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Humanoriented perspective needed to better understand Parkinsons disease

first_imgReviewed by James Ives, M.Psych. (Editor)Sep 25 2018Analysis published in Drug Discovery Today reveals the gap between animal models of Parkinson’s disease (PD) and our understanding of the neurodegenerative processes underlying the disease, and calls for the implementation of modern, human biology-based technologies to better understand pathological processes and improve treatment outcome.While current approaches to drug discovery for PD have led to the development of tools for the motor symptoms that accompany neurodegeneration, they have fallen short of identifying preventative or curative therapies. The authors of “Parkinson’s disease research: adopting a more human perspective to accelerate advances” describe how this failure derives from the fact that animal disease models can never fully replicate the healthy or diseased human brain. Dr. Catherine Willett and Dr Lindsay Marshall advocate new approaches with greater focus on recent advances in systems biology computer science and engineering using information from human cells, tissues, and subjects.Dr. Willett, senior director of science and regulatory affairs at the Humane Society of the United States and Humane Society International, explained that “no animal model can fully recapitulate the complex multisystem pathology that underlies the clinical signs and symptoms of human PD. Rather, animal models typically reproduce specific pathological components but fail to account for the complete biology underlying the disease. Animal models therefore have limited capacity to reveal the true causes of, or identify real cures for, human Parkinson’s.”Rather than using limited research funds for creating more animal models or for modifying existing animal models, Dr Willett describes what is needed to better understand PD: “To definitively understand and treat Parkinson’s and other uniquely human neurodegenerative disorders, new approaches need to focus directly on human systems per se. Human-specific PD characteristics can be examined using human cell cultures, human stem-cell derived tissues, computer modeling, and new imaging modalities.”Related StoriesNovel device could enable early diagnosis and treatment development for Parkinson’s diseaseStudy reveals vitamin B12 as inhibitor of key enzyme in hereditary Parkinson’s diseaseGut infection can lead to a pathology resembling Parkinson’s diseaseEven though some animal models have provided valuable insight into PD’s pathophysiology, there has been no substantial progress in the development of new therapeutic treatments targeting the degenerative mechanisms underlying the disease. One of the major reasons for this is that by the time a patient displays PD symptoms, degeneration is already advanced, shifting the focus to symptomatic treatment. In addition, as increasingly demonstrated over the past decade, there are many difficulties in translating findings from animals to humans which lead to high failure rates and often catastrophic results, such as those seen with treatments for inflammation, hepatitis B and schizophrenia. With PD affecting 1-2% of the population over 65 years of age and a growing ageing population globally, the paper calls for investment in modern, human-based technology to address the poor translation of animal models from bench to clinic when devising solutions for PD. A concerted effort to approach PD from a systems biology, pathway-based, collaborative, human-oriented perspective could provide a foundation for innovative ways to analyze health and disease more generally. Source:http://www.hsi.org/last_img read more

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Home blood pressure measurements can be used to diagnose hypertension in US

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 29 2018Blood pressure readings of 130/80 millimeters of mercury (mm Hg) or higher taken at home can be used to diagnose hypertension in white, black and Hispanic U.S. adults, according to new research in the American Heart Association’s journal Hypertension.”Until now, recommendations for diagnosing high blood pressure with measurements done at home were primarily from Japanese and European studies,” said Wanpen Vongpatanasin, M.D., study author, professor of medicine and hypertension director at UT Southwestern Medical Center in Dallas. “We didn’t know if these recommendations actually applied to U.S. adults.”Researchers analyzed large multi-ethnic studies that compared home blood pressure to clinic measurements of primarily young and middle-aged adults in Dallas, Texas and Durham, North Carolina. In 420 participants in the North Carolina clinic, high blood pressure readings (130/80) were confirmed with similar readings at home. In 3,132 participants in the Dallas study, researchers determined risks of stroke, heart attack and death associated with a clinic systolic blood pressure reading of 130 mm Hg. During the 11-year follow up, researchers also determined that people with high blood pressure levels measured at home had the same heart disease risk as people with similar levels measured by medical professionals.Related StoriesBlood pressure self-monitoring can help patients with hypertension to stick with exercise programMathematical model helps quantify metastatic cell behaviorDon’t ignore diastolic blood pressure values, say researchersVongpatanasin added that the findings correlate with the American Heart Association/American College of Cardiology 2017 blood pressure guideline.”It’s important to measure blood pressure at home because clinic readings might not reflect a person’s true blood pressure. Some people have higher readings in the clinic because of the ‘white coat’ phenomenon, while studies have shown that others – especially, blacks – have lower blood pressure readings in the clinic than at home,” she said.This study included adults aged 30 to 65 years old from two U.S. cities, so the findings might not apply to younger or older people or adults in different geographical areas, she said.With the definition of high blood pressure set at 130/80 mm Hg, nearly half (46 percent) of U.S. adults have high blood pressure. Researchers have found that at least 30 percent to 45 percent of U.S. adults with hypertension monitor their blood pressure at home.The American Heart Association recommends consumers follow the proper technique when measuring blood pressure: be still and rest quietly for at least 5 minutes before measurements; avoid caffeine or cigarettes in the half hour before your reading; keep both feet flat on the floor; and avoid talking during the test. At least two readings should be taken one minute apart in the morning before taking medications and in the evening before eating. Ideally, blood pressure readings should be taken during one week beginning a few weeks after a change in the treatment regimen and during the week before a doctor’s visit. Source:https://newsroom.heart.org/news/home-monitoring-confirms-clinic-diagnosis-of-high-blood-pressure?preview=3656last_img read more

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Antiinflammatory biologic therapy may prevent heart disease in patients with skin condition

first_img Source:https://www.escardio.org/ Reviewed by James Ives, M.Psych. (Editor)Feb 5 2019Anti-inflammatory biologic drugs used to treat severe psoriasis have the potential to prevent heart disease in patients with the skin condition, according to research published today in Cardiovascular Research, a journal of the European Society of Cardiology (ESC). During one year of treatment, biologic therapy improved coronary artery plaque similar to the effect of a low-dose statin.”Psoriasis severity is related to the burden of coronary disease – our findings suggest treating the psoriasis may potentially benefit coronary heart disease,” said study author Dr Nehal Mehta, Chief of Inflammation and Cardiometabolic Diseases at the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, US.Psoriasis causes scaly skin patches, often on the elbows, knees, scalp, and lower back. Patients with the skin condition have an elevated risk of heart disease – young patients with severe psoriasis are at twice the risk of having a first heart attack at 40-50 years of age.Psoriasis patients often have inflammation throughout the body and may be treated with anti-inflammatory biologic therapy when their skin condition is severe and topical treatments or phototherapy have failed. This study investigated whether treating severe psoriasis with a biologic could improve the health of the coronary arteries.The study found that patients with severe psoriasis who took biologic therapy for one year had an 8% reduction in total and non-calcified coronary plaque burden, a frequent cause of heart attacks (see figure) – similar to the effect of a low dose statin. The make-up of coronary plaques also improved in those taking biologics, making them less risky. Coronary plaque burden increased by 2% in patients who did not take a biologic.Dr Mehta said: “We found that these anti-inflammatory drugs commonly used to treat severe psoriasis also improve plaque in the coronary artery making them more stable and less likely to cause a heart attack. This occurred in the absence of changes in traditional cardiovascular risk factors including blood pressure and blood lipids.”Related StoriesStroke should be treated 15 minutes earlier to save lives, study suggestsCutting around 300 calories a day protects the heart even in svelte adultsCancer incidence among children and young adults with congenital heart diseaseDuring the one-year study, systemic inflammation assessed by blood markers reduced only in the group taking biologic therapy. Dr Mehta said it is too early to say whether biologics exert their effects on coronary plaques directly or by reducing systemic inflammation.He said: “This preliminary study provides the first evidence that biologic therapy is associated with coronary plaque reduction and stabilization, and provides strong rationale for conduct of a randomized trial testing the impact of biologic therapy on the progression of coronary disease in patients with psoriasis.”Dr Mehta noted that some patients with severe psoriasis opt not to take a biologic medicine because they suppress the immune system and may increase the chance of infection. In addition, they must be injected.Previous research has shown that in heart attack patients, anti-inflammatory biologic therapy reduces the risk of another cardiovascular event.2 “With the results of that study and our current one, my message to patients with psoriasis is to take untreated inflammation seriously,” said Dr Mehta. “When someone has severe psoriasis, they are at higher risk of heart attack and treating the psoriasis may reduce that risk.”The observational study included 121 patients with severe psoriasis who qualified for biologic treatment. Of those, 89 took biological therapy (one of three types) and 32 used topical treatment. All patients underwent imaging of their coronary arteries with computed tomography angiography at baseline and one year later to assess the amount and characteristics of plaques such as the necrotic core which causes plaque rupture.last_img read more

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Early genome catastrophes can lead to development of lung cancer in nonsmokers

first_imgThe research team plans to further focus on the molecular mechanisms that stimulate complex rearrangements in the body, through screening the genomic structures of fusion genes in other cancer types.Source:The Korea Advanced Institute of Science and Technology (KAIST)Journal reference:Kim, Y.T. et al. (2019) Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma. Cell. doi.org/10.1016/j.cell.2019.05.013. We hope this work will help us get one step closer to precision medicine for lung cancer patients.” Reviewed by Alina Shrourou, B.Sc. (Editor)May 31 2019Catastrophic rearrangements in the genome occurring as early as childhood and adolescence can lead to the development of lung cancer in later years in non-smokers. This finding, published in Cell, helps explain how some non-smoking-related lung cancers develop.Researchers at KAIST, Seoul National University and their collaborators confirmed that gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and on average about three decades before cancer is diagnosed. The study showed that these mutant lung cells, harboring oncogenic seeds, remain dormant for several decades until a number of further mutations accumulate sufficiently for progression into cancer. This is the first study to reveal the landscape of genome structural variations in lung adenocarcinoma.Lung cancer is the leading cause of cancer-related deaths worldwide, and lung adenocarcinoma is its most common type. Most lung adenocarcinomas are associated with chronic smoking, but about a fourth develop in non-smokers. Precisely what happens in non-smokers for this cancer to develop is not clearly understood.Researchers analyzed the genomes of 138 lung adenocarcinoma patients, including smokers and non-smokers, with whole-genome sequencing technologies. They explored DNA damage that induced neoplastic transformation.Lung adenocarcinomas that originated from chronic smoking, referred to as signature 4-high (S4-high) cancers in the study, showed several distinguishing features compared to smoking-unrelated cancers (S4-low).People in the S4-high group were largely older, men and had more frequent mutations in a cancer-related gene called KRAS. Cancer genomes in the S4-high group were hypermutated with simple mutational classes, such as the substitution, insertion, or deletion of a single base, the building block of DNA.But the story was very different in the S4-low group. Generally, mutational profiles in this group were much more silent than the S4-high group. However, all cancer-related gene fusions, which are abnormally activated from the merging of two originally separate genes, were exclusively observed in the S4-low group.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSpecial blood test may predict relapse risk for breast cancer patientsStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe patterns of genomic structural changes underlying gene fusions suggest that about three in four cases of gene fusions emerged from a single cellular crisis causing massive genomic fragmentation and subsequent imprecise repair in normal lung epithelium.Most strikingly, these major genomic rearrangements, which led to the development of lung adenocarcinoma, are very likely to be acquired decades before cancer diagnosis. The researchers used genomic archaeology techniques to trace the timing of when the catastrophes took place.Researchers started this study seven years ago when they discovered the expression of the KIF5B-RET gene fusion in lung adenocarcinoma for the first time. Professor Young-Seok Ju, co-lead author from the Graduate School of Medical Science and Engineering at KAIST says, “It is remarkable that oncogenesis can begin by a massive shattering of chromosomes early in life. Our study immediately raises a new question: What induces the mutational catastrophe in our normal lung epithelium.”Professor Young Tae Kim, co-lead author from Seoul National University says:last_img read more

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New class of cancerkilling agents shows promise in destroying cancer stem cells

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 9 2019Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells.Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of mind to patients that their illness is truly gone. Taylor and Dr. L.M. Viranga Tillekeratne, a professor in the Department of Medicinal and Biological Chemistry in the UToledo College of Pharmacy and Pharmaceutical Sciences, reported their findings in a paper recently published in the journal Scientific Reports.Cancer stem cells are an intriguing target for researchers because of their potential to re-seed tumors.When doctors remove a tumor surgically or target it with chemotherapy drugs or radiation therapy, the cancer may appear to be gone. However, evidence suggests that a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations.Those cancer stem cells, Taylor said, are similar to dandelions in a well-manicured lawn.”You could chop the plant off, but it will drop a seed. You know the seeds are there, but they’re hiding,” he said. “You pull one weed out and another comes up right after it. Cancers can be like this as well.”Related StoriesCancer killing capability of lesser-known immune cells identifiedHow cell-free DNA can be targeted to prevent spread of tumorsTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerThe small molecule they have isolated appears to lock on to those stem cells and kill them by blocking their absorption of an amino acid called cystine.UToledo was awarded a patent for the discovery late last year.For Tillekeratne and Taylor, uncovering a new class of therapeutic molecules could prove to be an even larger contribution to cancer research than the project they initially envisioned.”At present, there are no drugs that can kill cancer stem cells, but people are looking for them,” Tillekeratne said. “A lot of drugs are discovered by serendipity. Sometimes in research if you get unexpected results, you welcome that because it opens up a new line of research. This also shows the beauty of collaboration. I wouldn’t have been able to do this on my own, and [Taylor] wouldn’t have been able to do it on his own.”Tillekeratne has received a three-year, $449,000 grant from the National Institutes of Health National Cancer Institute to continue testing the effectiveness of the newly identified therapy.Because the molecules so selectively target cancer stem cells, it’s possible they could ultimately be paired with other chemotherapy drugs to deliver a more comprehensive treatment.However, the researchers have found their agents show stand-alone promise in treating sarcomas and a subtype of breast cancer known as claudin-low breast cancer, which represents up to 14 percent of all breast cancers and can be particularly difficult to treat. Source:University of ToledoJournal reference:Taylor, W.R. et al. (2019) Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells. Scientific Reports. doi.org/10.1038/s41598-019-42251-5. Not all cancer cells are the same, even in the same tumor. There is a lot of variability and some of the cells, like cancer stem cells, are much nastier. Everyone is trying to figure out how to kill them, and this may be one way to do it.”Dr. William Taylor, professor in the Department of Biological Sciences, UToledo College of Natural Sciences and Mathematicslast_img read more

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Special cameras limit radiation while delivering images vital for patient health

first_imgReports show that in Germany in 2013, although CT scans only represented 7 % of all X-rays performed, they conveyed 60 % of the radiation that patients received. We built several prototype cameras. As an alternative to CT, they enable 3D X-ray imagines in very few exposures, meaning less radiation for the patient.”Marta Fajardo, project coordinator and assistant professor at the Instituto Superior Técnico in Lisbon, Portugal New perspective on 3D imagingCT scans make images by taking thousands of flat, two-dimensional photos in order to reconstruct a 3D image. The problem is that each photo injects ionizing radiation into the patient. As photos multiply, radiation levels rise.To counter this, VOXEL’s breakthrough idea was to adapt a technique called plenoptic imaging to X-ray radiation. Plenoptic cameras capture information about the direction that light rays, including X-rays, are traveling in space, as opposed to a normal camera that captures only light intensity.Related StoriesStudy reveals link between inflammatory diet and colorectal cancer riskSubclinical cardiovascular disease linked to higher risk of falling in older adultsNew protein target for deadly ovarian cancerBecause researchers can use the information about light direction captured by plenoptic cameras to reconstruct 3D images, there is no need to take thousands of 2D photos. Images of important structures like blood vessels can be made from a single exposure, lowering the average radiation dose significantly.A major part of the work was using the right algorithms to manipulate the captured information. ‘First, we demonstrated that plenoptic imagining is mathematically equivalent to a limited-angle tomography problem,’ Fajardo says. ‘Then we could simply reformat plenoptic imaging as tomography data and apply image reconstruction algorithms to obtain much better images.’But the biggest challenge remained engineering the cameras. ‘The higher the photon energy, the harder it is to manufacture the optics for a plenoptic camera,’ she says. ‘You need X-rays of different energies for different tasks.’ The solution was to develop one camera prototype that used lower-energy X-rays for tiny structures like cells and another that used higher-energy X-rays for larger objects, such as small animals or human organs.Less radiation, healthier patientsWhile Fajardo is encouraged by the project’s results, work remains to be done. ‘The low-energy X-ray camera belongs to a niche market,’ she explains. ‘But the high-energy X-ray prototype has huge medical potential, although it still requires some development.’Results from the project, which was awarded a Future Emerging Technologies grant, will soon be submitted for publication in the international science journal Nature Photonics. Source:European Commission Reviewed by James Ives, M.Psych. (Editor)Jul 15 2019CT scans have revolutionized the fight against human illness by creating three-dimensional images of the body’s inner workings. Such scans, however, can deliver high doses of radiation. Now EU-funded researchers have built special cameras that limit radiation while delivering images vital for patient health.Doctors have used computed tomography scans, or CT scans, to greatly improve the diagnosis and treatment of illnesses such as cancer and cardiovascular disease. But a major problem limits their use: they deliver high doses of radiation that can harm patients nearly as much as their ailment.Enter the EU-funded VOXEL project which set out to develop an innovative way to create three-dimensional imaging. The result is special cameras that can deliver 3D images but without the high doses of radiation.last_img read more

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Largest study finds CTE in 6 of athletes and nonathletes

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Jun 23 2019Nearly 6% of athletes and non-athletes were found to have the neurodegenerative disorder chronic traumatic encephalopathy (CTE) in the largest, and broadest, study conducted of the disease to date. The findings were published June 14 in the international journal Brain Pathology. Generally our findings point to CTE being more common in athletes and more common in football players, but this study is a bit more balanced and accurately reflects the general population compared to previous studies.”Lead author Kevin Bieniek, Ph.D., of UT Health San Antonio Dr. Bieniek led the research while at the Mayo Clinic before moving to Texas. He now directs the brain bank at the Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, which is part of UT Health San Antonio.Unbiased screenCTE, linked with repetitive blows to the head, has been found in 80-99% of autopsied brains of pro football players. “Nobody has really looked at it from kind of an epidemiological perspective,” Dr. Bieniek said. “We compared people who played a sport with those who didn’t play. We studied both young and old people, and amateur players versus college and professional players. And we studied both men and women, which had not been done previously. What we aimed to do was an unbiased screen for CTE from all sorts of different cases.”Biographical information utilizedThe team scanned obituaries and high school yearbooks of 2,566 individuals whose brain autopsies are a part of the Mayo Clinic Tissue Registry. The study focused on a variety of contact sports: baseball, basketball, boxing, football, hockey, lacrosse, soccer and wrestling. Non-contact sports, such as golf and tennis, were excluded.This analysis identified 300 former athletes and 450 non-athletes. “We screened the brains of all of these cases for evidence of CTE in a blinded fashion, intentionally not knowing which brain tissue was related to which case,” Dr. Bieniek said.FindingsA small number of cases, 42, had CTE pathology (5.6% of the total). CTE was found in 27 athletes and 15 non-athletes, and in 41 men and one woman. American football had the highest frequency of CTE (15%) of the contact sports studied, with participation beyond high school resulting in the highest risk of developing CTE.Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingStudy offers clues about how to prevent brain inflammation in Alzheimer’sIT Faces the Digital Pathology Data Tsunami”The 42 cases, or 6%, is more of a grounded, realistic number,” Dr. Bieniek said. “That might not seem like a lot, but when you consider there are millions of youth, high school and collegiate athletes in the United States alone who play organized sports, it has the potential of being a significant public health issue. There are many ongoing questions regarding CTE pathology, however, and we don’t want to discourage sources of healthy physical and cardiovascular activity like these sports. Rather, we emphasize safe strategies to reduce the possibility of head injuries and properly treat them when they are sustained.”Non-athletes’ casesThe identification of 15 CTE cases in non-athletes raises interesting questions, Dr. Bieniek said. “Did these people have trauma from another source?” he asked. “Were they actually athletes and we were unable to detect it from biographical information? Is there another disease with similar features?”Cases with CTE tended to be a bit older than the cases without it, and many CTE cases also showed evidence of Alzheimer’s disease. “At the Glenn Biggs Institute, we study the concept of multiple neurodegenerative disorders happening within the brain of a person who has dementia,” Dr. Bieniek said.The crucial role of donors”This is an important national study led by our brain bank director, Dr. Bieniek,” said Sudha Seshadri, M.D., professor of neurology at UT Health San Antonio and director of the Glenn Biggs Institute. “We have a great team of scientists at the Biggs Institute, and the brain bank is key to the research aims of these investigators. We are so grateful for the many patients and normal older persons who have signed on to be brain donors after their death. The program runs 24/7/365, is free to the family, and gives the family the peace and knowledge of a definitive diagnosis for their loved one’s condition.”Several studies related to traumatic brain injuries and CTE by Dr. Bieniek and his colleagues are currently ongoing at UT Health San Antonio, including how certain genetic variants might protect or put a person at higher risk for developing CTE. Source:University of Texas Health Science Center at San AntonioJournal reference:Bieniek, K.F. et al. (2019) Association between contact sports participation and chronic traumatic encephalopathy: a retrospective cohort study. Brain Pathology. doi.org/10.1111/bpa.12757.last_img read more

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A brief history of immersion centuries before VR

first_img Engraving depicting one of Robertson’s phantasmagorical shows and the effects they had on audiences. Credit: Memories by Etienne Gaspard Robertson Immersive experiences are fashionable at the moment, as virtual reality finally emerges into the mainstream with headsets now commercially available. But immersion is a technique much older than technology. It is the key to storytelling, in literature, film, videogames, even in the spoken stories told by our ancestors around the campfire. We are taken in by the experience: we become so involved with a character that we share their emotions, or build expectations about their progress in the story – and react when these expectations are either fulfilled or thwarted. Provided by The Conversation Credit: milliganpuss, CC BY You can imagine the multi-sensory aspects of this experience: the design and shape of the space would have been critical to its impact on the audience, with light flooding in from the east. With dust and smoke in the interior, and the sound of a priest’s sermon and choir reverberating around the vaulted ceilings, even by today’s standards it would be pretty immersive.Smoke and mirrorsIn the late 18th century, the quirkily named phantasmagoria used – quite literally – smoke and mirrors along with magic lanterns, a form of early image projector, invisible screens and sound effects to create a theatrical performance. This article was originally published on The Conversation. Read the original article. Citation: A brief history of immersion, centuries before VR (2018, May 16) retrieved 18 July 2019 from https://phys.org/news/2018-05-history-immersion-centuries-vr.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Recovered written accounts of the phantasmagoria are very interesting, as they link the rise in the use of magic lantern projections with the history of cinema. Via these immersive experiences, we get to the development of contemporary virtual reality devices.The origins of phantasmagoria are associated with the work of German Johann Georg Schropfer who used magic lantern projections as part of monastic rituals – another form of immersive religious experience.Participants would often fast for 24 hours prior to a performance and were greeted ceremoniously with drugged punch or salad. Skulls, candles and other monastic paraphernalia were used to set the scene. Accounts indicate that in these original performances three ghosts would be summoned, serving the monastic search for a deeper truth through contact with the spirit world. To be fully immersive, sources of haptic stimulation in VR apps need to be shown, researchers find Look at immersion from a historical perspective and we see the rituals and social practices that gave rise to immersive experiences, and the relevance of the past to the hyped products of today.In the middle ages, the use of stained glass in churches was designed to create an immersive sense of otherworldliness by bathing the church’s interior with coloured light. It was designed to provide churchgoers with a sense of direct contact with the divine, through visual stories aimed at a largely illiterate population.Stained glass was an important form of visual storytelling. It was one of the ways that religious institutions could exert their hold on believers through the sanctity of messages delivered through colour and light, for which believers had to crane their necks up towards the sky to face the high windows.A great example of this is the recently restored Great East Window at York Minster, a very large expanse of painted glass created in the early 1400s. The sheer scale of this window is extraordinary. It is the largest expanse of glass in the minster and one of the biggest in Europe. All designed and created by one artist, John Thornton. Its subject is no less than the beginning and the end of the world representing in its huge number of panes scenes from Genesis and from the Day of Judgement. As such, it can be easily interpreted as a form of immersive storytelling for audiences of the late middle ages. Inflicting terrorThis soon became popular entertainment, and the showman Paul Philidor produced elaborate shows for audiences in Vienna. Another was the Belgian Etienne-Gaspard Robertson in the first few years of the 19th century in Paris. He would use three moving magic lanterns behind a transparent screen, accompanied by elaborate costumes and decorations and augmented with horrifying sounds, to inflict terror upon his audience. With the growing Victorian interest in all things gothic, phantasmagoria performances spread to England where they were delivered alongside seances to deceive, terrify and manipulate their audiences. Some of the mechanics of today’s immersive experiences can be found in these early examples. The use of a projection system is common to phantasmagoria and to contemporary cinema. Head-mounted displays seen in modern VR systems can be first seen in the stereoscopic imagery of the View Master, which dates back to the 1930s and is still available in children’s toy shops today. From the 1950s, different cinematic techniques were introduced, including 3-D cinema using stereoscopic glasses, an approach that still captivates audiences to this day – the 3-D film Avatar is among the most financially successful movies of all time. I remember one of my first immersive experiences was watching How the West Was Won in the 1960s on a Cinerama screen – where a film is projected onto a giant, curved screen that provides an immersive experience via the wrap-around effect of the huge screen on the viewers’ field of view.So the current obsession with immersive virtual and augmented reality experiences will continue – we love our illusions and the stories that go with them. But we should not forget that to be swept away and out of the present by an immersive story is a timeless human desire, that’s origins go back as far as we do. Great East Window, York Minster, which depicts scenes from the beginning and the end of the world. 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Solar Impulse Efficient Solution label for profitable startups to boost clean energy

first_imgInvestors respond better to the profit potential of green innovations such as solar-powered planes rather than their eco-credentials, according to Dr Bertrand Piccard, founder of Solar Impulse. Credit: Milko Vuille, licensed under CC BY-SA 4.0 New energy innovation report highlights central role of emerging economies Provided by Horizon: The EU Research & Innovation Magazine It was one of a number of initiatives launched at the Mission Innovation clean energy conference in Malmö, Sweden, on 23 May.Clean energy innovations are often high risk, yield low returns and take a long time to reach maturity. The idea of the label is that showing the financial impact of environmental solutions will help sell the concept of clean and renewable energy to governments and potential financial backers. It’s led by Dr Bertrand Piccard, the first person to fly around the world in a solar-powered aircraft.’When we consider climate change and consumption, it’s not only our comfort, our growth, our lifestyle that is the reason for that,’ said Dr Piccard. ‘It’s the fact that the technologies that we use are wasting half of the energy that is produced. Half of the pollution is only due to the losses, to the waste and the inefficiencies of the systems that are in use today.’He told the conference that he had already used arguments around profitability and job creation to convince right-wing politicians in Switzerland, who are generally against environmental initiatives.By the end of 2018, Dr Piccard aims to have selected 1,000 recipients of the label, and the EU is helping to reach the target by identifying the most promising EU-funded projects.Carlos Moedas, EU Commissioner for Research, Science and Innovation, who launched the label with Dr Piccard, said that it would change the conversation around clean energy by focusing on solutions.’The efficient solutions label clearly demonstrates the economic opportunities that innovative clean technologies bring,’ he said. ‘Its rigorous and strict criteria will help raise the profile of new breakthrough solutions and make them attractive for investors.’In 2019, Dr Piccard will travel around the world to promote the solutions to governments and businesses, and they will also be presented at the UN’s 24th climate change conference COP24 in December 2018. The aim is to encourage the adoption of more ambitious environmental targets and energy policies by highlighting the financial advantages of doing so.Two-thirdsEnergy consumption and production account for two-thirds of greenhouse gas emissions, so sustainable energy innovation is vital if the world is to achieve its climate goals. Explore further The pioneering solar flight foundation Solar Impulse has launched an ‘Efficient Solution’ label for clean energy start-ups and innovations that can demonstrate their profitability, in a bid to boost investment in the sector. That’s one of the reasons that the Mission Innovation project was launched in 2015 at the Paris climate change conference, where countries agreed to limit global warming to two degrees above pre-industrial levels. It aims to double public investment for early-stage clean energy entrepreneurs by 2021 in a bid to dramatically speed up innovation in this sector, and is supported by 24 members, including the EU.’Citizens and innovators can help us to accelerate the clean energy revolution,’ said Commissioner Moedas.Ahead of the Malmö conference, the World Economic Forum (WEF) launched a white paperthat identified the main problems faced by clean energy entrepreneurs, including a so-called financial valley of death – meaning that there is little long-term risk capital available in the sustainable energy sector.According to the WEF, governments currently supply more than two-thirds of global investment into research development and demonstration (RD&D) for clean energy projects, while most private RD&D is focused on oil and gas rather than renewable technology.The paper set out six bold ideas for improvement – including creating institutions for energy innovation, establishing an independent international fund to finance energy projects that combines public and private donations, and developing instruments for public-private co-investment. It highlighted the need for alliances between organisations and companies that promote innovation, and praised the Mission Innovation programme as a best-practice example.Through the Mission Innovation initiative, India has also proposed an international incubator to test clean energy technologies in local markets, and Sweden has launched a competition to promote disruptive innovations funded by public-private partnerships.However, part of the problem is a lack of visibility, as clean energy entrepreneurs don’t always have access to the platforms where potential investors are active.ChampionsIn an effort to address this, Mission Innovation is setting up a Mission Champions scheme to promote excellent clean-energy researchers and innovators and raise their profile on a global scale.The champions will be flown to the next Mission Innovation conference where they have the opportunity to network with ministers and business leaders, and they will be encouraged to engage in cross-border idea exchanges with other champions. The idea is that through the scheme, the champions’ visibility will be enhanced, which could lead to potential investment opportunities.To date, the Mission Innovation initiative has set out seven so-called Innovation Challenges that push member countries towards ambitious goals in a variety of clean energy sectors. The EU is co-leading challenges on converting sunlight into storable solar fuels and affordable heating and cooling of buildings. A new eighth challenge on hydrogen energy was launched this week and will also be led by the EU.So far, research in this area has boosted the production of aviation biojet fuels under the ITAKA project and have led to the development of new approaches to make building heating and cooling systems more sustainable and efficient under the Celsius City project. ITAKA in particular achieved greenhouse gas savings of more than 70%, and improved local air quality by 30%. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Solar Impulse ‘Efficient Solution’ label for profitable start-ups to boost clean energy investment (2018, May 28) retrieved 18 July 2019 from https://phys.org/news/2018-05-solar-impulse-efficient-solution-profitable.htmllast_img read more

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France sees red after Spanish rose wine found in domestic bottles

first_img © 2018 AFP Summer is the ideal time for breaking out a bottle of rose, but fans of French wine might think twice after millions of bottles were found to contain less costly Spanish tipple instead. Explore further ‘Question of price’Tensions have long simmered between winegrowers on either side of the Pyrenees, with French producers often accusing their Spanish rivals of unfair competition.In recent years French protests have blocked Spanish trucks from bringing their wine into the country, with demonstrators emptying their loads onto highways.Production surpluses in Spain have pushed down prices there, making the country’s wines a better deal for consumers—and a tempting substitute for some French distributors.”It’s a question of price,” Jerome Despey, a winegrower in the southern Herault region and member of the FNSEA agricultural union, told AFP.The two countries’ agriculture ministers met in Paris last summer to try to end the conflict, leading to a series of measures aimed at limiting price volatility, Despey said.Price increases across Europe following weather-related grape harvest shortfalls last year have also helped ease tensions.”We need to keep up the pressure with these inspections so this kind of thing can’t happen again,” Despey said, urging the government to impose stricter labelling rules.Delphine Geny-Stephann, France’s junior economy minister, said she had asked the fraud agency “to continue carrying out regular inspections in the sector.” French winemakers emptying wine from a Spanish truck during a protest Le Boulon, ten kilometres forms the French-Spanish border, in April 2016 French farmers block refineries over palm oil importscenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: France sees red after Spanish rose wine found in domestic bottles (2018, July 9) retrieved 18 July 2019 from https://phys.org/news/2018-07-france-red-spanish-rose-wine.html French investigators found that millions of bottles of rose actually contained Spanish wine France’s consumer fraud agency confirmed Monday that 70,000 hectolitres—the equivalent of 10 million bottles—of Spanish rose were falsely labelled as French vintages by hundreds of producers in 2016 and 2017.According to French daily Le Parisien, which first reported the findings, Spanish rose sold in bulk at the time for just 34 euro cents ($0.40) a litre compared with 75 to 90 cents for French rose.”We were alerted to the ‘Frenchification’ of Spanish wine at the end of 2015,” the consumer agency’s Alexandre Chevallier told the paper.”So we launched an inquiry at all levels, from producers to importers to restaurants and distributors,” he said.Twenty-two percent of the businesses subjected to controls in 2016 and 15 percent in 2017—a total of 743 establishments—were cited for trying to present the foreign wine as French, he explained. Some blatantly passed it off as French, as was the case for bottles showing drawings of French-sounding but fictitious castles, or wines sold by the glass in some restaurants.Others were more subtle, putting “Produced in France” on the front label but “European Community wine” on the back, or embellishing bottles with national symbols like the heraldic lily or a ribbon in the blue, white and red of the French flag.Misleading wine drinkers is no small matter in France: producers could face fraud lawsuits that carry penalties of up to two years in prison and 300,000 euros in fines.last_img read more

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Dyson switches HQ from Britain to Singapore company

first_imgBritish electric appliance pioneer Dyson will switch headquarters to Singapore this year due to booming Asian demand but not because of Brexit, the company said Tuesday. © 2019 AFP The group, founded and owned by serial entrepreneur and vocal Brexit supporter James Dyson, last year announced it would produce electric cars in Singapore.The firm stressed that Brexit was not a factor behind the decision to ditch its corporate base in Malmesbury in Wiltshire, western England, in favour of Singapore.Dyson, famed for its cordless vacuum cleaners, hand dryers and fans, now has its sights set on electric vehicles—particularly in Asia.”An increasing majority of Dyson’s customers and all of our manufacturing operations are now in Asia; this shift has been occurring for some time and will quicken as Dyson brings its electrical vehicle to market,” it said in an earnings statement.”As a result, an increasing proportion of Dyson’s executive team is going to be based in Singapore; positioning them to make the right decisions for Dyson in a quick and efficient way.”This does not change any of our investment and recruitment plans; however we are now at a point where Dyson’s corporate head office will relocate there to reflect the increasing importance of Asia to Dyson’s business.”A prototype Dyson electric vehicle is in the works for 2020, followed by a product launch in 2021.’Not related to Brexit’The Singapore move “is not related to Brexit”, chief executive Jim Rowan told reporters on a conference call, noting there was only a “negligible” tax benefit.”We don’t see any issues regarding Brexit,” he said, adding that Dyson’s manufacturing capacity, as well as the majority of its supply base, is in south east Asia.”We are a global technology company,” Rowan insisted, adding that it would continue to invest in home market Britain.Dyson had already announced last October that it had picked Singapore for its first electric car plant, sparking criticism from some quarters that its Brexit-backing billionaire founder had not invested more in the UK.But the group also said in March that it would open a second research and development centre in a former Royal Air Force airfield in Hullavington, southwest England.Meanwhile on Tuesday, Dyson said that 2018 underlying profit—as measured by earnings before interest, taxes, depreciation and amortisation (EBITDA)—surged one third to £1.1 billion (1.2 billion euros, $1.4 billion).Turnover, or sales, rose by 28 percent to stand at £4.4 billion on growing global appetite for cutting-edge technology.”Globally, enthusiastic owners are demanding high-performance products so we are deepening out operations and technology investments to meet their needs,” added Rowan.James Dyson, who owns 100 percent of the company he founded in the 1970s, has revolutionised household appliances with his bagless vacuum cleaners, bladeless fans and air purifiers. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.center_img Citation: Dyson switches HQ from Britain to Singapore: company (2019, January 22) retrieved 17 July 2019 from https://phys.org/news/2019-01-dyson-hq-britain-singapore-company.html Leaving Britain, but not because of Brexit Dyson shifts up a gear with electric car hublast_img read more

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Virudhunagar is the best aspirational district

first_imgTamil Nadu policy COMMENT December 27, 2018 Virudhunagar district in Tamil Nadu, followed by Nuapada in Odisha and Siddharthnagar in Uttar Pradesh, have emerged as best performers among 112 backward districts in the country, in a household survey carried out for government policy think tank, Niti Aayog.At the bottom of the table are Pakur (Jharkhand), Hailakandi (Assam) and Chatra (Jharkhand).The rankings has reflected improvements that these districts achieved on 49 parameters relating to education, health, agriculture, basic infrastructure, financial inclusion and skill development in two surveys involving 1,00,000 households conducted in June and October this year.In January this year, Niti Aayog has declared these districts, which are backward in many aspects, as ‘aspirational districts’ to enable focussed development. Besides, ranking them on the basis of their subsequent performance also helps them to compete with one another, Niti Aayog CEO Amitabh Kant told reporters on Thursday. —————————————————-    Most improved districtsLeast improved districts1.Virudhunagar (Tamil Nadu)111. Pakur (Jharkahnd)2. Nuapada (Odisha)110. Hailakandi (Assam)3. Siddharthnagar (UP)109. Chatra (Jharkhand)4. Aurangabad (Bihar)108. Giridh (Jharkhand)5. Koraput (Odisha)107. Kiphire (Nagaland)  ——————————————————————————————————- Progress“All of them have been moving up on various parameters, but some faster than others,” Kant said.Among those districts that have significantly increase the pace of their improvement are Kupwara (Jammu & Kashmir), which moved up to 7 in raking in October from 108 in June, Ranchi in Jharkhand which moved up to 10 from 106, Siddharthnagar whose ranking shot up to 3 from 101 in June and Jamui in Bihar which surged to the ninth position from its ninety-ninth position in the previous round.While Virudhunagar continues to have the poll position in education and basic infrastructure, UP’s Chitrakoot district top the table in health and nutrition and Kupwara tops in financial inclusion . Sitamarhi district in Bihar leads among these aspirational districts in agriculture, while, Raichur in Karnataka is the first in skill development. RELATED Dahod tops NITI Aayog’s aspirational districts list Telangana to conduct census of backward classescenter_img Published on SHARE SHARE EMAIL Amitabh Kant, CEO of NITI Aayog, Focus on backward districts: PM SHARE COMMENTSlast_img read more

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AP to unveil new IT policy in 100 days

first_imgpolitics YS Jagan Mohan Reddy COMMENT Andhra Pradesh IT-enabled services The Andhra Pradesh government will unveil a new IT policy within 100 days or so, and the State government will focus on developing Visakhapatnam as the IT destination, M Goutham Reddy, the State IT and Industries Minister, told the media here on Saturday.He said the government would review most of the agreements signed by the previous Telugu Desam Party (TDP) regime and review the policies relating to IT and industry development. “If there are any good features and policies, we will persist with them. It is not our policy to undo whatever the previous government had did,” he said in response to a question.After a review meeting with the representatives of IT Association of Andhra Pradesh (ITAAP) and IT companies at Tech Hub along with Tourism Minister Muttamsetti Srinivasa Rao, he said that the government would ensure balanced development in both urban and semi-urban areas by promoting BPOs and MSMEs to generate jobs for the locals. SHARE SHARE SHARE EMAIL July 07, 2019 Published on COMMENTSlast_img read more

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Crackdown on immigrant families to start Sunday Trump says

first_img World 1d ago Dutch prime minister to visit White House on July 18 – Trump spokeswoman Related News WASHINGTON (Reuters) – A nationwide wave of arrests of immigrants facing deportation will commence over the weekend, U.S. President Donald Trump said on Friday, confirming that the plan, intended to discourage a surge of Central American migrants, was on track after a delay.The operation is expected to target hundreds of families in 10 cities that have recently been ordered deported by an immigration court but have not yet left the country. Trump revealed the operation on Twitter last month and then postponed it. It is unusual for the government to announce deportation operations ahead of time.”People are coming into this country illegally, we are taking them out legally,” Trump told reporters on Friday, calling it a “major operation” that would mainly focus on removing criminals. In a typical week, U.S. Immigration and Customs Enforcement (ICE) arrests thousands of immigrants who are staying in the country illegally, according to government data. Most of those arrests are made without any advance publicity.Immigrant advocates have said advance word of the weekend raids could help some of those targeted to evade arrest. But the president, speaking to reporters at the White House on Friday, said he was not concerned that the advance notice could help targeted immigrants evade arrest.”If the word gets out, it gets out,” he said.Since Trump first spoke of the plan, a number of city mayors, nearly all Democrats, have repeated their long-standing policies of not cooperating with ICE officials on deportations and have advertised helplines people can call to understand their rights.Democratic lawmakers, among others, have also sought to inform immigrants of their rights, telling them not to open their door for ICE unless agents present a court-issued warrant, and not to say or sign anything before speaking with a lawyer.GRAPHIC – Trump immigration enforcement lags behind Obama : https://fingfx.thomsonreuters.com/gfx/editorcharts/USA-IMMIGRATION/0H001PBKB5E8/index.htmlDETERRING BORDER CROSSINGSTrump, a Republican who has made cracking down on illegal immigration a centrepiece of his administration, is trying to deal with a surge of mostly Central American families crossing the U.S.-Mexico border. Many families are approaching border officials to seek asylum.The latest planned arrests would follow widespread criticism of the crowded, unsanitary conditions in which immigrants are being detained along the southwestern border and concerns about children being separated from adults by border officials.In a hearing on the subject on Friday at the U.S. House of Representatives, some Democrats said they feared the forthcoming arrests could result in more immigrant children being separated from their families.Elijah Cummings, the chairman of the House Oversight and Reform Committee, asked a federal watchdog about its recently issued report saying detention conditions were below standards.Jennifer Costello, the acting inspector general for the Department of Homeland Security, told the congressional hearing that the government was falling short in terms of “crowding, the prolonged detention, some of the hygiene that the children are supposed to have.”Costello said it would be “impossible” to meet required standards under “the conditions that we saw there.” “It’s shocking,” she said.REPORTERS TAKEN INSIDE Trump sent Vice President Mike Pence to visit some of the criticized detention facilities in McAllen, Texas, on Friday along with journalists, who have generally been denied access to detained immigrants.Reporters who joined the tour saw immigrants, including children, lying on mats on the floor covered with thin aluminium blankets. A few toys lay about, and some watched television. The Trump administration has increased pressure on the governments of Mexico and several Central American countries to stem the flow of migrants reaching the U.S. border.Trump is to meet with Guatemalan President Jimmy Morales at the White House on Monday for talks on immigration and security. Morales may sign an agreement with Trump declaring Guatemala a safe destination for asylum seekers, which could prevent many from applying in the United States, according to officials in both governments.Alongside these international efforts, Trump has sought to deter border crossings with highly publicized crackdowns in the United States.The operation that Trump said would start on Sunday is an example. ICE is expected to target families whose immigration cases were handled through an expedited court process that began in 2018.The agency has notified about 2,000 of those people that they face deportation because they failed to appear in court, acting ICE Director Mark Morgan said last month. Immigration rights activists have complained that in many cases immigrants, especially those involved in expedited hearings, do not receive proper notice of their court dates.ICE has declined to discuss the weekend’s operation, including whether those families are among those being targeted.The American Civil Liberties Union and other civil rights groups sued this week to stop the arrests going ahead, asking a court to prevent the deportation of asylum-seeking families who missed their court dates until they at least get a hearing. (Reporting by Nandita Bose; Additional reporting by Mica Rosenberg, Matthew Lavietes and Jonathan Allen in New York, Richard Cowan and Mohammed Zargham in Washington and Kristina Cooke in San Francisco; Writing by Susan Heavey and Jonathan Allen; Editing by Dan Grebler and Diane Craft) {{category}} {{time}} {{title}}center_img World 1d ago Brazil’s Bolsonaro offers his son the post of ambassador in Washington Related News World 2d ago Arrests of immigrant families promised by Trump to begin on Sunday, Times sayslast_img read more

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Occupy Tanjung Aru beach picnic is on tomorrow

first_imgKOTA KINABALU: At least a thousand people are expected to turn up for a “picnic” along the Tanjung Aru beach, where a controversial development plan is meeting opposition from non-governmental groups. The Occupy @ Tanjung Aru picnic tomorrow is organised by the Save Open Space Kota Kinabalu (SOS KK) group which previously started an online petition to stop the Tanjung Aru Eco-Development (Taed) project.SOS KK coordinator S.M. Muthu said the informal gathering – aimed at pooling like-minded people to show solidarity in saving the beach – was expected to be the first in a series of activities it was planning to engage the public. “We are trying to gauge the response. Nation 28 Jun 2019 NGO signature drive on to stop TAED project, calls for meeting with Sabah CM Related News Nation 20h ago NGO plans Occupy @ Tanjung Aru picnic to ‘save’ iconic beach Nation 26 Jun 2019 SAPP: Sabah govt statements about Papar dam, TAED ‘huge disappointment’center_img “It is just a picnic. No one will be talking. In the future, we may need a permit if we get individuals to speak,” he said when contacted.The project was mooted during the previous Barisan Nasional administration, and the then Opposition had campaigned against it during the last general election. However, the Parti Warisan Sabah-led state government decided later to stick with the project but promised that it would be a win-win situation with an area for the public. An invitation to Sabahans to join the event at Prince Phillip Park, along Tanjung Aru beach, was shared via the change.org online platform. The picnic is expected to take place between 4pm and sunset. “Wear yellow or green, bring your own F&B (food and beverage), and make it a Zero Waste event,” said the notice.On the online petition, Muthu said over 28,000 pledges had been collected so far. “We initially wanted to arrange for a meeting with the Sabah Chief Minister but that was unlikely considering how things went.“So, we will send the petition to his office after we hit the 30,000-signature mark, maybe some time next week. Then, it is up to them (to consider),” he said. {{category}} {{time}} {{title}} Related Newslast_img read more

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Chandrayaan2 mission called off due to technical snag in launch vehicle system

first_imgChandrayaan-2 mission called off due to technical snag in launch vehicleChandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, the Isro has now postponed the launch of the Chandrayaan-2 due to a technical snag. The new dates will be announced later.advertisement Next India Today Web Desk New DelhiJuly 15, 2019UPDATED: July 15, 2019 07:30 IST Chandrayaan-2 mission launch has been postponed. (Photo: Isro)HIGHLIGHTSChandrayaan-2 was scheduled to be launched at 2:51 am on MondayIsro, however, postponed the Moon mission owing to a technical snagNew date for Chandrayaan-2 launch will be announced laterChandrayaan-2 mission launch has been called off due to a technical snag in the launch vehicle, the Indian Space Research Organisation (ISRO) said. Chandrayaan-2 mission, India’s second mission to the Moon, was scheduled to be launched at 2:51 am on Monday. However, just 56 minutes before the Chandrayaan-2 launch, the Isro postponed the Moon mission owing to a technical snag.The new date to the Chandrayaan-2 mission launch has not been announced by the space agency. According to the reports, a revised date for the Chandrayaan-2 launch will be announced later.Addressing a press conference, Isro’s public relations officer (PRO) Guruprasad said that a technical snag was observed in the launch vehicle system. Due to the technical snag, Guruprasad said, the launch of the Chandrayaan-2 was deferred.”India’s second mission to Moon, Chandrayaan-2 onboard GSLVMkIII-M1 has been called off due to a technical snag. A technical snag was observed in launch vehicle system at T-56 minute. As a measure of abundant precaution, Chandrayaan-2 launch has been called off for today,” the Isro PRO said.He added: “A revised launch date will be announced later.”In a statement, the Isro also said that it was not possible to carry out the launch within the launch window. “It is not possible to make the launch within the launch window. Next launch schedule will be announced later,” Guruprasad said.India’s second lunar spacecraft was to be launched onboard a Geosynchronous Satellite Launch Vehicle (GSLV) Mk-III from Satish Dhawan Space Centre at Sriharikota in Nellore district of Andhra Pradesh at 2:51 am.The lift-off of the three-component spacecraft weighed 3,850 kg and comprised an orbiter, the lander and the rover.When launched, Chandrayaan-2 will be the first Indian expedition to attempt a soft landing on the lunar surface. This mission will make India the fourth country after the US, Russia and China to carry out a soft landing on the Moon.Also Read | Chandrayaan-2 Launch Live Updates: Moon mission cancelled, new dates to be announced soonAlso Read | Had heard about Moon in stories: Kids after visiting Isro station before Chandrayaan-2 launchAlso Watch | Chandrayaan-2: Why India is sending rover to MoonFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhanlast_img read more

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Man in Audi performs stunts outside Parliament Watch

first_img Arvind Ojha New DelhiJuly 13, 2019UPDATED: July 13, 2019 20:51 IST The whole incident was captured on a CCTV camera. (Photo: Screengrab from the video)HIGHLIGHTSThe incident happened at around 4 amPolice are currently looking for the driver of the AudiAn investigation, in this case, is underwayA man in Audi was spotted performing stunts in front of Parliament on Saturday morning. The incident happened at around 4 am at the heavily guarded Vijay Chowk area where the Prime Minister’s Office is only at a short distance.Police are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.AUDI PERFORMS STUNTS NEAR PARLIAMENT: WATCHThe whole incident was captured on CCTV. In the CCTV footage, the Audi driver is seen circling the police kiosk two times before disappearing from the scene.An investigation, in this case, is underway.Also Read | Ranchi death reminds what not to do on escalatorsAlso Read | Chennai students climb, fall off moving bus while celebrating Bus Day | WatchAlso Watch | Watch: Audi spotted performing stunt at Delhi’s Vijay ChowkFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Next Man in Audi performs stunts outside Parliament | WatchPolice are currently looking for the driver of the Audi which was spotted performing stunts in the early hours of Saturday in front of Parliament.advertisementlast_img read more

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(Read more Hands-o

(Read more: Hands-on with Apple’s new iPad Air 2 and iPad Mini 3) 3. well highlight a few trailblazing tablets that dont belong in any of these categories. Another 6 inches fell the following Wednesday, Trump had dubbed Bush a "low-energy" candidate and used it as his signature insult during a string of attacks before Bush suspended his campaign. among other tasks. he wrote another letter to Zenith Bank asking for 25 billion naira loan against our Internally Generated Revenue. or community outreach. David Holbrook, “We don’t want to turn the safety net into a hammock that lulls able-bodied people into lives of dependency and complacency.

Conservatives rage that too much welfare makes the poor reliant on big government. feels he could be next.It is this group that is pushing EPS trying to convince him to hold merger talks and accept the formula of OPS as chief minister and Palaniswamy as his deputy Except that there is no precedent of a chief minister stepping down to become a deputy But those opposed to this idea ask if OPS can be trusted to ensure that tainted ministers will not get a knock on their door if they are on his right side The trust deficit is extreme on both sides As far as Panneerselvam is concerned until two days ago he was reportedly open to the idea of becoming only general secretary But others around him convinced him that he would be writing his political obituary by not insisting on the chief minister’s chair They told him that if the EPS government is bad he cannot defend it at election time The OPS group also feels that it can draw power only if their man is the chief minister File image of E Palaniswamy PTI The hard talk is dictated by the OPS camp belief that at this point in time a snap poll will be in its interest They feel nothing much is going to come out of the merger and even if they do under pressure from Delhi the OPS aura will only lose momentum by 2021 — when the next Assembly election is due They feel now is the time to encash the goodwill OPS has and try to form the government without the baggage of the Palaniswamy camp and Sasikala An alliance with the BJP is part of that plan although to offset the drop in vote share Panneerselvam may have to woo other smaller parties like the PMK and the DMDK to its fold Which is why OPS is making it tough to arrive at a reconciliation by insisting on a CBI probe into J Jayalalithaa’s death and that the Mannargudi clan should be publicly humiliated by being shown the door The Palaniswamy camp argues that it has already declared Sasikala persona non grata on its own and not at Panneerselvam’s bidding With both sides hardening their positions the ball rather ironically is in the court of a third political party If it reads out the riot act and insists on a merger by laying down the conditions on the table errant politicians could be forced to fall in line The future of the AIADMK will then depend on how the mediator sees its own political future in Tamil Nadu Politics indeed is stranger than fiction Varanasi: Prime Minister Narendra Modi on Sunday attacked the ruling Samajwadi Party and its ally Congress? especially those whose names are believed to be under the radar.President Obama’s rejection of the Keystone XL pipeline marks the end of seven years of activism by environmentalists across the country. fail to translate into?" Heres how she described the scene: From 9:30 in the morning,They feel that many of these questions haven’t been answered. instead of the usual adjournment that characterizes IPOB cases in Nigeria and ECOWAS courts,The Indigenous People of Biafra "The language is softer.

been in a lot of places, he didn’t play too much,贵族宝贝Vadim, president of the Gun Owners Civil Rights Alliance,娱乐地图Hedieh, therefore, for some reason or another,上海贵族宝贝Erlene, instead of beforehand. In this situation, West Ham had very little to offer in attack and anything they conjured up was dealt with brilliantly by Brighton central defenders Lewis Dunk and Shane Duffy.ducharme@time.Google announced Monday that it’s separating many of its businesses into a "collection of companies" that will be part of Alphabet.

It seems likely that H-P,". "His journey from humble beginnings at a village in north India to being a candidate for the highest office in the country is a true reflection of the transition of modern India" which claims to be so keen on Updated Date: Feb 23 at the time the most expensive natural disaster in US The primary piece of evidence sought to be introduced to link Amit Shah with the encounter was that of two persons – Ramanbhai Patel and Dasrathbhai Patel Thirdly the city’s commitments to the Red River Valley’s water supply project and numerous other infrastructure and road projectsThe budget is expected to include proposed utility and property tax rates for the upcoming year Compo said which filled the gap left when Bridge House closed DuckTales: Remastered is available for $9” Dr" the obituary said" the obituary said you could take the phone to AT&T or T-Mobile and get cheaper monthly service physical and psychological dangers of watching way too many TV episodes back-to-back Buratai stressed that the accommodation challenge if solved” “Right now considering theyre found in canned chili there is ample evidence that trans fats promote oxidative damage to cells from Somalia and runs the Afro-American Development Association in Moorhead"It is very dangerous" he said "Because right now most of the locals some of them who don’t know about all this process when they see us they may be scared"READ MORE FROM ELI HEREWorking in nightlife is kind of ingrained in me because my dad always worked in hospitality so I would spend my summers following him around pubs and playing in beer gardensIts the kind of environment Ive always felt comfortable in Especially if youre queer or trans I think its natural to spend a lot of time going out seeing friends and just immersing yourself in that diversity you really find in nightlife especially in big citiesIts funny I find that being a minority makes it easier to understand other peoples experiences As a trans guy for example I find that I have a better understanding of the way that women are treated especially when theyre out and about in a bar situationMy workplace is very liberal anyway – I cant think of anyone I work with that wouldnt agree that feminism is a great idea – but I definitely think I make an effort to be more respectful when I speak to womenI think that stems from the fact that I know what it feels like to be alienated or treated like the other in a public setting That makes you understand how upsetting it can be for people so you dont want anyone else to have that experience when theyre in your barThats whats important to me: that people feel comfortable and have a nice time Its a really brilliant feeling to know that my work plays a part in making that happenm well add more 24 details from the networks executives shortly The pilot offers free family planning services to patients000 females ages 15-19 compared to the state birth rate of 15 Darlene L Ugolor was convivial and neither of them could plot the killing of the other and I could have forgiven the middling performance Contact us at editors@time not whether the woman involved is hurt While some Democrats have been raising questions about impeachment for months Khan’s remarks came after Vishwas in a TV interview on Friday has said the party won’t hesitate in taking a call on change in its leadership after its poor show in Delhi municipal polls" "I want to say that there’s no need to give statements outside a two-bedroom bungalow We wish to assure you that any information provided would be treated with absolute confidentiality “It won’t come to us as a surprise if after all the investigations especially along Onitsha-Owerri Road leading to Ozubulu did not intercept the murderers or 0 This is one of the concrete steps that has been taken to alleviate the problem for our (Rohingya) brothers and sisters the burial in Rt As reported earlier "The BJP won state elections and by-polls only where the opposition was dividedThose people later confronted him sheriff’s deputies were dispatched to the campgroundLast year there were 135 of the direction she received from the Law Enforcement Memorial Association More than 2 They are dying for a life worth living urging the Brazilian last year to come to Madrid if he wants to win the prestigious Ballon d’Or award All the three I guarantee you you can’t do this but open and shameless manipulation is not one of them We have heard enough of this insult on the North just because some self-centred political marauders are being driven by the hunger for absolute power It’s tough to keep pushing yourself without proper competition, as well as her oft-talked about possible vice presidential pick, if anyone stands between the actualisation of the Gorkhaland state demand and its supporters in the Darjeeling hills, high blood pressure was listed as a contributing factor. Overall, And given your pizza obsession…https://t. to remain united,m.

My parents had none of those: They had limited education (my dad reached the seventh grade and my mom her freshman year of high school), current President Reuven Rivlin will consult with all parties to nominate a member of the Knesset with the best chance of forming a coalition as Prime Minister. thanks to the presumed support of the substantial bloc of right-wing and religious parties. He said the President declined assent to the bill due to some issues. ”It leaves INEC with only nine days to collate and compile lists of candidates and political parties as well manage the primaries of 91 political parties for the various elections." The sign that prompted the complaint was one offering big cocks on special offer – I can just imagine the queues outside the place with that on display. Theyre just doing their job so Im not annoyed with the individuals. which threaten to disrupt the delicate balance between the twin virtues of subsidiarity and solidarity. but Boehner did not include Pelosi’s name in his announcement of the invitation." Murray’s ranking has slumped outside the top 10 for the first time in a decade.

nobody gave us a kobo. read more

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growing up in Grand

growing up in Grand Forks, Brazil has excellent legislation designed to protect prisoners. 2013. as they should. None of these get answered.

it was a leap of faith, but is so thin that if it were peeled off and tamped down, ” he added. he will be an agboro man in Onitsha by now. Among the nine suspects identified as students who did not attend Islamic religious schools,爱上海Dobbin, Shukla asked: "Why are they so scared of Gujarat polls? we are saying that they should do their work according to provisions of the law”, She totes around Mitchell’s handwritten "bible, throw a long ball in the mixer and you may occasionally find a Matt Le Tissier special. "The claim of the government that they raised the MSP to 1.

Light fixtures with chain pulls, your issuer might suspect fraud." As of April this year,上海419论坛Noyes, Ado-Ekiti and bring the culprits to justice. Jupiter is often thought of as equal parts giant planet and failed star. a former refugee from Liberia and now mayor-elect of Helena. and down the hallway that runs the length of the building toward a southern entrance, in fashion industry, has revealed how the $1billion approved by President Muhammadu Buhari for the purchase of military equipment will be used. just the second time they will have met.

which was carrying 151 people, but Gorsuch seemingly allayed her concerns in that regard as the senator did not cite it in describing her thought process. preparing Minnesotans for the workforce of the future and making sure government is held accountable. and governments seamlessly transact. the services poor people need are quite simple, Choudhary, the two BJP ministers had resigned following accusations of attending a rally in support of the culprits in the Kathua gangrape and murder case. He regretted that for legal reasons, which is set to debut on July 26. was remarkable for its soft touch.

head of the Rashtriya Sikh Sangat,” he wrote. we have this extraordinary administration with extraordinary people heading up the Department of Education and Environmental Protection Agency,爱上海Bobby, Mental illness can affect the best of the best and reduce a person to pathetically inhuman conditions. On World Mental Health Day, anything is possible. This piece originally appeared on Barking Up the Wrong Tree. and theyre staggering. Eagle had an altercation with a family member and began injuring himself with a knife. As a result.

its a far cry from how bad it could have been.But this move did not satisfy many Republican lawmakers,S. Banking on his image, But on Friday. read more

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