guards of GlobalPort have been and Mo (Tautuaa) has become a totally different player from the first time he came into the league. We really had problems matchup wise.”The second-ranked Painters now await the winner of the San Miguel Beer-TNT series, which the Beermen lead, 1-0, and can wrap up on Monday in the 7 p.m. game at Smart Araneta Coliseum in Cubao.Barangay Ginebra is also leading sister team Magnolia in the other best-of-three series, with the Gin Kings to also take the first of two shots at closing out the Hotshots in the 4:30 p.m. contest.ADVERTISEMENT LATEST STORIES Hontiveros presses for security audit of national power grid Philippine Arena Interchange inaugurated DA eyes importing ‘galunggong’ anew PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss SEA Games hosting troubles anger Duterte Panelo: Duterte ‘angry’ with SEA Games hosting hassles Cayetano: Senate, Drilon to be blamed for SEA Games mess Coach Caloy Garcia’s biggest worry for Rain or Shine coming into Sunday night was how his Elasto Painters would be opening their quarterfinal match against NorthPort coming off a long break.He had such a simple marching order that his charges followed to the letter: “At any given time, step up.”ADVERTISEMENT Don’t miss out on the latest news and information. Duterte wants probe of SEA Games mess View comments
TagsTransfersAbout the authorCarlos VolcanoShare the loveHave your say Barcelona comms chief Vives denies Valdes kicked out back doorby Carlos Volcano15 days agoSend to a friendShare the loveBarcelona comms chief Josep Vives denies the club kicked Victor Valdes out the back door.Valdes was sacked as U19 coach this week.Vives said, “It is a technical decision and it is not the responsibility of any spokesperson. The club always tries to make people, not just the referents, leave in the best way possible. “We disagree with the issue that Valdés has gone out the back door.”He added: “It always hurts when a person leaves the club, and more with the history of Victor. The club wanted it to work well and that his stage was long and successful.”
(A screen grab of the truck James “OJ” Pitawanakwat was driving on Sept. 11, 1995, moments before it hit an RCMP IED during the Gustafsen Lake standoff. YouTube)Jorge Barrera APTN National NewsA Wikwemikong man who was given political asylum in the U.S. following the 1995 Gustafsen Lake armed standoff in British Columbia wants to return to Canada.James “OJ” Pitawanakwat, 44, has lived in the U.S. since August 1998 when he crossed the border while on day parole in Canada.The U.S. Federal Court for the District of Oregon denied Canada’s extradition request for Pitawanakwat in November 2000 on grounds his actions in B.C. were “of a political character” and qualified for an exemption under the extradition treaty between Canada and the U.S.“I would like to go back home to live and come and go throughout Canada and come and go throughout the U.S. without this harassment,” said Pitawanakwat, who is originally from Wikwemikong on Manitoulin Island in Ontario.He said there is still an active warrant out for his arrest in Canada.Pitawanakwat was convicted by a B.C. court in 1997 of mischief and possession of a weapon for a purpose dangerous to the public peace in connection to his involvement in the summer standoff which saw more gunfire exchanged between warriors and police than during the 1990 Oka Crisis.He was sentenced to three years in prison, but was released on day parole after one year. Nine days into his day parole, Pitawanakwat, who was in Surrey, B.C., at the time, said he “just walked right across” the U.S. border. As a First Nation man, Pitawanakwat can legally live on both sides of the border.“I eventually started going across American and showing people the video of the truck explosion,” said Pitawanakwat.(John “Splitting the Sky” Hill describes explosion triggered by RCMP IED. YouTube)The video of the truck explosion is one of the most striking images of the Gustafsen Lake standoff. It was Sept. 11, 1995, and Pitawanakwat was driving with a woman activist, an AK-47 along with a rifle inside the pick-up truck, his dog Idaho in the back. They were roaring down a logging road when they hit an RCMP installed improvised explosive device (IED). The truck flipped in a plume of dirt and smoke, Pitawanakwat and the woman managed to escape the vehicle, but Idaho was shot by an RCMP sniper.“I remember driving down the road and then an explosion just rocked my world and disorientated me for a quick minute and my combat senses kicked-in and survival set in,” he said. “I relive that moment every day of my life.”Pitawanakwat said he and the activist managed to cross the lake where a cache of weapons was hidden. Some of the other warriors also arrived and began to open fire on the RCMP’s Bison armoured personnel carrier, borrowed from the Canadian Forces.“When I reached the treeline I armed myself and returned to the guts of the conflict on the battle field. The armoured personnel carrier was disabled by small arms fire and by the trees. It knocked out the steering column,” he said. “We just put suppression fire on the other Bison when it started roaring out of nowhere and was shooting people. It was straight out war.”James “OJ” Pitawanakwat during the Gustafsen Lake standoff in 1995. YouTubeThe Gustafsen Lake standoff centred on land leased by the province to a rancher near 100 Mile House, B.C., that was used for Sundance ceremonies. The land, which was never surrendered, was reclaimed by the Ts’Peten Defenders in 1995 who refused to leave despite attempts by the rancher to evict them.The RCMP intervened, and, with support from the Canadian Forces, faced down the Ts’Peten Defenders, who numbered between 30 to 40 people, according to the U.S. Federal Court record.Things escalated in mid-August when Defenders spokesperson William “Wolverine” Jones Ignace said if the RCMP moved into the camp it would be “clearly war…We’re not going to go peaceful. Body bags or do a hell of a long stretch…Nobody is going to tell you to put your weapons down,” according to the court record.The RCMP and the Canadian Forces, working through Operation Wallaby, set up a base camp called Camp Zulu which included armoured personnel carriers, helicopters, a field hospital, communication centre, military assault weapons and a tactical unit of about 400 “heavily armed militarized police,” according to U.S. court records.After several incidents, which saw tens of thousands of rounds exchanged between both sides, the Defenders’ camp surrendered by Sept. 17, 1995.There were 18 people, 13 men and five women, at the camp by the stand-off’s end. All 18 were convicted by a jury following a 10-month trial, according to the U.S. court record.Despite Canada issuing a warrant for his arrest shortly after he fled across the U.S. border, Pitawanakwat managed to evade capture for a little less than two years.He was finally arrested in Lincoln City, Ore., in June 2000, after he went out to buy pizza on his bicycle.“I found out U.S. Marshals were on my tail. One morning they swooped in and got me,” he said. “They converged on me, on my bike and I fled into the thorns. They arrested me and took me to Portland, Ore.”James “OJ” Pitawanakwat, 44, in Mount Pleasant Michigan. He wants to come home to Canada. Photo courtesy of family.U.S. Federal Court Judge Janice Stewart, however, denied Canada’s request for extradition, ruling that Pitawanakwat’s activities at Gustafsen Lake qualified for exemption under the extradition treaty for activity of “a political character.”“The Lake Gustafsen incident involved Indigenous people rising up in their own land against the government of that land. Although the crimes were committed while trespassing and occupying private property, the type of property occupied makes this case unique,” said Stewart, in her ruling. “(The rancher) acquired title to the land through the Canadian government, but this land included tribal land over which Native people believed they had a valid legal claim. Thus, the protest by the Ts’Peten Defenders was directed largely against the Canadian government which had granted (the title)…In addition, the violence was aimed…at the Canadian government and its military forces.”Pitawanakwat was preparing to find a lawyer to help build his case for a final return to Canada earlier this year, but tragedy struck his life in Mount Pleasant, Mich., when his step-son attacked both his mother and Pitawanakwat with a knife.Juan Romero, 22, is accused of stabbing his mother in the face. Pitawanakwat said he was stabbed seven times. Local reports say he was flown to hospital with multiple stab wounds.Romero is currently undergoing a psychiatric assessment and his case is on hold, according to an Isabella County court official. Romero is facing two counts of assault with intent to murder, among other charges.Pitawanakwat was also hit with a sexual assault related charge shortly after the incident, but the case was dismissed on Sept. 10, 2015, according to a court official.“The prosecuting attorney was not ready to proceed with the case,” said the court official.The prosecutor Robert Holmes did not return a call seeking comment.Pitawanakwat’s desire to return to Canada is getting support from one of the most prominent members of the Gustafson Lake standoff, Secwepemc Elder “Wolverine” Ignace.Wolverine recently wrote Prime Minister Justin Trudeau and Justice Minister Jody Wilson-Raybould a letter requesting they call a public inquiry into the events of the 1995 standoff.“Such an inquiry would expose the Canadian government’s genocidal relationship with Indigenous peoples,” said Wolverine, in an emailed response to questions from APTN. “Specifically, the cover-up of the genocidal actions of the federal provincial government during the Ts’Peten-Gustafsen standoff of 1995.”Wolverine said he hoped an inquiry would help allow Pitawanakwat to return home.“James has been in exile for 20 years,” he said. “As an Indigenous man, he has the right to come home. He is an adopted member of (Wolverine’s family), of the Secwepemc Nation as a whole.”Wolverine has also called for a gathering of “Allied” Tribes to meet on Sunday in Secwepemc territory to discuss the recent call for a national inquiry into the 1995 standoff and Pitawanakwat’s firstname.lastname@example.org@JorgeBarrera
The Warriors were 17-4 during the regular season with average shooting. That equals a .810 winning percentage — tops in the the NBA — or the equivalent of a 66-16 record over an 82-game schedule.The reason for the Warriors’ strong record with average shooting is simple: They also play great defense. It gets overlooked because they play at a frenetic pace, but the Dubs held opponents to a .514 TS% during the regular season, the third-best figure in the league after Chicago and Portland.It can get even worse for opponents, and it often does: The Warriors went 46-3 with good shooting during the regular season. But “pretty good” shooting — average shooting, even — is usually plenty good enough for the Warriors. They’ll need to throw up a lot of bricks the rest of the way. Otherwise, James — as brilliant as he’s been — may become the first finals MVP in a losing cause since Jerry West in 1969. Through the first three games of the NBA Finals, the storylines were intricate and rich:Could LeBron James carry one of the worst supporting casts in recent finals history to an NBA title?Was James’s experience — and sheer force of will — trumping the Golden State Warriors’ youth?Was Steph Curry just in a shooting slump, or was he rattled by his scary injury against the Houston Rockets?Could the Cleveland Cavaliers keep playing stifling defense, or might Golden State’s smallball lineup be its ace in the hole?Were Cleveland’s poor finishes — it was outscored by a combined margin of 105-84 in the fourth quarter and overtime of the first three games1And if you include Game 4, it’s now been outscored 132-96 from the fourth quarter onward. — the sign of a spent team?Was Kevin Love’s injury (suffered in the opening round against the Boston Celtics) the ultimate example of Bill Simmons’s Ewing Theory? And maybe Kyrie Irving’s injury too?Is Matthew Dellavedova the Australian Tim Tebow?Does God hate Cleveland?But after a 103-82 Golden State win in Game 4, it all seems so simple.The Warriors are really, really good. You have a shot at beating them if their shooting goes ice-cold. Otherwise, it’s next to impossible.Let’s review the series from the standpoint of true shooting percentage (TS%), a relatively simple stat that gives appropriate credit for 3-pointers and free throws along with 2-point shooting attempts. Golden State led the NBA with a .571 TS% during the regular season, while Cleveland (.557) ranked fourth. The adjacent table lists each team’s TS% in each finals game so far, along with its percentile rank as compared to all NBA games during the 2014-15 regular season.Game 4 was the first time we’ve seen the Warriors shoot like they typically did during the regular season. Their .579 TS% was close to their regular-season average, and — since an average Golden State performance is so good — ranks in the 77th percentile as compared to all NBA games.But the Warriors’ defense has also been very good. It held Cleveland to a .409 TS% in Game 4, which ranks in just the 1st percentile. And it kept the Cavaliers to a .441 TS%, in the 6th percentile, in Game 2 on Sunday night.Wait — didn’t the Cavs win Game 2? They did (in overtime). The team with the higher TS% wins about 85 percent of the time2Based on the 2014-15 regular season. — this was one of the exceptions. Cleveland was able to take seven more field-goal attempts and 15 more free-throw attempts than the Warriors as a result of rebounding, turnovers and fouls. You can win as the slightly less efficient team when there’s a big differential in those categories.Still, Cleveland wouldn’t have won Game 2 had Golden State shot a little better. If the Warriors had hit shots at the NBA average TS% of .535 (never mind that the team’s TS% is typically way better than that), they’d have scored an additional eight points and won 101-95.And that’s the thing: The Warriors don’t have to shoot the lights out to win. If they shoot as well as the average NBA team, they’re very likely to win also.In the next chart, I’ve tracked each team’s record based on its TS% during the regular season. I divide games into three categories, which include about a third of regular-season games each:Good shooting — a TS% of .560 or higher.Poor shooting — a TS% of .510 or lower.Average shooting — anything in between.
It was 49 degrees and windy. The river in front of Griggs Reservoir Boathouse was cold and full of debris.It’s unlikely that it’s the first place many people want to be at 8 a.m. on a Monday morning, but the Ohio State’s women’s rowing team was out on the water.The Buckeyes’ expectations are high this season, as they are ranked No. 1 in the College Rowing Coaches Association/U.S. Rowing preseason top 20, and have two consecutive championships under their belt. OSU backed up those preseason accolades with 18 wins in its first 22 races of the season, spanning across four meets.Annie Jachthuber, a freshman rower, said the team is incredibly dedicated to the sport and the high stakes motivate them to work hard every day.Jachthuber added that she has been rowing since her senior year in high school, where she tried many different sports. But she said rowing was her favorite because of the team dynamic.“I don’t do things for myself; I like to do things for other people,” she said.After Monday’s practice, Jachthuber walked into the boathouse, which opened in 2011, and through a white hallway lined with pictures of the team’s past successes. There are two types of pictures: Those with the smiling faces of champions, and action shots filled with faces of concentration.Jachthuber turned through a doorway and joined the other rowers in the OSU team room, which is full of floor-to-ceiling windows that face the waterfront in the middle of the boathouse.Coach Andy Teitelbaum, who has been with the rowing program since its birth in 1995, stood in the center of the room surrounded by his team, all of it bathed in the morning light reflected off the water. He dished out final words before the team huddled together, putting their hands in for a last hurrah before the rowers headed off to class.When asked how he feels about the team’s current rank and the pressure to perform, he jokingly said he was “outraged.”But then Teitelbaum laughed, saying he is filled with pride and that the team performs in “tremendous fashion.”With a wide smile he added, “This group is outstanding.”Teitelbaum said the road to the two championships and the team’s current standing have been humbling and that he is quite pleased with the status of his team.Jachthuber echoed her coach’s feelings and said one day her grandmother called and asked if there was ever a time when Jachthuber did not feel like pushing herself. She said she had replied, “No.” She said the dedication of the other girls and the solidarity while practicing drives them all, no matter how unfavorable the elements might be.“I love being a part of something bigger than myself,” Jachthuber said. “You do it for each other.”With seven meets standing between the Buckeyes and the Big Ten Championships on May 16, OSU is set to return to the water against Minnesota on Saturday. Fittingly, the races are set to begin at 8:15 a.m. in Columbus.
Scouting Northern KentuckyThe Norse have had a rough time getting things going this season, compiling a 12-22 record that includes an abysmal 6-19 road record. The one thing that has gone well for the Norse this year has been their ability to produce at the plate. As a team, they are batting .275 with 36 home runs so far this season, including a pair of hitters with eight home runs and four regulars batting above .300. The team has scored a total of 211 runs, averaging 6.21 runs per game. Its star bat this season has been junior first baseman and pitcher Trey Ganns. Ganns has eight home runs, while his .310 batting average is sitting as the team’s second-highest among starters. Ganns, the team’s cleanup hitter, has demonstrated an acute ability to clean up the bases, leading the Norse with 32 RBIs this season.Scoring runs has not been an issue for the team. Rather, the issue has been keeping the opponents from scoring runs of their own. Across 287.2 innings the season, the Norse have posted a team ERA of 6.41, which ranks 260th out of 295 Division I programs. Pitchers have struggled to limit contact, having surrendered 364 hits this season (.370 opponents’ average). Finding More Consistency in the OffenseThe Buckeyes’ inability to keep the bats going for extended periods of time has been cited by coach Greg Beals as the chief issue for the team.After the team took two of three against Penn State with a combined 16 runs over the final two games of that series, the OSU offense mustered just two combined runs against a pair of midweek opponents in Cincinnati and Eastern Michigan, and was shut out by Michigan State in its first of the three games in the past weekend’s series. “We’ve been working really hard just with our offensive approach,” Beals said in a press conference last Thursday. “The two midweek games, we didn’t score enough runs to win the game, especially Wednesday night’s game, we pitched the ball really, really well.”Though his team has shown a lot of signs of struggle, Beals said he believes the talent is there for his team to start putting it all together, and he hopes his bats can click in opportune moments.“Each of the guys in our offensive lineup have shown signs of greatness, and we’ve got to find a way to get that out more consistently, and it’s an approach thing that we’ve got to do,” Beals said. “We’ve got to make sure that we are locked in on the pitches we are going to get and be consistent in that approach throughout an at-bat and be able to string some quality at bats together to produce some runs.”The Buckeyes hope to get that offense going again when they take on Northern Kentucky on Wednesday with first pitch scheduled for 6:35 p.m. Then-junior outfielder Tre’ Gantt is greeted by teammates outside the dugout after scoring a run over the weekend in the Big Ten/Pac-12 Challenge in Surprise, Arizona. Credit: Courtesy of Press Pros MagazineOhio State (15-21, 4-8) has been on the road for a while.It’s had some midweek home games mixed in there, but the past two weekend series have been on the road for the Buckeyes.Now OSU is getting a chance to enjoy some home cooking with its second nine-game homestand of the season, which will kick off on Wednesday with a matchup against the Northern Kentucky Norse (12-22, 6-6 Horizon League).The Buckeyes found little success the last time they played nine consecutive home games, amassing a 4-5 record and a 1-4 record in conference games.
Manchester United are reportedly attempting to complete a £55m deal for Toby Alderweireld from Tottenham, claims Manchester Evening NewsThe defender is widely expected to leave Spurs in the summer after falling out of favour with head coach Mauricio Pochettino over the course of this season.While the Argentine remains keen to tie down Alderweireld to a new long-term contract, Spurs are reluctant to match the Belgian’s wage demands.The Norton London side are currently not in a position to be forced into anything with Alderweireld as they have the option to renew his current deal by another year, meaning that the 29-year-old will have to wait until 2020 to leave the club as a free agent.Maguire says United need to build on today’s win George Patchias – September 14, 2019 Harry Maguire wants his United teammates to build on the victory over Leicester City.During the summer, Harry Maguire was referred to as the ultimate…However, Alderweireld will have the option himself to activate a £25m release clause for the remaining two weeks of the 2019 summer transfer window.In light of this, it seems almost certain that Pochettino will sell the defender with Davinson Sanchez having performed well in the heart of the Spurs defence in Alderweireld’s place.Jose Mourinho has been alerted to this latest development and has identified Alderweireld as someone that will fit in well with his system at United.The Portuguese coach has grown tired of Phil Jones and Victor Lindelof’s struggles and will be in the market for a new centre-back this summer.
Facebook0TwitterEmailPrintFriendly分享Update -Friday According to Anchorage Police only minor injuries were sustained during the two vehicle collision. UPDATE 11:50amBoth lanes of the Seward Highway have been reopened at Mile 109. The closure is valid from 10:57 a.m., until 2:57 p.m. Original PostThe Seward Highway is closed near milepost 109 due to a crash/vehicle fire according to the Department of Transportation. According to the DOT, drivers should watch for police and fire trucks on the highway. Limited details are known at this time, updates will be posted as they are made available.
RYAN POPPEAbbott Campaign Mail-in Ballot ApplicationGov. Greg Abbott’s campaign to register mail-in ballot applications for seniors ahead of the deadline is creating costly headaches for many county election officials. During a primary election season, campaigns will try to help senior citizens register for mail-in ballots. But Texas election officials, including Bexar County’s election administrator Jacquelyn Callanen, are mailing back hundreds of applications, all of them linked to one campaign.“When we receive a primary election, we receive a number of mail-in ballot applications from a number of campaigns and we started to receive some last week that did not have a party check on them,” Callanen said.Those incomplete applications came from Abbott’s re-election campaign and were mailed not only to seniors that voted Republican in the last election but also to traditional Democrat and independent voters, according to the campaign.Campaign spokesman John Wittman said part of its effort is to attract voters who don’t traditionally vote in a Republican primary.“This mail-in ballot application drive is result of a test that Texans for Greg Abbott did in 2014. This election, we’ve expanded it 10-fold,” Wittman said.Glen Maxey, who heads up the Texas Democratic Party’s mail-in ballot campaign, was one of the first to notice problems with the Abbott application, which he said is decorated with the Abbott campaign logo and has very small printed instructions informing the voter they must indicate whether they need a Democrat or Republican mail-in ballot.“This application is about six-point type. A person of age — such as myself — I can’t read the application even with my glasses,” Maxey said.Callanen said it is costing individual counties hundreds of dollars to reject the incomplete applications, and the extra effort of sending out all the rejection letters is slowing down her office’s productivity.The deadline to submit an application for a mail-in ballot is Feb. 23. Share
The Lambda Kappa Omega chapter of Alpha Kappa Alpha will hold their annual Kozy Kerchief & Kozy Kaps program at the Vienna Presbyterian Church, 124 Park St. NE, on Oct. 24 from 8 a.m. until 4 p.m. The event will take place on National Make A Difference Day and consist of AKA members and volunteers creating, sewing and hand delivering head wraps for women and children undergoing cancer treatments at local hospitals.For more information, visit aka-lko.org/programs/kozy-kerchief-kozy-kaps
(Phys.org)—A pair of researchers at Duke University has built a library of protein data that outlines the specific amino acid sequences that control changes of many elastin proteins. In their paper published in the journal Nature Materials, Felipe García Quiroz and Ashutosh Chilkoti describe their research, the making of their library, and their belief that what they have created will help in the development of new synthetic designs for possible use in medical applications. Citation: Researchers develop a library of elastin-like proteins to help in creating synthetic designs (2015, September 23) retrieved 18 August 2019 from https://phys.org/news/2015-09-library-elastin-like-proteins-synthetic.html Proteins assemble and disassemble on command This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers, Nature Materials (2015) DOI: 10.1038/nmat4418AbstractProteins and synthetic polymers that undergo aqueous phase transitions mediate self-assembly in nature and in man-made material systems. Yet little is known about how the phase behaviour of a protein is encoded in its amino acid sequence. Here, by synthesizing intrinsically disordered, repeat proteins to test motifs that we hypothesized would encode phase behaviour, we show that the proteins can be designed to exhibit tunable lower or upper critical solution temperature (LCST and UCST, respectively) transitions in physiological solutions. We also show that mutation of key residues at the repeat level abolishes phase behaviour or encodes an orthogonal transition. Furthermore, we provide heuristics to identify, at the proteome level, proteins that might exhibit phase behaviour and to design novel protein polymers consisting of biologically active peptide repeats that exhibit LCST or UCST transitions. These findings set the foundation for the prediction and encoding of phase behaviour at the sequence level. Journal information: Nature Materials © 2015 Phys.org Explore further Proteins are organic compounds essential to all living organisms, they are especially prevalent in components that have structure, such as muscle, skin, hair, etc. They provide structure by self-forming into different shapes under different conditions, two of which are solubility and temperature. Proteins are made of sequences of amino acids—the order and type of which drive the shape of the protein when certain conditions are met. Scientists still do not quite understand how proteins self assemble into the specific 3D shapes they take, nor which amino acids lead to which shapes, or indeed, how the order in which they exist contributes to those shapes. To help provide a better understanding of how it all works, Quiroz and Chilkoti set about building a library of all the known elastin-like proteins, along with the shapes they take under different conditions. They based it on the sequences of five key amino acids found in the fibrous protein typically found in connective tissue, such as muscles. They then set about testing each entry in the library by growing samples of E. coli engineered to produce proteins that folded into different shapes under different conditions. Most specifically noted was under which conditions the proteins shifted from being soluble to non-soluble and vice-versa. That work led them to developing a set of rules that loosely defined which amino acid sequences would result in which shapes under which conditions.The research duo acknowledge that their rules are more like guidelines, but suggest the basis of what they have built can not only be made stronger with more research by them and others, but can be used to assist in creating synthetic proteins for use in developing targeted drugs. One example would be protein capsules that remain insoluble inside the body until a certain condition is met, at which point, a medication would be released.
Kolkata: A youth from Sonarpur in South 24-Parganas sustained head injuries after being hit on his head by a local miscreant. The incident occurred on Saturday morning when the victim protested against the accused as he was hurling abusive language at his wife. The accused has been arrested. Police said the victim, identified as Susanta Mondal protested against the accused, Madan Mondal who had allegedly abused his wife. A heated altercation broke out between the two when the victim demanded an apology from the accused. The altercation soon led to a scuffle following which the accused youth hit him on his head with a rod. One of the victim’s associates, Ram Naskar, who came to his rescue also received injuries in the incident. The accused fled the spot immediately after the incident but he was later arrested. The locals rushed both the injured victims to a nearby healthcentre. The locals told the police that the accused has been involved in various anti-social activities and often used to abuse women. A case has been initiated after the family members of the victims lodged complaints.
The BBC reported its “best March ever” for the iPlayer, with viewing figures helping the catch-up service to reach its third-best month on record.The Assassination of Gianni VersaceCommenting on the stats, Dan McGolpin, controller of programming and daytime for the BBC, said that Q1 2018 was the BBC’s “strongest first quarter ever” for the iPlayer.Drama was the big draw in March with 19 of the top 20 most popular iPlayer episodes fitting this genre.“Drama continues to have an extraordinary year on BBC iPlayer,” said McGolphin. “Building on a brilliant January and February, this month drama fans were treated to captivating US drama like The Assassination of Gianni Versace as well as world-class British programmes like Collateral, Strike and the ever-brilliant Call the Midwife.”Episode one of The Assassination of Gianni Versace was the most-watched programme of the month with 1.62 million requests, while episodes of Collateral, Eastenders and Strike: Career of Evil made up the rest of the top-five most-requested shows.Overall, 315 million programmes were viewed in March, up 15% on the same month last year, with 10.2 million daily requests.The BBC said that March 2018 sits just behind January 2018 and December 2017 as one of the best BBC iPlayer has ever seen. According to company stats the iPlayer had 328 million programme requests in January and 327 million in December.
21st Century Fox has agreed to sell its 39% stake in Sky to Comcast after the US pay TV giant emerged triumphant from an intense bidding process over the weekend.Rupert MurdochWith the move Rupert Murdoch, who is chairman of 21st Century Fox, cashes out his interest in Sky – a company that he launched in the UK nearly 30 years ago.Comcast’s £17.28 (€19.23) per share offer for Sky values Fox’s stake in the business at £11.6 billion. In a statement Fox congratulated Comcast on its pending acquisition.“When we launched Sky in 1989 it was four channels produced from a prefab structure in an industrial park on the fringes of west London,” read the Fox statement.“We bet – and almost lost – the farm on launching a business that many didn’t think was such a good idea. Today, Sky is Europe’s leading entertainment company and a world-class example of a customer-driven enterprise.”Disney, which is in the process of acquiring most of 21st Century Fox’s TV and film assets in a separate US$66 billion deal that was agreed in December, consented to Fox’s sale of its Sky stake.The company said that the Sky deal, combined with the divestiture of the Fox Sports Regional Networks, will significantly reduce the amount of debt it will incur in acquiring 21st Century Fox.Disney CEO Bob Iger said in a statement that the proceeds from both Sky and Fox Sports Regional Networks will “substantially reduce the cost of our overall acquisition and allow us to aggressively invest in building and creating high-quality content for our direct-to-consumer platforms to meet the growing demands of viewers.”Commenting on Fox’s decision to sell its Sky stake to Comcast, Sky CEO Jeremy Darroch described the deal as the close of one chapter and the opening of another.“Nearly 30 years ago Rupert Murdoch took a risk to launch Sky and in the process changed the way we watch television forever,” said Darroch.“His vision and belief has enabled us to grow in to Europe’s leading direct-to-consumer media business and I would like to personally thank him, James [Murdoch] and 21st Century Fox for their consistent support as shareholders, board members and friends.”21st Century Fox had previously moved to take full control of Sky but was eventually outbid by Comcast in a sealed bidding process that concluded at the weekend.Comcast’s bid of £17.28 per share represented a premium of 125% on the company’s price at the end of 2016, just before 21st Century Fox made its initial approach for Sky. Fox placed a final bid of £15.67 per share for Sky.Sky said at the weekend that it was in the best interests of all Sky shareholders to accept the Comcast offer, while Fox’s immediate reaction was to say it would consider its options regarding its own 39% stake in the company.
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