Tag: 上海千花网

City Shows off Plans for First Phase of Alameda Point Redevelopment

first_img Dan Cohen AUTHOR The city of Alameda hosted residents at an event last month to show off plans for a major component of Alameda Point and to celebrate the most recent property transfer from the Navy at the former Naval Air Station Alameda.The 2.5-mile walking tour focused on the city’s plan to redevelop the area surrounding Seaplane Lagoon, which calls for several large parks, a 500-acre federal wildlife habitat, housing, retail and a ferry building. Site A is slated to have 800 homes, including some reserved for low-to-middle-income residents, and 600,000 square feet of commercial and retail space, reported the East Bay Times.“This is a completely unique opportunity,” said Alameda City Planner Andrew Thomas. “There’s nothing like the Seaplane Lagoon in the Bay Area. As Alameda residents, you should be thrilled.”One of the parks will provide a stunning view of downtown San Francisco, the lagoon and a decommissioned aircraft carrier. One goal of the event was to build interest among residents and park enthusiasts for the city’s plan to turn another portion of the site, now a concrete slab, into a park.“We need people to know about ‘De-Pave Park’ so when it comes to advocating for money to build it, we have people contacting their representatives,” Thomas said.Mayor Trish Spencer is confident the city has come up with the right formula for reusing the site. “We’re all excited about the new development,” Spencer said. “It’s been almost 20 years since the base closed.”The city is directing the project itself. Its development team includes commercial builder srmErnst, retail company Madison Marquette, residential developer Thompson Dorfman Partners and nonprofit Eden Housing. The team hopes to start on the first phases of the project within the year, according to the story.last_img read more

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VIDEO Learn About Wilmingtons CARES Program

first_imgWILMINGTON, MA — In the latest episode of WCTV’s “Where’s Wilmington,” host Lisa Kapala interviews Sheri Palmer, Program Coordinator for Wilmington CARES. Learn about the district’s before-school and after-school program, which currently has approximately 600 families enrolled — roughly 200 kids in the morning and 450 kids in the afternoon.Watch the 13-minute interview below, courtesy of Wilmington Community Television:—Video Playerhttps://objects-us-east-1.dream.io/wilmington/f/c/a/6/4/9/fca64974-0bc7-4c8f-aba1-0c481313fd831546529923.416%2B51312622.460%40castus4-wilmington%2B15469604041546957533084667.vod.720p.20190101-Where%27s_Wilmington_Ep_134_CARES.mp4Media error: Format(s) not supported or source(s) not foundmejs.download-file: https://objects-us-east-1.dream.io/wilmington/f/c/a/6/4/9/fca64974-0bc7-4c8f-aba1-0c481313fd831546529923.416%2B51312622.460%40castus4-wilmington%2B15469604041546957533084667.vod.720p.20190101-Where%27s_Wilmington_Ep_134_CARES.mp4?_=100:0000:0000:00Use Up/Down Arrow keys to increase or decrease volume.—Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedVIDEO: Learn About The New Wilmington Police Explorers ProgramIn “Videos”VIDEO: Meet Wilmington Recreation’s New Program Coordinator Bret SawinIn “Videos”VIDEO: Learn About The Mill City Eagles, A Local Semi-Pro Football Team, & Meet GM Zachary Swale, Of WilmingtonIn “Videos”last_img read more

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AFRO Exclusive Social Media Star B Simone Dishes on Life and Her

first_imgBy Micha Green, AFRO Washington, D.C. Editor, mgreen@afro.comFor those who haven’t stumbled across her rants, raps, skits and famous “B. Simone tone” on Instagram, her improvisational comedy on “Wild ‘N Out” or her music, B. Simone is becoming a name to know and remember.  The entertainer with 2.1 million followers on Instagram is now on a nationwide comedy tour that is making a stop in D.C. on Dec. 26, and she is inviting people to come learn more about her and have a fun night of laughs.“It’s about my life, my personal life.  My comedy’s about my relationship, sex life, what I’ve been going through with men and it’s just super relatable. And I’ve turned tragedy and heartbreak into comedy,” B. Simone told the AFRO.Instagram and “Wild ‘N Out” star B. Simone will be in D.C. on Dec. 28 at City Winery in Northeast, D.C.The rising star has not always been a comedienne, but she has always been an entertainer.“I come from a background of girl groups and R&B pop singing. So I started off   wanting to be a singer honestly.  I’ve been in five girl groups.  I moved to Atlanta from Dallas to pursue music and acting. And social media is what made me a comedienne,” she said.Even in the earlier days of social media, with sites such as MySpace, B. Simone was active.“I’ve been doing it a long time before Instagram.  I’ve been on Instagram for almost four or five years.  So it’s not like I just blew up overnight.  It took me a while to get to this point, and it’s consistency and constantly putting out content,” she said.However, it has only been recently, through her Instagram fame, that she gained recognition and became a true comedienne.“I started doing ranting videos,” she told the AFRO. “I didn’t even know it was comedy, I was talking to the camera about relatable topics and my followers just thought I was funny.  I was just being myself, so they made me a comedienne,” the millennial entertainer explained.This is B. Simone’s first time taking her comedy on the road.“I’ve been on stage with people who have been doing standup for 20, 15, 10 years.  I’ve only been doing standup for 11 months.  So I’m very new at it, but I have the privilege of growing with my fans,” she told the AFRO.Despite being a neophyte to the comedy game, from the looks of the sold out shows, her first tour is going well.“Almost every single show has been sold out, and it’s just an amazing, amazing experience,” B. Simone said.B. Simone (center) with “You’re My Boooyfriend Comedy Tour,” co-stars Darren Brand (left) and Desi Banks.Although she’s doing well on the road, the path to getting in the door was not easy.“We decided to put on the tour and my manager really fought for me,” she explained.  These clubs are like, ‘Who is B. Simone?’… ‘Is it Bruce Bruce?  Is it Kevin Hart?  Is it DeRay Davis?  How is she going to sell tickets?’ And they just had to have faith that my fans are going to come out and support.Simone, who is doing her own promo for the show, thanked Instagram and her followers for her success on and off the road. She isn’t fazed by the haters who question her trajectory, “just because she’s Instagram famous.”“It just shows that you can do anything you want to do.  The world is different,” she said. “But I’m going to use my platform to make money.  And the world is going to excel and move forward.“I’m going to use it and I’m going to move forward in a positive light. I don’t take any of it for granted.  I say it all the time- Instagram put me in a different mindset of what I can really, really do.  I’ve touched so many people,” she told the AFRO.“So I encourage young Black women to use it to your advantage.  I don’t care if you’re a doctor, and you need more people in your doctor’s office, or if you’re an actress…  That platform is needed for whatever occupation you’re in,” she said.The entertainer is also an entrepreneur.  A licensed cosmetologist who practiced 15 years, B. Simone is launching an upcoming vegan, cruelty-free makeup line and encouraged her followers to stay tuned for when its released.In the meantime, the comedienne is grinding on the road with the “You’re My Boooyfriend Comedy Tour” featuring Desi Banks, with whom she famously collaborates on skits, and “Wild ‘N Out” co-star Darren Brand.  The D.C. stop is on Dec. 26 at City Winery the Ivy City (1350 Okie St NE, Washington, DC 20002).“It’s going to be an amazing show.”Click here for tickets and for all things B. Simone, follow her at @thebimone2 on Instagram.last_img read more

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In search of a suitable girl

first_imgHardly has any novel been awaited with as much curiosity and anticipation in recent times as Vikram Seths sequel to the monumental ‘A Suitable Boy’ (1993). Five years on, since he was first expected to deliver the manuscript, the novel is still to see the light of the day. But what seems like a saga of missed deadlines can very well – far from our eyes – be a masterpiece in the making.”The more I talk of her, the more shy she becomes,” Seth had told this correspondent in 2015 about ‘A Suitable Girl’, the novel-in-waiting. Also Read – Add new books to your shelfSeth, as his literary agent David Godwin puts it, has been known to take his time with his books. The prolonged delay, however, was not acceptable to Hamish Hamilton and he was asked to return an advance payment of $1.7 million when the deal was called off. Weidenfeld and Nicolson, an imprint of the British publisher, then acquired the novel – and it was scheduled to release in 2016. But a flying bird – a friend and confidant of the writer – says that he is now giving the “final touch” to the novel and that one can expect “the big announcement” soon. Also Read – Over 2 hours screen time daily will make your kids impulsiveSeth released a collection of poems titled ‘Summer Requiem’ in the meanwhile. In the collection, he traces the immutable shiftings of the seasons, the relentless rhythms of a great world that both “gifts and harms”. Composed as they were while he was (which he still is) writing the sequel, several poems in the offering open doors to his mind, or perhaps they may be preludes to the larger narrative that he is weaving. “I have so carefully mapped/the corners of my mind/that I am forever waking/in a lost country,” he writes in the opening poem. Interestingly, Seth’s companion to ‘A Suitable Boy’ will be a jump sequel – the characters have travelled from the 1950s and it will be very much a novel set in somewhat the present times. In its title poem, he mourns that the “liberated generation lives a restrained youth,” and then adds: “I must forsake attachment”. On another occasion in the book, readers find him lamenting over “the peaceful love” that the narrator has “never found”. In another short poem “Late Light” he writes: “Outside the great world’s gifts and harms/ There must be somewhere I can go/To rest within a lover’s arm/At ease with the impending snow”. Reportedly, Seth suffered from writer’s block after his break-up with French violinist Phillippe Honor but that was a long time ago and was reflected in ‘An Equal Music’. He has moved on or has he not? Nonetheless, it has been about five years since ‘A Suitable Girl’ was first expected to hit the stands but the wait is surely worth it. As writer-politician Shashi Tharoor says about his good friend’s technique – that “Vikram Seth draws an entire roadmap of his novel, planning every minute element in great detail” – the sequel, thanks to all the anticipation and the pressure on the writer, may actually be a masterpiece in the making, as sublime as its counterpart and yet set in the time of its readers. Vikram Seth is a recipient of the Padma Shri, Sahitya Akademi Award, and among several other prestigious honours, the Pravasi Bharatiya Samman. He has been widely translated and is among leading novelists on the global stage. He has published three novels – ‘The Golden Gate’ (1986), ‘A Suitable Boy’ (1993) and ‘An Equal Music’ (1999) – along with several collections of poetry such as ‘Mappings’ and ‘All You Who Sleep Tonight’. Seth – an openly gay man – is also one of the prominent faces of the campaign against Section 377 of the Indian Penal Code that criminalises homosexuality.last_img read more

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October 16 2006 Arcosanti produce won many awards

first_imgOctober 16, 2006 Arcosanti produce won many awards at this years Yavapai County Fair. Foundry staff Joan Lundell, among others, helped to set-up at the recent Fair. Arcosanti produce won many awards at this years Yavapai County Fair. Foundry staff Joan Lundell, among others, helped to set-up at the recent Fair. [Photo: Sarah Beth Kurzhals text: Rafael Carvao] Sarah Beth Kurzhals, the present Agriculture Manager, is collecting some of the Arcosanti produce for the fair. Vegetables and fruit from the gardens are served in the meals prepared in the Cafe, and also sold during farmers market in the Arcosanti cafe, once a week, for visitors and residents. [Photo: Sarah Beth Kurzhals & text: Rafael Carvao] On a beautiful night, in the Camp Gardens last week, all of the community had the pleasure to enjoy the good atmosphere and all home-made dinner prepared with the award winning produce grown in the Arcosanti Gardens. [Photo & text: Rafael Carvao]last_img read more

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Texas School Board Rejects Expert Review of School Texts

first_imgShare68TweetShareEmail68 SharesNovember 18, 2015; Christian Science Monitor and Texas TribuneAccording to the Christian Science Monitor, on Wednesday, November 18th, the Texas Board of Education rejected a proposal for “letting university experts fact-check textbooks approved for use in public-school classrooms statewide, instead reaffirming a vetting system that has helped spark years of ideological battles over how potentially thorny lessons in history and science are taught.”The proposal was prompted by continuing problems in what has been a highly politicized process. Writing for the National Education Association, Tim Walker describes the influence wielded by the Texas Board of Education on U.S. textbooks:National publishers usually cater to its demands because the school board is probably the most influential in the country. Texas buys 48 million textbooks every year. No other state, except California, wields that sort of market clout.The state of Texas will only fully fund schoolbook purchases by local school districts if the texts are on the state’s approved list. The board “relies on citizen review panels—often teachers, parents, business leaders, or other experts— whose members are nominated by board members” to review proposed texts prior to Board consideration.Last week, that body rejected a proposal to ensure that the authorized textbooks were factually accurate: “Other Texans can also check the books on their own and identify what they see as errors in public testimony during board meetings.”Concerns about the weaknesses of this approach were heightened this fall. The Texas Tribune noted that “controversy over the materials flared up…after Pearland mother Roni Dean-Burren posted a screen shot…of an infographic in [a] McGraw-Hill World Geography textbook that read, ‘The Atlantic Slave Trade between the 1500s and 1800s brought millions of workers from Africa to the southern United States to work on agricultural plantations.’ The backlash prompted an apology and correction from the publisher.”Valerie Strauss described a list of issues raised in the Washington Post in 2014.For example, ideas promoted in different books include the notion that American democracy was inspired by Moses and Solomon, that Jews views Jesus Christ as an important prophet, that in the era of segregation only “sometimes” were schools for black children “lower in quality” and that the U.S. economic systems run without significant government involvement. Some of the books also said that evolution should be taught to students as if it were not fact but simply a scientific theory, and that global warming is not a very serious problem confronting the world. Some critics pointed out simple factual errors, such as the number of Sikhs who live around the world.Those opposed to adding a new level of expertise feared that the proposal “would send a signal that the current textbook adoption process isn’t sound and unnecessarily add an additional layer of bureaucracy to the process. They also took issue with a provision in the amendment that said the state’s education commissioner could appoint Texas-based academics to the panel, with at least one board member noting the ‘philosophical differences’ that often emerge between the board and professors who review proposed textbooks.”Thomas Ratliff, who proposed the change, “quipped Wednesday that he knows ‘people are concerned about pointy-headed liberals in their ivory towers’ getting more involved in the textbook adoption process, but said that creating the option of having such a review panel would demonstrate that the board is concerned about such errors and is actively doing something to address them.”In the end, Texas decided to not go with more expertise. For students outside of Texas, changes in the publishing industry seem to be limiting the state’s influence:Jay Diskey, executive director of the Association of American Publishers’ School Division, says fears of a Texas-style national social studies curriculum are overblown because publishers are more accustomed nowadays to producing customized textbooks for different states.For the millions of Texas children, however, let’s hope the board will rethink their decision.—Marty LevineShare68TweetShareEmail68 Shareslast_img read more

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Prisabacked Portuguese media group Media Capital

first_imgPrisa-backed Portuguese media group Media Capital has signed a deal with Microsoft to make video content available on MSN in Portugal.The agreement will give MSN’s three million unique monthly users access to about 1,200 videos each month, covering fiction, news and entertainment. Media Capital will be responsible for the commercialisation of advertising opportunities on its content.last_img

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TiVo has passed the 25 million subscriber milesto

first_imgTiVo has passed the 2.5 million subscriber milestone in Europe for the first time.TiVo said its advanced TV platform now covers almost half of Virgin Media’s subscribers and a third of ONO’s. The platfor has also been adopted by Swedish cable operator Com Hem in Europe.TiVo recently began showcasing its full hybrid QAM/IP and IPTV offering. According to the company, this platform is designed to work within cable operators’ existing architecture to implement advanced television as operators continue to transition to video delivery over IP. The solution can be migrated between either network while providing the same TiVo functionality including integration of linear, on-demand, catch-up and over-the-top services.Com Hem’s launch of TiVo in October 2013 was the first such full hybrid QAM/IP and IPTV deployment.“Consumers globally are increasingly demanding a superior TV viewing experience that enables them to access content across multiple screens and devices anytime and anywhere. Our growing roster of international pay-TV operator partners including Com Hem, Virgin Media and ONO recognized this trend early and share TiVo’s vision for the future of TV consumption,” said David Sandford, vice-president, general manager, iInternational at TiVo.“TiVo leads the market in multi-screen, TV Everywhere capabilities with deployments across multiple third party set-top boxes, iOS and Android operating systems and the Web, and Europe represents the largest share of TiVo deployments worldwide to date. Our success here puts a fine point on the overall success of TiVo’s strategic transformation to a major international advanced television platform and services company. We are extremely pleased with the strong and sustained rate of adoption throughout Europe.”last_img read more

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Several readers have asked why I use CDs in so man

first_imgSeveral readers have asked why I use CDs in so many examples. With good reason, they wondered if I was suggesting buying CDs, which made them question my wisdom and sanity. If anyone thinks that’s what I’m recommending, I must have been remiss in conveying my message. On that note, I’d like to make one thing clear: I am absolutely opposed to buying any CD denominated in US dollars. (And since we’re clearing things up, I should also mention again that I am wholly opposed to TIPS.) When I use CDs in examples, I am usually referring to a lost time when they paid around 6% – a time when retirees could sail along on CDs and top-rated bonds without much worry. Since the first TARP bill passed in 2008, we’re hard pressed to find a CD paying more than about 1.2%, which is 0.5% below the government-reported inflation rate. It’s also 6.8% below the Money Forever Reader Poll Inflation Rate. Declining interest rates have hit retirees’ investment income hard; for many folks it’s dropped 50-80% from just a few years ago. So why would anyone want to make a long-term investment that is not keeping up with inflation and likely won’t catch up anytime soon? I certainly wouldn’t, and I strongly urge all readers to find other places to put their hard-earned money. Here is the bottom line: Before the 2008 crash, retirees could earn a decent yield on relatively safe investments. For many, this investment income was three to five times more than their Social Security checks, which allowed for a comfortable retirement low on financial stress. Now those same secure investments might bring in income equal to about half of your Social Security check. Before my wife Jo and I were married, we made one of our wisest investments: pre-marriage counseling. We had both been married before, and we wanted to make sure this marriage would be our last. One of our counseling assignments was to write down what we each wanted to be doing in 10 and 20 years. Our counselor also asked us to describe what “enjoying our golden years” meant to us. We took our assignments seriously, and as luck would have it, our dreams meshed quite well. We still consider ourselves truly blessed 25 years later. Some of the things we wanted were no-brainers. We wanted good health and enough money to not have to worry about it. While jetting around the world would be nice, our needs for happiness were much simpler. She grew up on a farm and my dad delivered mail; cool stuff is a bonus but not mandatory. We also wanted companionship to enjoy many things together and freedom to enjoy a few things apart. You get the point; we wanted the same things most ordinary people want. Nevertheless, having enough money to not have to worry about it turned into a trickier challenge than we’d expected. I retired at age 62. For the first six years, it was a dream. We lived in a motor home for a year and traveled extensively, nary a care in the world. Quite frankly, Jo and I were having a blast! That changed overnight, when the banks called in our high-yield, secure CDs. As I received more and more questions from readers about why I write about CDs so often, the more I realized what they had represented to us: freedom. Today we have enough money, but most of our capital is in riskier investments than FDIC-insured CDs. What investment could be more worry-free than a government-insured CD paying three times the rate of inflation? Moreover, it wasn’t just the yield that made us comfortable; safety was also key. If our government collapsed it was all over anyway, at least that was our thinking. The only folks I know who still have that same level of emotional comfort are retired federal employees. I can report that I now sleep much better than I did in 2008. However, it is still a far cry from our carefree joyride when I first retired. I know Jo and I are not alone. The Employee Benefit Research Institute (EBRI) does an annual survey on retirement confidence. Its 2012 survey reports that in 2005, 40% of retirees felt “very comfortable” that they had enough money to live on throughout their retirement years. Forty percent reported they were “somewhat comfortable.” In 2012 those numbers changed to 21% and 42% respectively. Also, in 2005, 7% reported they were “not at all” comfortable; that figure jumped to 19% in 2012. Here are some other interesting tidbits from that report: Americans’ retirement confidence has plateaued at the lowest levels seen over the last two decades. With her marriage, she got a new name … and a dress.  A will is a … dead giveaway. And my favorite: Police were called to a daycare where a three-year-old was … resisting a rest. Until next week… Twenty-five percent of those currently working say the age at which they expected to retire changed in the last year. In 1991, 11% of workers said they expected to retire after age 65, and by 2012 that grew to 37%. Baby boomers are now retiring at a rate of 10,000 per day and will continue to do so for the next 19 years. For decades, through economic ups and downs, they formed their retirement expectations. Now, in a few short years those expectations have been drastically altered.Back to the Future Thanks to the reader feedback I mentioned earlier, I have come to another conclusion: baby boomers on either side of the retirement cusp understand the problem, but they don’t all know what to do about it. Retirees have to make a detour; a bridge is out, and it won’t be repaired anytime soon. I can talk about 6% CDs all day long, but the truth is, they no longer exist. How can we achieve our retirement dreams in the current environment? Our retirement goals have not changed. We still want enough money to not have to worry about it. How we go about getting there, however, has been changed dramatically. So let’s focus on the task at hand. Personally, I advocate a three-pronged approach. First, we have little choice but to put a whole lot more of our nest egg at risk. We need to beat our current, high rate of inflation and earn enough to adequately supplement our Social Security checks. This means continuing to learn about and monitor our investments much more than we had to in the past. We have to diversify our investments to minimize the overall risk to our portfolios, and look into alternative investments and strategies. An uneducated or passive investor is setting himself and his family up for disaster. Second – and this is the part no one likes – we have to modify our lifestyles. That means different things for different people, but no matter how much money you have, we all have to live within our means. That’s just good, old-fashioned common sense. I’ve noticed that folks who accept the reality of our economic problems have an easier time making adjustments. They made sensible cutbacks early on and are damn happy they did. On the other hand, our friends who thought we were in an 18-month recession are hitting some real rough patches. Third and finally, we need to redefine “don’t have to worry about it” to fit today. When Jo and I were traveling the country in our motorhome, Internet connections were spottier than they are today. We would check into a campground and ask if they had an Internet hookup. If they did, we would check our email and update our brokerage account. If not, no big deal; hopefully we would find one at the next campground. That was the epitome of not worrying about it. Not worrying looks a lot different today. We know and understand where our money is invested, and we continue to learn every day. While I would use the word “comfortable” to describe our situation, it’s still a far cry from our carefree, passive attitude of yesteryear. That was a dream… and a whole lot of fun while it lasted. Nevertheless, an educated, confident investor can still sleep very well. If you’re up counting sheep and worrying about your portfolio, skip the Ambien. Instead, I invite you to learn about Miller’s Money Forever and take advantage of our no-risk, premium subscription. If you decide it’s not for you, just call or email within the first 90-days and receive a 100% refund. And if you do decide to stick with Miller’s Money Forever, it’s still less expensive than a lifelong Ambien prescription. As the EBRI survey pointed out, in 2005 40% of those surveyed said they were “very comfortable.” By 2012 the number had dropped to 21%. Our goal at Miller’s Money Forever is to make sure our subscribers all fall into the 21% who are “very comfortable.”On the Lighter Side I saw that Danica Patrick won the pole position for the Daytona 500. I suspect that will add a few million viewers to the race next week. While she was born in Beloit, Wisconsin, she grew up in Roscoe, Illinois, right across the state line. We have friends who lived there, and she is certainly a hometown hero. Our Florida weather has been a bit cool over the last few days; the forecast for the race day is in the low 70s. Let’s hope it’s a good and safe race. —- My friend Rob – of We Buy Gold fame – and I went to a coin show over the weekend. There was no junk silver to be found, and Silver Eagles were also in short supply. After speaking with several dealers, they felt the current downturn in the price of metals will be short lived. And finally… Our friends Ed and Sarah sent us some clever puns. When the smog lifts in Los Angeles … U.C.L.A.  The batteries were given out … free of charge.  A dentist and a manicurist married … They fought tooth and nail. The percentage of workers expecting to retire before age 65 has decreased from 50% in 1991 to 24% in 2012.last_img read more

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Study 5000 Is the SelfDriving Car Sweet Spot

first_img 2 min read Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Tom Brant This story originally appeared on PCMag Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. An academic study suggests people are willing to pay just around $5,000 more for fully autonomous cars than typical vehicles. Add to Queue Study: $5,000 Is the Self-Driving Car Sweet Spot Sometimes it’s tough to make sense of the hodgepodge of technologies that currently describe the “self-driving car” buzzword, from lane departure warning systems all the way up to Tesla Autopilot, not to mention industry jargon like “Level 5 automation.”So why not organize autonomous driving technologies by how much people think they’re worth? That’s what a group of economists and engineers tried to do in a paper published in March, CNET reports. The model suggests that on average, Americans are willing to pay a $3,500 premium for a partially automated car and a $4,900 premium for a fully automated one. For comparison, $4,900 for full automation is very similar to what Tesla charges for its most advanced Autopilot, which costs a little over $5,000.The researchers’ model is based on interviews with 27 potential car buyers in New York City and upstate New York. As you might expect, just four of the New York City residents drove a car every day, while all of the 15 upstate New Yorkers commuted via car daily. The two groups perceived similar benefits from self-driving cars, from increased productivity and safety to easier and quicker parking.After crunching the numbers, the researchers found a fairly even segmentation of the demand for automation: about one-third of people are keenly interested and willing to pay $10,000 or more for self-driving features, one-third are ambivalent and the remainder isn’t willing to pay for automation at any price.As the researchers note, however, one of the key problems with such a study is that it’s based on a hypothetical purchase scenario: their study participants weren’t actually buying a car, and even if they were, there are very few models on the market that come with full automation on the level of the Tesla Autopilot.Still, it’s good to establish a peer-reviewed benchmark for how much self-driving tech should cost at this early stage in its development. If it follows the cheapening pattern of most other technology (and the government continues to urge its inclusion in new cars), you might one day be able to do yoga in your Toyota Corolla on the highway for far less than $5,000.center_img May 10, 2017 –shares Self-Driving Cars Image credit: Tesla via PC Mag Next Article News reporter Register Now »last_img read more

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Download Entrepreneur Magazines App for Apple and Android

first_imgEntrepreneur Corporate Communications Download Entrepreneur Magazine’s App for Apple and Android 3 min read Next Article Free Webinar | July 31: Secrets to Running a Successful Family Business –shares Image credit: Entrepreneur Access the latest issues of Entrepreneur and enjoy the latest news, videos and how-to articles-in one place, on any of your Apple or Android devices, and on your own terms. Entrepreneur Media Corporate Communications Here at Entrepreneur, we are always seeking ways to make it easier for you to get the information you need to boost your business productivity. We know you’re busy—and reading and viewing the latest business advice, trends and tips should be a bright spot in your day.To improve your Entrepreneur experience, we are excited to announce the latest evolution of our mobile app. In one seamless experience, you’ll find an ongoing stream of the latest news, how-to articles, exclusive interviews and videos from Entrepreneur.com. If you’re a magazine subscriber, you can access the newest issue of Entrepreneur magazine, plus your favorite archived issues, in a new mobile-optimized display that auto adjusts across your devices.Download the Entrepreneur magazine app on your iOS or Android device and enjoy:More Content: View the latest news and videos including trending articles, exclusive interviews, infographics, and more from Entrepreneur.com. Plus, access the latest issues of Entrepreneur magazine.Interactive Features: Now use 3D Touch, Interactive Push Notifications and Save for Later, which allows you to save content and read it later offline on your preferred device (syncs user content across multiple devices) for efficient, practical reading.Easy Read, Optimized Display : Enjoy the same fluid reading experience found right here on our website, no matter what you’re reading (our magazine articles are no longer bound to a fixed PDF layout) or what you’re reading on (the presentation will auto adjust to the device and screen orientation).In short, you can now effortlessly enjoy our magazine and digital content—in one place, on any of your Apple or Android devices, and on your own terms.How Does This Work?Our improved app will retain the Entrepreneur magazine name and we will be phasing out the Entrepreneur Daily app. Here’s how you get it:If you use the Entrepreneur Magazine app on iOS or Android: You don’t need to do anything. Depending on your settings, the app update will automatically update on your device or you may be required to activate the update. That’s it!If you use the Entrepreneur Daily app on IOS: You will need to download the new Entrepreneur magazine app. If you use the Entrepreneur Daily app on Android: You will need to download the new Entrepreneur magazine app. Note: While you will have still access to all our great digital-only content, the full digital magazine articles is only available to subscribers. You can easily upgrade within the app.Thank you for your past and continued readership. We look forward to bringing you the business productivity content you need in an easy-to-read format you’ll enjoy.Download the Entrepreneur magazine app on your iOS or Android device now. Add to Queue Register Now » May 26, 2017 Learn how to successfully navigate family business dynamics and build businesses that excel. Opinions expressed by Entrepreneur contributors are their own.last_img read more

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What to Expect at Apple WWDC 2017

first_imgApple This story originally appeared on PCMag 2019 Entrepreneur 360 List June 5, 2017 The only list that measures privately-held company performance across multiple dimensions—not just revenue. Add to Queue Apple’s annual Worldwide Developer Conference (WWDC) kicks off Monday in San Jose, where we expect to hear about the new versions of iOS and MacOS, and perhaps One More Thing.We’ll have hands-on coverage from the event floor that day, but for now, here are some of the most prominent rumors and likely announcements making the rounds in the lead up to the keynote.iOS 11 and MacOS 10.13The only true surefire bets for WWDC are new versions of Apple’s mobile and computer software platforms. Most Apple consumers will end up with some or all of the announced features depending on which products they use, and developers are eager to hear what they’ll have to work with, so these will be the stars of the show.Expect the usual updates to core apps like Safari and Mail, with productivity enhancements across the board. Exact feature additions will read more like a wish list since little is known or confirmed currently, but maybe we’ll see announcements like conference calls in FaceTime.Improvements for watchOS and tvOS should also be on display, mainly in the form of more integration into the two main platforms. Increased Siri functionality and unification across the platform might play a big part in the conference, too, especially if the next rumor turns out to be true.Siri speakerApple’s answer to Alexa (and more recently, Google Home) has been long expected, and it seems like this could be the year we finally see one.Whether this is something consumers are itching for remains to be seen — no doubt many interested in a voice assistant have given in and purchased an Amazon Echo or Google Home by now, but the Apple ecosystem could be enough of an incentive to buy. Either way, Bloomberg reports that a Siri speaker has already entered production, so there’s a good chance we see it on Monday.That said, Apple could wait to debut the speaker later in the year, which would be closer to its expected shipping date. If reports are true, it will differentiate itself from the Echo and Google Home with features like virtual surround and, as mentioned, integration with the already ubiquitous lineup of Apple products in millions of homes.MacBook and MacBook Pro refreshesThe standard MacBook and MacBook Pro lines were given some love in 2016 with modest redesigns and, in the case of the Pro, the introduction of the Touch Bar. As such, any announcements about these two lines at WWDC will likely include minor component updates, such as the latest generation Intel processors, rather than major physical or feature changes.There have been some industry rumblings to support this speculation, but it may turn out this traditionally software-focused event saves its MacBook overhaul for a product that might need it a little more attention.New MacBook Air?The Air remains an all-time favorite laptop for many, despite Apple’s relatively infrequent updates to the line. It’s appealing as the cheapest (comparatively) entry in Apple’s laptop line, and did not receive the 2016 refresh its counterparts did. An “if it ain’t broke, don’t fix it” approach makes some sense here, but the most recent MacBook Air was released in 2015, and if Apple skips another upgrade, 2018 is an awfully long wait in computer time.If it does arrive, expect a USB-C only approach, since even the “thicker” 2016 MacBook dropped the larger standard USB ports. The 1,440-by-900-display resolution would almost definitely receive a boost, since it was already on the low side in 2015, and its great battery life may very well creep even closer to 20 hours.Refined iPad ProIf the existing 9.7- and 12.9-inch iPad Pro models don’t do it for you, how does something in the middle sound? Thanks in part to analyst expectations (as reported by Mac Rumors), there’s plenty of buzz suggesting a 10.5-inch iPad Pro will be revealed at WWDC that similar in size to the 9.7-inch model.The extra screen space will be made possible by much thinner bezels — nearly edge-to-edge — so that Apple can fit a larger screen in a smaller body. In fact, it may replace the 9.7-inch version altogether, since it’s essentially the same size with a bigger display. Odds are this won’t be the only upgrade: The usual component updates like better cameras, a new processor, and maybe a new Apple Pencil would fill out the rest of this announcement. Apply Now » Matthew Buzzicenter_img Next Article Check out the most prominent rumors and speculation about WWDC ahead of Monday’s keynote. Writer Image credit: via PC Mag 4 min read What to Expect at Apple WWDC 2017 –shareslast_img read more

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Facebook May Take Extra Steps to Remove AntiVaccine Misinformation

first_img Facebook is “exploring additional measures” to fight anti-vaccine disinformation, according to Bloomberg. Content discouraging parents from vaccinating their children has been rampant on the site, particularly in Facebook Groups, and may have contributed to a measles outbreak in Washington State. That caught the attention of U.S. Representative Adam Schiff, who wrote a letter to Facebook and Google asking them to address the problem.Schiff noted that Facebook is surfacing and recommending messages that may pose a threat to public health. For instance, the Guardian recently reported that Facebook was accepting and promoting ads from anti-vax groups. “Repetition of information, even if false, can often be mistaken for accuracy,” he wrote. “The algorithms which power these services are not designed to distinguish quality information from misinformation.”Facebook said that it’s “exploring additional measures to best combat the problem,” including “reducing or removing this type of content from recommendations, including ‘Groups You Should Join,’ and demoting it in search results, while also ensuring that higher quality and more authoritative information is available.”The resurgence of measles is of serious concern, with extended outbreaks occurring across regions, and particularly in countries that had achieved, or were close to achieving measles elimination.Google recently said YouTube would restrict video recommendations that “could misinform users in harmful ways,” including anti-vaccine videos. It also said recently that would provide links alongside videos on “historical and scientific topics that have often been subject to misinformation.” Until recently, anti-vax videos topped results for “vaccine” searches, but the top results now appear to be from sites like Last Week Tonight attempting to dispel vaccination myths. However, Robert F. Kennedy’s widely debunked anti-vax documentary is still in the top 10.The CDC notes that vaccines have been proven safe and effective and only result in minor side effects. However, avoiding them can put not just your own children but others at risk, particularly small babies who have yet to be inoculated. “Without urgent efforts to increase vaccination coverage … we risk losing decades of progress in protecting children and communities,” said Unicef’s Dr. Soumya Swaminathan. Add to Queue 2 min read Next Article Register Now » –shares Image credit: Fred Tanneau | Getty Images via engadget Facebook Steve Dent February 15, 2019 Facebook May Take Extra Steps to Remove Anti-Vaccine Misinformation Learn how to successfully navigate family business dynamics and build businesses that excel. This story originally appeared on Engadget Conspiracy theories on the site may have contributed to a measles outbreak. Free Webinar | July 31: Secrets to Running a Successful Family Businesslast_img read more

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Consumer Reports Drops Its Tesla Recommendation

first_img Consumer Reports said it would no longer recommend Tesla’s Model S sedan due to reliability concerns, in a blow to the luxury electric-powered car initially awarded the highest-ever score in the U.S. magazine’s performance ratings.The decision, based on the influential publication’s annual survey of vehicle reliability, sent shares of Tesla Motors Inc reeling and underscored the risk of introducing cutting-edge fuel-saving technology and digital multimedia systems in vehicles.Consumer Reports found “an emerging trend of increased troubles” with a broad range of vehicles that use new transmission technology to boost mileage. The survey was presented by the magazine’s editors at a meeting of Detroit’s Automotive Press Association on Tuesday.The findings illustrate automakers’ challenges as consumers and regulators demand more innovation. Groundbreaking technology comes with a heightened risk of malfunctions over the life of a vehicle, compromising the reliability car owners enjoy from more mature technology.Tesla’s stock fell as much as 11.4 percent before closing down 6.6 percent to $213.03 after the magazine said Tesla owners reported “an array of detailed and complicated maladies” in their Model S sedans.Still, 97 percent of Tesla owners would buy another Model S, the magazine found, citing quick responsiveness on repairs from the Palo Alto-based company “with a minimum of fuss to owners.”One of the most technologically adventurous cars on the market, the Model S registered a worse than average reliability score based on survey responses from 1,400 owners.The battery-powered Model S P85D was lauded in August for racking up the best scores ever in the magazine’s performance tests. But owners complained of rattles, leaks, and problems with the charging equipment, drivetrain and center console displays, Consumer Reports said.”Close communication with our customers enables Tesla to receive input, proactively address issues, and quickly fix problems,” a Tesla spokesperson said. “Over-the-air software updates allow Tesla to diagnose and fix most bugs without the need to come in for service. In instances when hardware needs to be fixed, we strive to make it painless.”Complaints about balky multimedia infotainment systems continue to plague several major automakers, including Ford Motor Co, Nissan Motor Co, Fiat Chrysler Automobiles NV and General Motors Co, the magazine found.Honda Motor Co’s Acura luxury brand fell seven places to No. 18 in the magazine’s ranking of 28 brands because of problems with transmissions and in-car entertainment systems.Overall, Toyota Motor Corp’s Lexus brand was the top-ranked brand in the magazine’s reliability survey. The highest-ranked Detroit brand was GM’s Buick, at No. 7.Fiat Chrysler Automobiles NV’s Fiat brand came in last.(Additional reporting and writing by Alexandria Sage; editing by Bernard Orr, Christian Plumb and Phil Berlowitz) October 21, 2015 Reuters Tesla Next Article Image credit: Olivier Le Queinec / Shutterstock.com Add to Queue The only list that measures privately-held company performance across multiple dimensions—not just revenue.center_img Consumer Reports Drops Its Tesla Recommendation This story originally appeared on Reuters Apply Now » 2019 Entrepreneur 360 List –shares 3 min readlast_img read more

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Demystifying Predictive Analytics

first_imgDemystifying Predictive Analytics Jamie SchisslerApril 26, 2019, 4:00 pmJuly 22, 2019 What if you had a crystal ball that could tell you which leads are sales-ready and which need some nurturing? Or what type of content will most engage a specific visitor; which customers are most likely to purchase which products and through which channel; or how much demand will increase during peak holiday time?This is predictive analytics: The statistical analysis and identification of attributes that have a direct correlation to a future event or condition. There’s been so much hype about predictive analytics recently that it’s easy to forget it’s been around for over 50 years — from weather forecasting and flight planning to consumer credit scoring and fraud detection. From a marketing perspective, the accuracy it provides and the predictive opportunities it creates can substantially minimize risk while driving tremendous efficiency and performance gains.  What is new is the availability of predictive analytics. Once the luxury and secret sauce for only the largest brands staffed with deep data and analytics teams, expertise, and infrastructure, PA is available to organizations and business of all sizes.So, how can marketers drive adoption, establish predictive analytics competency, and use it to create better outcomes for businesses and experiences for customers? Let’s break down some of the basics. Recognize the power of segmentationTraditional marketing segmentation is about grouping audiences by historical attributes like age, gender, geography, etc. The emphasis of this approach is on understanding what individual consumers have done in the past and/or who they are at this moment in order to better focus and calibrate the brand’s sales and marketing efforts.Predictive analytics can also be thought of as a segmentation strategy. The difference is it employs algorithmic models against much of the same underlying data in order to identify and group customers by what they are likely to do or prefer. As such, it’s useful to think of and approach predictive analytics as a segmentation strategy to identify customers by future behavior, such as those who are likely to travel soon, renew a lease, upgrade, or refer a friend.Read More: How AI will Change the Game for Influencer MarketingDefine specific business cases and develop effective strategiesThinking of it as a segmentation strategy, it’s helpful to begin by defining those groups that represent the greatest opportunities or needs for your business. Perhaps your primary goal is lead velocity. Or maybe it’s churn reduction or lifetime value. Focus on one or two to start, otherwise, you’ll get overwhelmed quickly.After you’ve defined your business and use cases, you’ll need to develop a strategy for how you are going to engage that audience. It’s one thing to be able to identify customers who are likely to do something. It’s another to figure out what that means for your business and how you are going to act on it. Both elements – identification and treatment strategy — are essential.Identify the right data Before rolling up your sleeves and diving into the data science and algorithms, identify the data required for your model. In some cases, you may find you simply don’t have the attributes or volume to create the segment with the degree of probability required. Focus on what you can do with the data you currently have, while simultaneously working on a longer-term roadmap and action plan, complete with business cases.Read More: 3 Ways Mobile Technology is Changing the Brick-and-Mortar ExperiencePrioritize consumer trust and respectA few years ago a Target employee infamously used individual purchase data to build a model that would predict, with tremendous accuracy, which of its customers was likely pregnant. The audience was then subtly targeted with specific relevant products via direct mail. This example provides several important lessons when embarking upon predictive analytics. It underscores the potency and accuracy of predictive analytics while demonstrating that it doesn’t take a huge staff to develop and implement (though it does require a lot of data). More importantly, it demonstrates that in all things, trust and respect matter. The creep factor, invasiveness, and breach of privacy and trust in this application was a bridge too far.To avoid such pitfalls, marketers should ensure there is governance and oversight in how predictive segments are defined and utilized. Socialize internally the segments the organization seeks to create and why, balancing out the needs of the business with customer preference, perception, privacy, and experience.The power of predictive analyticsThe predictive analytics landscape is an incredible opportunity to streamline the customer journey, deliver better experiences and value to your audiences, and boost overall business performance. Brands such as Netflix, through its recommendation engine, and Marriott are using PA to deliver messages at key decision points. Marriott uses it for better insight on the types of travelers likely to stay at their properties; for insight on and understanding of what attracts travelers to it over other brands; and to better understand the unique travel patterns and needs of those who travel for business versus those who travel for pleasure.What’s really exciting is not just what brands can do with PA, but that the variety of PA technologies and solutions available today make it accessible to every organization. Plan carefully and deliberately, advance incrementally, and implement governance that reflects your organizational values and goals and you’ll be on your way to delivering exceptional customer experiences and accelerating growth.Read More: Eye Rolls at Pre-Rolls: How to Escape the Trap of Annoying Ads customer experienceMarketing TechnologyMarriottNetflixpredictive analytics Previous ArticleWhy Senior Business Leaders Should Care About CX DataNext ArticleWhy Measurement is the Secret to Agency Successlast_img read more

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Home blood pressure measurements can be used to diagnose hypertension in US

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 29 2018Blood pressure readings of 130/80 millimeters of mercury (mm Hg) or higher taken at home can be used to diagnose hypertension in white, black and Hispanic U.S. adults, according to new research in the American Heart Association’s journal Hypertension.”Until now, recommendations for diagnosing high blood pressure with measurements done at home were primarily from Japanese and European studies,” said Wanpen Vongpatanasin, M.D., study author, professor of medicine and hypertension director at UT Southwestern Medical Center in Dallas. “We didn’t know if these recommendations actually applied to U.S. adults.”Researchers analyzed large multi-ethnic studies that compared home blood pressure to clinic measurements of primarily young and middle-aged adults in Dallas, Texas and Durham, North Carolina. In 420 participants in the North Carolina clinic, high blood pressure readings (130/80) were confirmed with similar readings at home. In 3,132 participants in the Dallas study, researchers determined risks of stroke, heart attack and death associated with a clinic systolic blood pressure reading of 130 mm Hg. During the 11-year follow up, researchers also determined that people with high blood pressure levels measured at home had the same heart disease risk as people with similar levels measured by medical professionals.Related StoriesBlood pressure self-monitoring can help patients with hypertension to stick with exercise programMathematical model helps quantify metastatic cell behaviorDon’t ignore diastolic blood pressure values, say researchersVongpatanasin added that the findings correlate with the American Heart Association/American College of Cardiology 2017 blood pressure guideline.”It’s important to measure blood pressure at home because clinic readings might not reflect a person’s true blood pressure. Some people have higher readings in the clinic because of the ‘white coat’ phenomenon, while studies have shown that others – especially, blacks – have lower blood pressure readings in the clinic than at home,” she said.This study included adults aged 30 to 65 years old from two U.S. cities, so the findings might not apply to younger or older people or adults in different geographical areas, she said.With the definition of high blood pressure set at 130/80 mm Hg, nearly half (46 percent) of U.S. adults have high blood pressure. Researchers have found that at least 30 percent to 45 percent of U.S. adults with hypertension monitor their blood pressure at home.The American Heart Association recommends consumers follow the proper technique when measuring blood pressure: be still and rest quietly for at least 5 minutes before measurements; avoid caffeine or cigarettes in the half hour before your reading; keep both feet flat on the floor; and avoid talking during the test. At least two readings should be taken one minute apart in the morning before taking medications and in the evening before eating. Ideally, blood pressure readings should be taken during one week beginning a few weeks after a change in the treatment regimen and during the week before a doctor’s visit. Source:https://newsroom.heart.org/news/home-monitoring-confirms-clinic-diagnosis-of-high-blood-pressure?preview=3656last_img read more

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Antiinflammatory biologic therapy may prevent heart disease in patients with skin condition

first_img Source:https://www.escardio.org/ Reviewed by James Ives, M.Psych. (Editor)Feb 5 2019Anti-inflammatory biologic drugs used to treat severe psoriasis have the potential to prevent heart disease in patients with the skin condition, according to research published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC). During one year of treatment, biologic therapy improved coronary artery plaque similar to the effect of a low-dose statin.”Psoriasis severity is related to the burden of coronary disease – our findings suggest treating the psoriasis may potentially benefit coronary heart disease,” said study author Dr Nehal Mehta, Chief of Inflammation and Cardiometabolic Diseases at the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, US.Psoriasis causes scaly skin patches, often on the elbows, knees, scalp, and lower back. Patients with the skin condition have an elevated risk of heart disease – young patients with severe psoriasis are at twice the risk of having a first heart attack at 40-50 years of age.Psoriasis patients often have inflammation throughout the body and may be treated with anti-inflammatory biologic therapy when their skin condition is severe and topical treatments or phototherapy have failed. This study investigated whether treating severe psoriasis with a biologic could improve the health of the coronary arteries.The study found that patients with severe psoriasis who took biologic therapy for one year had an 8% reduction in total and non-calcified coronary plaque burden, a frequent cause of heart attacks (see figure) – similar to the effect of a low dose statin. The make-up of coronary plaques also improved in those taking biologics, making them less risky. Coronary plaque burden increased by 2% in patients who did not take a biologic.Dr Mehta said: “We found that these anti-inflammatory drugs commonly used to treat severe psoriasis also improve plaque in the coronary artery making them more stable and less likely to cause a heart attack. This occurred in the absence of changes in traditional cardiovascular risk factors including blood pressure and blood lipids.”Related StoriesStroke should be treated 15 minutes earlier to save lives, study suggestsCutting around 300 calories a day protects the heart even in svelte adultsCancer incidence among children and young adults with congenital heart diseaseDuring the one-year study, systemic inflammation assessed by blood markers reduced only in the group taking biologic therapy. Dr Mehta said it is too early to say whether biologics exert their effects on coronary plaques directly or by reducing systemic inflammation.He said: “This preliminary study provides the first evidence that biologic therapy is associated with coronary plaque reduction and stabilization, and provides strong rationale for conduct of a randomized trial testing the impact of biologic therapy on the progression of coronary disease in patients with psoriasis.”Dr Mehta noted that some patients with severe psoriasis opt not to take a biologic medicine because they suppress the immune system and may increase the chance of infection. In addition, they must be injected.Previous research has shown that in heart attack patients, anti-inflammatory biologic therapy reduces the risk of another cardiovascular event.2 “With the results of that study and our current one, my message to patients with psoriasis is to take untreated inflammation seriously,” said Dr Mehta. “When someone has severe psoriasis, they are at higher risk of heart attack and treating the psoriasis may reduce that risk.”The observational study included 121 patients with severe psoriasis who qualified for biologic treatment. Of those, 89 took biological therapy (one of three types) and 32 used topical treatment. All patients underwent imaging of their coronary arteries with computed tomography angiography at baseline and one year later to assess the amount and characteristics of plaques such as the necrotic core which causes plaque rupture.last_img read more

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Early genome catastrophes can lead to development of lung cancer in nonsmokers

first_imgThe research team plans to further focus on the molecular mechanisms that stimulate complex rearrangements in the body, through screening the genomic structures of fusion genes in other cancer types.Source:The Korea Advanced Institute of Science and Technology (KAIST)Journal reference:Kim, Y.T. et al. (2019) Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma. Cell. doi.org/10.1016/j.cell.2019.05.013. We hope this work will help us get one step closer to precision medicine for lung cancer patients.” Reviewed by Alina Shrourou, B.Sc. (Editor)May 31 2019Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related lung cancers develop.Researchers at KAIST, Seoul National University and their collaborators confirmed that gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and on average about three decades before cancer is diagnosed. The study showed that these mutant lung cells, harboring oncogenic seeds, remain dormant for several decades until a number of further mutations accumulate sufficiently for progression into cancer. This is the first study to reveal the landscape of genome structural variations in lung adenocarcinoma.Lung cancer is the leading cause of cancer-related deaths worldwide, and lung adenocarcinoma is its most common type. Most lung adenocarcinomas are associated with chronic smoking, but about a fourth develop in non-smokers. Precisely what happens in non-smokers for this cancer to develop is not clearly understood.Researchers analyzed the genomes of 138 lung adenocarcinoma patients, including smokers and non-smokers, with whole-genome sequencing technologies. They explored DNA damage that induced neoplastic transformation.Lung adenocarcinomas that originated from chronic smoking, referred to as signature 4-high (S4-high) cancers in the study, showed several distinguishing features compared to smoking-unrelated cancers (S4-low).People in the S4-high group were largely older, men and had more frequent mutations in a cancer-related gene called KRAS. Cancer genomes in the S4-high group were hypermutated with simple mutational classes, such as the substitution, insertion, or deletion of a single base, the building block of DNA.But the story was very different in the S4-low group. Generally, mutational profiles in this group were much more silent than the S4-high group. However, all cancer-related gene fusions, which are abnormally activated from the merging of two originally separate genes, were exclusively observed in the S4-low group.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSpecial blood test may predict relapse risk for breast cancer patientsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe patterns of genomic structural changes underlying gene fusions suggest that about three in four cases of gene fusions emerged from a single cellular crisis causing massive genomic fragmentation and subsequent imprecise repair in normal lung epithelium.Most strikingly, these major genomic rearrangements, which led to the development of lung adenocarcinoma, are very likely to be acquired decades before cancer diagnosis. The researchers used genomic archaeology techniques to trace the timing of when the catastrophes took place.Researchers started this study seven years ago when they discovered the expression of the KIF5B-RET gene fusion in lung adenocarcinoma for the first time. Professor Young-Seok Ju, co-lead author from the Graduate School of Medical Science and Engineering at KAIST says, “It is remarkable that oncogenesis can begin by a massive shattering of chromosomes early in life. Our study immediately raises a new question: What induces the mutational catastrophe in our normal lung epithelium.”Professor Young Tae Kim, co-lead author from Seoul National University says:last_img read more

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Dyson switches HQ from Britain to Singapore company

first_imgBritish electric appliance pioneer Dyson will switch headquarters to Singapore this year due to booming Asian demand but not because of Brexit, the company said Tuesday. © 2019 AFP The group, founded and owned by serial entrepreneur and vocal Brexit supporter James Dyson, last year announced it would produce electric cars in Singapore.The firm stressed that Brexit was not a factor behind the decision to ditch its corporate base in Malmesbury in Wiltshire, western England, in favour of Singapore.Dyson, famed for its cordless vacuum cleaners, hand dryers and fans, now has its sights set on electric vehicles—particularly in Asia.”An increasing majority of Dyson’s customers and all of our manufacturing operations are now in Asia; this shift has been occurring for some time and will quicken as Dyson brings its electrical vehicle to market,” it said in an earnings statement.”As a result, an increasing proportion of Dyson’s executive team is going to be based in Singapore; positioning them to make the right decisions for Dyson in a quick and efficient way.”This does not change any of our investment and recruitment plans; however we are now at a point where Dyson’s corporate head office will relocate there to reflect the increasing importance of Asia to Dyson’s business.”A prototype Dyson electric vehicle is in the works for 2020, followed by a product launch in 2021.’Not related to Brexit’The Singapore move “is not related to Brexit”, chief executive Jim Rowan told reporters on a conference call, noting there was only a “negligible” tax benefit.”We don’t see any issues regarding Brexit,” he said, adding that Dyson’s manufacturing capacity, as well as the majority of its supply base, is in south east Asia.”We are a global technology company,” Rowan insisted, adding that it would continue to invest in home market Britain.Dyson had already announced last October that it had picked Singapore for its first electric car plant, sparking criticism from some quarters that its Brexit-backing billionaire founder had not invested more in the UK.But the group also said in March that it would open a second research and development centre in a former Royal Air Force airfield in Hullavington, southwest England.Meanwhile on Tuesday, Dyson said that 2018 underlying profit—as measured by earnings before interest, taxes, depreciation and amortisation (EBITDA)—surged one third to £1.1 billion (1.2 billion euros, $1.4 billion).Turnover, or sales, rose by 28 percent to stand at £4.4 billion on growing global appetite for cutting-edge technology.”Globally, enthusiastic owners are demanding high-performance products so we are deepening out operations and technology investments to meet their needs,” added Rowan.James Dyson, who owns 100 percent of the company he founded in the 1970s, has revolutionised household appliances with his bagless vacuum cleaners, bladeless fans and air purifiers. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Citation: Dyson switches HQ from Britain to Singapore: company (2019, January 22) retrieved 17 July 2019 from https://phys.org/news/2019-01-dyson-hq-britain-singapore-company.html Leaving Britain, but not because of Brexit Dyson shifts up a gear with electric car hublast_img read more

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Occupy Tanjung Aru beach picnic is on tomorrow

first_imgKOTA KINABALU: At least a thousand people are expected to turn up for a “picnic” along the Tanjung Aru beach, where a controversial development plan is meeting opposition from non-governmental groups. The Occupy @ Tanjung Aru picnic tomorrow is organised by the Save Open Space Kota Kinabalu (SOS KK) group which previously started an online petition to stop the Tanjung Aru Eco-Development (Taed) project.SOS KK coordinator S.M. Muthu said the informal gathering – aimed at pooling like-minded people to show solidarity in saving the beach – was expected to be the first in a series of activities it was planning to engage the public. “We are trying to gauge the response. Nation 28 Jun 2019 NGO signature drive on to stop TAED project, calls for meeting with Sabah CM Related News Nation 20h ago NGO plans Occupy @ Tanjung Aru picnic to ‘save’ iconic beach Nation 26 Jun 2019 SAPP: Sabah govt statements about Papar dam, TAED ‘huge disappointment’center_img “It is just a picnic. No one will be talking. In the future, we may need a permit if we get individuals to speak,” he said when contacted.The project was mooted during the previous Barisan Nasional administration, and the then Opposition had campaigned against it during the last general election. However, the Parti Warisan Sabah-led state government decided later to stick with the project but promised that it would be a win-win situation with an area for the public. An invitation to Sabahans to join the event at Prince Phillip Park, along Tanjung Aru beach, was shared via the change.org online platform. The picnic is expected to take place between 4pm and sunset. “Wear yellow or green, bring your own F&B (food and beverage), and make it a Zero Waste event,” said the notice.On the online petition, Muthu said over 28,000 pledges had been collected so far. “We initially wanted to arrange for a meeting with the Sabah Chief Minister but that was unlikely considering how things went.“So, we will send the petition to his office after we hit the 30,000-signature mark, maybe some time next week. Then, it is up to them (to consider),” he said. {{category}} {{time}} {{title}} Related Newslast_img read more

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