The chief of the UKs state-funded National Health Service (NHS) Sir Malcolm Grant has embarked on a four-day trade mission to India with a delegation of 13 top British healthcare providers to promote collaborations between the two countries in the healthcare sector.The Chairman of NHS England is leading the team alongside Healthcare UK and Department for International Tradeï¿½to promote innovation in healthcare and collaborations between India and Britain in the healthcare sector.Read it at India Today Related Items
Source:https://benthamscience.com/ Jun 29 2018Cancers control immune systems and evade immune detection using mediators consisting of immune checkpoint molecules and cellular systems associated with immune suppression.In this review, the complexity of immune-suppressive mechanisms in the tumor milieu of cancers, including oral malignancy is discussed in relation to immune check point inhibitors, regulatory T cells (Treg), myeloid-derived suppressor cells (MDSCs) and cancer-associated fibroblasts (CAFs). In addition, the therapeutic approach of oral pre-cancerous disorders is mentioned. Some reports also advocate that the immunosuppressive efficacy of the oral squamous cell carcinoma (OSCC) milieu is developed in a stepwise manner depending on the stages of OSCCs. Namely, in the early stage, CAFs could be a unique effector; humoral factor(s) from OSCC cells force CAF to exert immune suppression via the direct cell contacts to effector T cells. Potentiated CAF could also affect other immune-suppressive mediators such as Treg, tumor-associated macrophages (TAMs) and MDSCs. In the advanced stage of OSCC, MDSCs could possibly be a major conductor of immune-suppression. However, how OSCCs differentially utilize the immune modulatory aspects involving CAFs, MDSCs and several other factors is not fully understood. Further elucidation of the regulatory pathways structured by tumor-host interactions could identify important therapeutic targets in OSCC development.